Clindamycin phosphate vaginal gel detection method and device

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By designing an automated clindamycin phosphate vaginal gel detection device, the problem of traditional inefficiency is solved, automatic preparation and efficient detection are realized, and the quality and safety of the drug are ensured.

CN119574896APending Publication Date: 2025-03-07DUODUO PHARMA

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Patent Information

Application Number: CN202411751642.5
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2024-12-02
Publication Date: 2025-03-07

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Abstract

The invention discloses a clindamycin phosphate vaginal gel detection method and device, and relates to the technical field of vaginal gel detection. The detection method comprises the following steps: step 1, respectively putting a monopotassium phosphate solution and acetonitrile into two raw material supply tanks, putting clindamycin phosphate vaginal gel to be detected into a preparation tank, and leading the two raw material supply tanks to the preparation tank for adding raw materials; step 2, placing a plurality of preparation tanks on a bottle-changing rotating disc, rotating the bottle-changing rotating disc when the adding amount of the preparation tanks in which the clindamycin phosphate vaginal gel to be detected is added meets the requirement, adjusting the positions of the preparation tanks, and transferring the clindamycin phosphate vaginal gel to the bottle-changing rotating disc; rotating a bottle-changing rotating disc and pushing a tank-making device containing clindamycin phosphate vaginal gel to be detected onto a telescopic assembly; raw materials can be automatically configured, configuration can be completed in the process of moving the preparation tank, the configuration efficiency is improved, the preparation tank is limited through the supporting frame and the synchronous pushing assembly together after carrying, and the preparation tank is fixed, so that the subsequent liquid taking process is facilitated.

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Description

Technical Field

[0001] The present invention relates to the technical field of vaginal gel detection, and more particularly to a clindamycin phosphate vaginal gel detection device and a detection method thereof. Background Art

[0002] Clindamycin phosphate vaginal gel is a gynecological drug used to treat various infectious diseases caused by sensitive bacteria, especially for female pelvic and genital infections, such as bacterial vaginosis and trichomoniasis. In order to ensure the quality of clindamycin phosphate vaginal gel, it is necessary to detect the content of clindamycin impurities therein. Less clindamycin impurities can effectively improve the drug quality of clindamycin phosphate vaginal gel, and the impurities contained therein may have adverse effects on the human body and even cause adverse reactions. By detecting and controlling the content of clindamycin impurities, the safety of drugs can be ensured. In the traditional detection process, it relies on professionals to manually configure the detection, which wastes manpower and is inefficient. Therefore, it is necessary to design a clindamycin phosphate vaginal gel detection device and a detection method thereof. Summary of the invention

[0003] The purpose of the present invention is to provide a method and a device for detecting clindamycin phosphate vaginal gel, which have the advantage of being able to automatically configure the clindamycin phosphate vaginal gel to be detected.

[0004] The purpose of the present invention is achieved through the following technical solutions:

[0005] The clindamycin phosphate vaginal gel detection device comprises a raw material supply tank; a supply pipeline arranged on the raw material supply tank; a supply pump located on the supply pipeline; a pipeline pick-up and delivery wheel clamping the supply pipeline; a lifting gear driven by the pipeline pick-up and delivery wheel; a lifting control screw rod fixedly connected to the lifting gear; a preparation component driven by the lifting control screw rod through a thread; a support frame for supporting the configuration component; a synchronous pushing component arranged on the support frame and meshing with the pipeline pick-up and delivery wheel for transmission; a telescopic component arranged on the support frame; a synchronous loading tray arranged on the support frame; and a preparation tank for placing clindamycin phosphate vaginal gel, a plurality of preparation tanks are arranged on the synchronous loading tray, and the plurality of preparation tanks are slidably connected to the support frame.

[0006] Furthermore, the supply pipeline includes a fixed section, a relaxation section and an elastic bending feeding section. A supply pump is connected between the fixed section and the relaxation section. The elastic bending feeding section is arranged at the end of the relaxation section. As the elastic bending feeding section moves with the pipeline picking and feeding wheel, the end of the elastic bending feeding section gradually turns from horizontal to downward.

[0007] Furthermore, the pipe picking and feeding wheel includes a transmission gear; a rotating shaft fixedly connected to the transmission gear; a support block fixedly connected to the support frame for supporting the rotating shaft; a driven gear arranged at the other end of the supporting rotating shaft; and a plurality of clamping rods arranged on the transmission gear and the driven gear, and the plurality of clamping rods are used to limit the sliding of the elastic bending feeding section.

[0008] Furthermore, the supporting configuration component includes an integral support frame; two lifting plates arranged on the integral support frame; a lifting screw rod that is threadedly driven with the integral support frame; a driving gear arranged on the lifting screw rod, the driving gear meshing with the transmission gear for transmission; and a driving bevel gear arranged at the bottom of the lifting screw rod.

[0009] Furthermore, the support frame includes a detection frame for supporting the overall support frame, and the lifting screw is rotatably connected to the detection frame; and a detection tray support frame for supporting a synchronous loading tray and arranged on the detection frame; and an upper configuration bracket arranged on the detection frame; and two limiting grooves arranged on the upper configuration bracket, and both limiting grooves are arranged in an arc shape.

[0010] Furthermore, the synchronous pushing assembly includes a transmission pushing gear; and a can pushing assembly that rotates synchronously with the transmission pushing gear; and a synchronous transmission gear that meshes with the transmission pushing gear for transmission; and a synchronous gear fixedly connected to the synchronous transmission gear, two synchronous gears are provided, and the two synchronous gears are synchronously driven by a toothed belt; and a first transmission gear fixedly connected to another synchronous gear, the first transmission gear meshes with the driven gear for transmission, the can pushing assembly, the synchronous transmission gear and the synchronous gear are all arranged on the detection frame; and a can pushing frame that is threadedly driven with the can pushing assembly and is slidably connected to the detection frame; and two can plates arranged on the can pushing frame.

[0011] Furthermore, both of the two tank presentation plates are provided with tank presentation grooves, and the diameter of the tank presentation grooves is smaller than that of the preparation tank. According to the clindamycin phosphate vaginal gel detection device described in the claim, the telescopic assembly comprises a fixed tube arranged on the detection frame; a lifting column arranged on the fixed tube; a connecting spring sleeved on the lifting column; a bearing tray arranged on the upper end of the lifting column, and the diameter of the tank presentation groove is larger than that of the bearing tray; a telescopic rod arranged on the bearing tray; a reset spring sleeved on the telescopic rod; and a pressure plate arranged on the telescopic rod, and a pressure sensor is arranged between the pressure plate and the telescopic rod.

[0012] Furthermore, the synchronous loading tray includes a bottle changing rotating tray rotatably connected to the detection tray support frame; and a connecting shaft arranged on the bottle changing rotating tray, the connecting shaft being rotatably connected to the detection frame; and a transmission bevel gear arranged on the connecting shaft; and a bevel gear gear shaft meshing with the transmission bevel gear for transmission; and a toothless bevel gear arranged on the bevel gear gear shaft.

[0013] Further, a method for detecting clindamycin phosphate vaginal gel is provided, the method comprising the following steps:

[0014] Step 1: Potassium dihydrogen phosphate solution and acetonitrile are placed in two raw material supply tanks respectively, and the clindamycin phosphate vaginal gel to be tested is placed in a preparation tank, and both raw material supply tanks are connected to the preparation tank for adding raw materials;

[0015] Step 2: multiple preparation cans are placed on the bottle changing rotating disk, and when the amount of the clindamycin phosphate vaginal gel to be tested added to the preparation can reaches the requirement, the bottle changing rotating disk is rotated to adjust the position of the preparation can, and the bottle changing rotating disk is rotated to push the preparation can containing the clindamycin phosphate vaginal gel to be tested onto the telescopic component;

[0016] Step 3: The telescopic component is lifted along with the preparation component. After being lifted to the designated position, the synchronous pushing component moves the preparation tank to the support frame. During the process, potassium dihydrogen phosphate solution and acetonitrile are respectively added to the preparation tank from the raw material supply tank, so that the potassium dihydrogen phosphate solution and acetonitrile are configured in a ratio of 31:9 to form a mobile phase;

[0017] Step 4: Then, one of the preparation tanks equipped with the mobile phase was made into a mobile phase containing half the amount of clindamycin phosphate vaginal gel as the other one, which was used as the control group. Then, equal amounts of solution from the two preparation tanks were taken out for measurement.

[0018] The beneficial effects of the clindamycin phosphate vaginal gel detection device and the detection method of the present invention are:

[0019] 1. It can automatically prepare solutions for testing, replacing manual labor with machinery to increase efficiency.

[0020] 2. By placing potassium dihydrogen phosphate solution and acetonitrile in two raw material supply tanks 11 respectively, the extraction rate ratio of potassium dihydrogen phosphate solution and acetonitrile is set to be fixed, and the rate ratio is 31:9, which can ensure the quality of clindamycin phosphate vaginal gel tested as needed during the configuration process. The time for adding potassium dihydrogen phosphate solution and acetonitrile only needs to be increased and reduced at the same time, which can effectively ensure that the ratio of the mixed solution is 31:9, reduce errors, and through this solution ratio, the clindamycin phosphate vaginal gel can be more fully dispersed.

[0021] 3. The synchronous pushing component moves synchronously, and the preparation tank moves with the telescopic component until the synchronous pushing component contacts the telescopic component. When in contact, the synchronous pushing component pushes the preparation tank to slide onto the support frame to complete the movement of the preparation tank. Automatic configuration during the movement process improves configuration efficiency.

[0022] 4. The preparation tank is pushed from the synchronous loading tray to the telescopic component, and then transported to the support frame for fixing. The whole process is closely connected, which reduces the configuration time. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The present invention is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0024] Figure 1 It is an overall diagram of the present invention;

[0025] Figure 2 It is another perspective of the overall diagram of the present invention;

[0026] Figure 3 It is a schematic diagram of the connection between the pipeline taking and delivering wheel, the preparation component and the synchronous pushing component of the present invention;

[0027] Figure 4 It is a schematic diagram of the connection of the pipeline taking and delivering wheel, the preparation component, the synchronous pushing component and the telescopic component of the present invention;

[0028] Figure 5 It is the integral support frame of the present invention;

[0029] Figure 6 is a support frame of the present invention;

[0030] Figure 7 It is a schematic diagram of the connection between the raw material supply tank, the supply pump, the raw material supply pipeline, the pipeline pick-up and delivery wheel, the lifting gear, the lifting control screw rod and the synchronous pushing assembly of the present invention;

[0031] Figure 8 is a cross-sectional view of a telescopic assembly of the present invention;

[0032] Fig. 9 The present invention Figure 8 Partial magnification;

[0033] Fig.10 It is the synchronous loading tray of the present invention;

[0034] Fig.11 It is a flow chart of the present invention.

[0035] In the figure: raw material supply tank 11; supply pump 124; raw supply pipeline 12; pipeline pick-up wheel 13; lifting gear 14; lifting control screw 15; preparation component 2; support frame 3; synchronous push component 4; telescopic component 5; synchronous loading tray 6; fixed section 121; release section 122; elastic bending feeding section 123; transmission gear 131; rotating shaft 132; support block 133; driven gear 134; clamping rod 135; overall support frame 21; lifting plate 22; driving bevel gear 16; Detection frame 31; detection plate support frame 32; upper configuration bracket 33; limiting groove 34; transmission push gear 41; can push assembly 42; synchronous transmission gear 43; synchronous gear 44; first transmission gear 45; can push frame 46; can plate 47; fixed tube 51; lifting column 52; connecting spring 53; bearing tray 54; telescopic rod 55; reset spring 56; pressure plate 57; bottle changing rotating disk 62; connecting shaft 63; transmission bevel gear 64; bevel gear gear shaft 67; toothless bevel gear 68. DETAILED DESCRIPTION

[0036] The present invention will be further described in detail below in conjunction with the accompanying drawings.

[0037] Specific embodiment 1: According to Figure 1 and Fig.10 The following is an example of the raw material configuration process:

[0038] The clindamycin phosphate vaginal gel detection device comprises a raw material supply tank 11 and a supply pipeline 12; the supply pipeline 12 is detachably connected to the raw material supply tank 11, and a supply pump 124 is fixedly connected to the supply pipeline 12; and a pipeline pick-up and delivery wheel 13 clamping the supply pipeline 12; and a lifting gear 14 driven by the pipeline pick-up and delivery wheel 13; and a lifting control screw rod 15 fixedly connected to the lifting gear 14; and a preparation component 2 driven by the lifting control screw rod 15 through a thread; and a support frame 3 for supporting the preparation component 2; and a synchronous pushing component 4 arranged on the support frame 3 and meshing with the pipeline pick-up and delivery wheel 13 for transmission; and a preparation component 2 arranged on the support frame 3 The telescopic assembly 5; and a synchronous loading tray 6 arranged on the support frame 3; and a preparation tank 28 for placing clindamycin phosphate vaginal gel, a plurality of preparation tanks 28 are arranged on the synchronous loading tray 6, and a plurality of preparation tanks 28 are slidably connected to the support frame 3. When in use, potassium dihydrogen phosphate solution and acetonitrile are placed in two raw material supply tanks 11 respectively, and the extraction rate ratio of potassium dihydrogen phosphate solution and acetonitrile is set to be fixed, and the rate ratio is 31:9, which can ensure the quality of clindamycin phosphate vaginal gel detected as needed during the configuration process, and the time for adding potassium dihydrogen phosphate solution and acetonitrile only needs to be increased and reduced at the same time, which can effectively ensure the configuration. The mixed solution is 31:9. This solution ratio can make the clindamycin phosphate vaginal gel more fully dispersed, and can ensure that the added solution can produce a pH value of 2.5 after the ratio is adjusted, which is convenient for subsequent liquid chromatograph measurement. The raw materials are supplied through the material supply tank 11, and the supply pump 124 provides the power for adding the raw materials. The raw materials placed in the material supply tank 11 can be extracted by starting the supply pump 124. Before adding, a plurality of preparation tanks 28 are placed on the synchronous feeding tray 6, and the clindamycin phosphate vaginal gel to be tested is placed therein. As the synchronous feeding tray 6 rotates, the synchronous feeding tray 6 rotates during the rotation process. The two preparation tanks 28 are moved to the designated position and then onto the telescopic component 5. After the movement, the telescopic component 5 is lifted by the preparation component 2. As the lifting proceeds, the synchronous pushing component 4 moves synchronously, and the telescopic component 5 carries the preparation tank 28 to move until the synchronous pushing component 4 contacts the telescopic component 5. When in contact, the synchronous pushing component 4 pushes the preparation tank 28 to slide onto the support frame 3 to complete the movement of the preparation tank 28. The ability to complete the configuration in the process of moving the preparation tank 28 improves the configuration efficiency. After transportation, the support frame 3 and the synchronous pushing component 4 jointly restrict the preparation tank 28 to complete the fixation of the preparation tank 28 for the subsequent liquid extraction process.

[0039] Specific embodiment 2: According to Figure 1 and Fig.10 The following is an example of the raw material supply process:

[0040] The pipe picking and delivering wheel 13 limits the position of the supply pipe 12. As the preparation component 2 lifts the telescopic component 5, the pipe picking and delivering wheel 13 rotates accordingly. During the rotation, the direction of the end of the supply pipe 12 is adjusted and rotated to the mouth of the preparation tank 28, thereby producing the effect of raw material supply.

[0041] Specific embodiment three: According to Figure 1 and Fig.10 As shown, it is an example of adjusting the direction of the supply pipeline as the preparation tank 28 moves:

[0042] The supply pipeline 12 includes a fixed section 121, a relaxation section 122 and an elastic bending feeding section 123. The relaxation section 122 is relatively long and is arranged in a spiral tube. In the initial state, it is in a relaxed state. In the initial state, the elastic bending feeding section 123 is facing horizontally. The distance between the upper end surface of the telescopic component 5 and the lower end surface of the synchronous pushing component 4 is the height of the preparation tank 28. A supply pump 124 is connected between the fixed section 121 and the relaxation section 122. The elastic bending feeding section 123 is arranged at the end of the relaxation section 122. As the elastic bending feeding section 123 moves with the pipeline picking and feeding wheel 13, the end direction of the elastic bending feeding section 123 gradually turns from horizontal to downward.

[0043] Specific embodiment 4: According to Figure 1 and Fig.10 As shown, it is an example of the transmission adjustment of the pipeline pick-up and delivery wheel 13 and the elastic bending and feeding section 123:

[0044] The pipeline picking and feeding wheel 13 includes a transmission gear 131; and a rotating shaft 132 fixedly connected to the transmission gear 131; and a detection disk support frame 32 arranged on the detection frame 31, the detection disk support frame 32 is used to support the synchronous loading disk 6; and a driven gear 134 arranged at the other end of the supporting rotating shaft 132; and a plurality of clamping rods 135 arranged on the transmission gear 131 and the driven gear 134, and the plurality of clamping rods 135 are used to limit the sliding of the elastic bending feeding section 123. The rotation of the transmission gear 131 can drive the rotating shaft 132 and the driven gear 134 to rotate, and then drive the plurality of clamping rods 135 to rotate. Under the restriction of the plurality of clamping rods 135, the elastic bending feeding section 123 can be effectively driven to adjust its direction, so that the opening of the elastic bending feeding section 123 can be directed to the tank mouth of the preparation tank 28 and the elastic bending feeding section 123 can enter the preparation tank 28, and then the supply pump 124 is started, and the automatic loading is effective.

[0045] Specific embodiment 5: According to Figure 1 and Fig.10 As shown, it is an example of synchronous lifting telescopic component 5:

[0046] The support configuration component 2 includes an integral support frame 21; two connecting slides 23 fixedly connected to the integral support frame 21; and a lifting plate 22 slidably connected to the two connecting slides 23, respectively. A spring is arranged between the two lifting plates 22 and the support frame 21. When the lifting plate 22 lifts the two telescopic components 5, as the telescopic components 5 move, the telescopic components 5 contact the synchronous pushing component 4, so that the spring arranged between the two lifting plates 22 and the support frame 21 can be compressed, and the telescopic components 5 are kept stationary at this position, and the lifting gear 14 and the transmission gear 13 are moved. 1 meshing transmission; and the driving bevel gear 16 fixed to the bottom of the lifting control screw 15, when the transmission gear 131 rotates to adjust the opening direction of the elastic bending feeding section 123, the meshing lifting gear 14 will rotate, driving the lifting control screw 15 to rotate, and under the limiting action of the two telescopic components 5, the thread pushes the overall support frame 21 to move, thereby generating an effect of rising or falling, thereby achieving the effect of driving the telescopic component 5 and the preparation tank 28 thereon to move, and achieving the effect of adjusting the opening direction of the elastic bending feeding section 123 and moving the preparation tank 28 at the same time.

[0047] Specific embodiment six: according to Figure 1 and Fig.10 As shown, it is an example of the support frame 3 playing a role in overall support and positioning restriction of the preparation tank 28 after movement:

[0048] The support frame 3 includes a detection frame 31 for supporting the overall support frame 21, and a detection tray support frame 32 for supporting the synchronous loading tray 6 and arranged on the detection frame 31; and an upper configuration bracket 33 arranged on the detection frame 31; and two limiting grooves 34 arranged on the upper configuration bracket 33, and the two limiting grooves 34 are both arranged in an arc shape. Through the arc-shaped limiting grooves 34, the preparation tank 28 can be moved to fit therewith, and then cooperate with the synchronous pushing component 4 to limit the preparation tank 28 and fix the preparation tank 28 so that the solution can be extracted for testing later. The remaining components can be supported by the detection frame 31 and the detection tray support frame 32.

[0049] Specific embodiment seven: according to Figure 1 and Fig.10 As shown, it is an example of synchronously adjusting the direction of the elastic bending feeding section 123 and synchronously pushing the component 4 to push the preparation tank 28:

[0050] The synchronous pushing assembly 4 includes a transmission pushing gear 41; and a can pushing assembly 42 that rotates synchronously with the transmission pushing gear 41, the can pushing assembly 42 is composed of a screw, a motor and a limit rod, the motor is fixed to the detection frame 31, the screw is fixed to the motor output shaft, the limit rod is set on the detection frame 31, the can pushing frame 46 is slidably connected to the limit rod, and a synchronous transmission gear 43 that meshes with the transmission pushing gear 41 for transmission; and a synchronous gear 44 fixed to the synchronous transmission gear 43, two synchronous gears 44 are provided, and the two synchronous gears 44 are synchronously driven by a toothed belt 48; and a first transmission gear 45 fixed to another synchronous gear 44, the first transmission gear 45 is meshed with the driven gear 134 for transmission, the can pushing assembly 42 is fixed to the detection frame 31, and the synchronous transmission gear 43 and the synchronous gear 44 both rotate on the detection frame 31; The can push rack 46 is threadedly driven by the can push assembly 42, and the can push rack 46 is slidably connected to the detection rack 31; and the two can plates 47 fixed to the can push rack 46, when the transmission gear 131 rotates, synchronously drives the driven gear 134 to rotate, so that the first transmission gear 45 meshing therewith rotates synchronously with the synchronous gear 44, and the synchronous transmission gear 43 rotates under the action of the toothed belt transmission, and then the transmission push gear 41 rotates, and the screw rod of the can push assembly 42 rotates, and the can push rack 46 moves under the thread push of the can push assembly 42. During the movement, the preparation tank 28 is carried away from the telescopic assembly 5, and the preparation tank 28 is driven to move to the limited groove 34, completing the effect of synchronously adjusting the direction of the elastic bending feeding section 123 and the synchronous pushing assembly 4 pushing the preparation tank 28 to the specified position for fixing, and completing the automatic movement of the preparation tank 28 to the detection position.

[0051] Specific embodiment eight: according to Figure 1 and Fig.10 As shown, it is an example of how to receive the preparation tank 28:

[0052] The two tank presenting plates 47 are both provided with tank presenting grooves, the diameter of which is smaller than that of the preparation tank 28, and also include a receiving tray 54 arranged at the upper end of the lifting column 52, the diameter of which is larger than the diameter of the receiving tray 54, so that when the preparation tank 28 is transferred, it can be moved away from the tank presenting plate 47 to realize the transfer of the preparation tank 28.

[0053] Specific embodiment nine: According to Figures 1 to 10 As shown, it is an example of the telescopic assembly 5 receiving and lifting the preparation tank 28:

[0054] The telescopic assembly 5 includes a fixed tube 51 arranged on the detection frame 31; and a lifting column 52 arranged on the fixed tube 51, the fixed tube 51 is slidably connected to the lifting plate 22; and a connecting spring 53 sleeved on the lifting column 52; and a telescopic rod 55 arranged on the bearing tray 54; and a return spring 56 sleeved on the telescopic rod 55; and a pressure plate 57 arranged on the telescopic rod 55, and a pressure sensor is arranged between the pressure plate 57 and the telescopic rod 55. When the lifting plate 22 is lifted as the overall support frame 21 is lifted, the lifting column 52 slides out of the fixed tube 51. The fixed pipe 51 and the connecting spring 53 are stretched, so that the preparation tank 28 can be lifted. Then, materials are added during the process of lifting. Then, the preparation tank 28 rises again, and the elastically bent feeding section 123 slides out of the preparation tank 28. As the lifting continues, it contacts the synchronously moving can pusher 46. The can pusher 46 limits the continued lifting of the support tray 54 and pushes the preparation tank 28 away. Then, the lifting plate 22 stops rising, and the lifting process of the preparation tank 28 is completed. After the lifting, during the process of returning to the original position, the lifting column 52 returns to the original position under the elastic force of the connecting spring 53.

[0055] When the lifting work starts, the synchronous loading tray 6 rotates to move the preparation tank 28 onto the supporting tray 54, and presses down the pressure plate 57 on the supporting tray 54, so that the pressure sensor senses the pressure and converts it into an electrical signal. Then, the motor of the pushing tank assembly 42 is controlled to start the motor to complete the lifting work. Then, the contact time refers to the time when the preparation tank 28 is pushed until the solution is absorbed, and the motor reverses to complete the return to original position work.

[0056] Specific embodiment ten: According to Figures 1 to 10 As shown, it is an example of synchronously moving the feeding tray 6 and the preparation tank 28:

[0057] The synchronous loading disc 6 comprises a bottle changing rotating disc 62 rotatably connected to the detection disc support frame 32; and a connecting shaft 63 arranged on the bottle changing rotating disc 62, the connecting shaft 63 is rotatably connected to the detection frame 31; and a transmission bevel gear 64 arranged on the connecting shaft 63; and a bevel gear gear shaft 67 meshing with the transmission bevel gear 64 for transmission, the bevel gear gear shaft 67 is composed of a shaft and a bevel gear, and the bevel gear is meshing with the driving bevel gear 16 for transmission; and a toothless bevel gear 68 arranged on the bevel gear gear shaft 67, when the lifting control screw 15 rotates, the driving bevel gear 16 is driven to rotate, and then the bevel gear gear shaft 67 is driven to rotate, and the transmission bevel gear 64 is intermittently driven by the toothless bevel gear 68 to rotate, thereby realizing that after the preparation tank 28 is lifted until it returns to its original position, the preparation tank 28 containing the new clindamycin phosphate vaginal gel to be tested is rotated to be aligned with the telescopic rod 55.

[0058] Specific embodiment eleven: According to Figure 1 and Fig.11The figure shows an example of the clindamycin phosphate vaginal gel detection method of the device.

[0059] The clindamycin phosphate vaginal gel detection device also relates to a clindamycin phosphate vaginal gel detection method, which comprises the following steps:

[0060] Step 1: Potassium dihydrogen phosphate solution and acetonitrile are placed in two raw material supply tanks 11 respectively, and the clindamycin phosphate vaginal gel to be tested is placed in a preparation tank 28, and both raw material supply tanks 11 are connected to the preparation tank 28 for adding raw materials;

[0061] Step 2: multiple preparation tanks 28 are placed on the bottle changing rotating disk 62. When the amount of the clindamycin phosphate vaginal gel to be tested in the preparation tank 28 reaches the requirement, the bottle changing rotating disk 61 rotates to adjust the position of the preparation tank 28, and the bottle changing rotating disk 62 rotates to push the preparation tank 28 containing the clindamycin phosphate vaginal gel to be tested onto the telescopic component 5;

[0062] Step 3: The telescopic component 5 is lifted along with the preparation component 2. After being lifted to the designated position, the synchronous pushing component 4 moves the preparation tank 28 to the support frame 3. During the process, potassium dihydrogen phosphate solution and acetonitrile are respectively added to the preparation tank 28 from the raw material supply tank 11, so that the potassium dihydrogen phosphate solution and acetonitrile are configured in a ratio of 31:9 to form a mobile phase;

[0063] Step 4: After that, a preparation tank 28 is installed to form a mobile phase, and one of them is made into a mobile phase containing half the amount of the other one of the clindamycin phosphate vaginal gel, which is the control group. Then, equal amounts of solutions from the two preparation tanks 28 are taken out for measurement. During the measurement, octyl oxadiazine bonded silica gel is used as a filler to adsorb the added solution. 10 μl of the control solution is injected into the liquid chromatograph, and the detection sensitivity is adjusted so that the peak height of the main component peak is about 40-50% of the full scale of the recorder; then 10 μl of the test solution and the reference solution are measured and injected into the liquid chromatograph, and the chromatogram is recorded to 2.5 times the retention time of the main component peak of the test solution. If there is a clindamycin peak in the chromatogram of the test solution, the area of this peak shall not be greater than 5.0% of the main component peak area of the control solution.

[0064] Of course, the above description is not a limitation of the present invention, and the present invention is not limited to the above examples. Changes, modifications, additions or substitutions made by ordinary technicians in this technical field within the essential scope of the present invention also fall within the protection scope of the present invention.

Claims

1. Clindamycin phosphate vaginal gel detection device, characterized in that: The invention comprises a raw material supply tank (11); a supply pipeline (12) arranged on the raw material supply tank (11); a supply pump (124) located on the supply pipeline (12); a pipeline pick-up wheel (13) clamping the supply pipeline (12); a lifting gear (14) driving the pipeline pick-up wheel (13); a lifting control screw rod (15) fixedly connected to the lifting gear (14); and a driving bevel gear (16) arranged on the lifting control screw rod (15); and A preparation component (2) driven by a lifting control screw rod (15) through a threaded drive; a support frame (3) for supporting the preparation component (2); a synchronous pushing component (4) arranged on the support frame (3) and meshing with a pipeline taking and delivering wheel (13); a telescopic component (5) arranged on the support frame (3); a synchronous loading tray (6) arranged on the support frame (3); and a preparation tank (28) for placing clindamycin phosphate vaginal gel, wherein a plurality of preparation tanks (28) are arranged on the synchronous loading tray (6), and the plurality of preparation tanks (28) are slidably connected to the support frame (3).

2. The clindamycin phosphate vaginal gel detection device according to claim 1, characterized in that: The supply pipeline (12) comprises a fixed section (121), a relaxing section (122) and an elastically bent feeding section (123); a supply pump (124) is connected between the fixed section (121) and the relaxing section (122); the elastically bent feeding section (123) is arranged at the end of the relaxing section (122); and the end of the elastically bent feeding section (123) gradually turns from horizontal to downward as the pipeline picking-up and feeding wheel (13) moves.

3. The clindamycin phosphate vaginal gel detection device according to claim 1, characterized in that: The pipe picking-up and feeding wheel (13) comprises a transmission gear (131); a rotating shaft (132) fixedly connected to the transmission gear (131); a support block (133) fixedly connected to the support frame (3) for supporting the rotating shaft (132); a driven gear (134) arranged at the other end of the supporting rotating shaft (132); and a plurality of clamping rods (135) arranged on the transmission gear (131) and the driven gear (134), wherein the plurality of clamping rods (135) are used to limit the sliding of the elastically bent feeding section (123).

4. The clindamycin phosphate vaginal gel detection device according to claim 3, characterized in that: The support configuration component (2) comprises an integral support frame (21); two connecting slides (23) arranged on the integral support frame (21); and a lifting plate (22) respectively slidably connected to the two connecting slides (23).

5. The clindamycin phosphate vaginal gel detection device according to claim 4, characterized in that: The support frame (3) comprises a detection frame (31) for supporting the overall support frame (21), and a detection plate support frame (32) arranged on the detection frame (31), the detection plate support frame (32) being used to support a synchronous loading plate (6); and an upper configuration support (33) arranged on the detection frame (31); and two limiting grooves (34) arranged on the upper configuration support (33), the two limiting grooves (34) being both arranged in an arc shape.

6. The clindamycin phosphate vaginal gel detection device according to claim 5, characterized in that: The synchronous pushing assembly (4) comprises a transmission pushing gear (41); a can pushing assembly (42) rotating synchronously with the transmission pushing gear (41); a synchronous transmission gear (43) meshing with the transmission pushing gear (41); a synchronous gear (44) fixedly connected to the synchronous transmission gear (43), wherein two synchronous gears (44) are provided, and the two synchronous gears (44) are synchronously driven by a toothed belt (48); a first transmission gear (45) fixedly connected to another synchronous gear (44), and the first transmission gear (45) meshes with a driven gear (134) for transmission, and the can pushing assembly (42), the synchronous transmission gear (43) and the synchronous gear (44) are all arranged on the detection frame (31); a can pushing frame (46) threadedly driven with the can pushing assembly (42) and slidably connected to the detection frame (31); and two can plates (47) arranged on the can pushing frame (46).

7. The clindamycin phosphate vaginal gel detection device according to claim 6, characterized in that: The two tank presentation plates (47) are both provided with tank presentation grooves, and the diameter of the tank presentation grooves is smaller than that of the preparation tank (28).

8. The clindamycin phosphate vaginal gel detection device according to claim 6, characterized in that: The telescopic assembly (5) comprises a fixed tube (51) arranged on the detection frame (31); a lifting column (52) arranged on the fixed tube (51); a connecting spring (53) sleeved on the lifting column (52); a bearing tray (54) arranged on the upper end of the lifting column (52), the tank diameter of which is larger than the diameter of the bearing tray (54); a telescopic rod (55) arranged on the bearing tray (54); a reset spring (56) sleeved on the telescopic rod (55); and a pressure plate (57) arranged on the telescopic rod (55), wherein a pressure sensor is arranged between the pressure plate (57) and the telescopic rod (55).

9. The clindamycin phosphate vaginal gel detection device according to claim 8, characterized in that: The synchronous loading plate (6) comprises a bottle changing rotating plate (62) rotatably connected to the detection plate support frame (32); and a connecting shaft (63) arranged on the bottle changing rotating disk (62), the connecting shaft (63) being rotatably connected to the detection frame (31); and a transmission bevel gear (64) arranged on the connecting shaft (63); and a bevel gear shaft (67) meshing with the transmission bevel gear (64) for transmission, the bevel gear shaft (67) meshing with the driving bevel gear (16) for transmission; and a toothless bevel gear (68) arranged on the bevel gear shaft (67).

10. A method for detecting clindamycin phosphate vaginal gel, characterized in that: The method comprises the following steps: Step 1: Potassium dihydrogen phosphate solution and acetonitrile are placed in two raw material supply tanks (11) respectively, and the clindamycin phosphate vaginal gel to be tested is placed in a preparation tank 28. Both raw material supply tanks (11) lead to the preparation tank (28) for adding raw materials; Step 2: a plurality of preparation tanks (28) are placed on the bottle changing rotating disk (62); when the amount of the clindamycin phosphate vaginal gel to be tested added to the preparation tank (28) reaches the required amount, the bottle changing rotating disk (61) is rotated to adjust the position of the preparation tank (28); the bottle changing rotating disk (62) is rotated to push the preparation tank (28) containing the clindamycin phosphate vaginal gel to be tested onto the telescopic component (5); Step 3: The telescopic component (5) is lifted along with the preparation component (2). After being lifted to the designated position, the synchronous pushing component (4) moves the preparation tank (28) to the support frame (3). During the process, potassium dihydrogen phosphate solution and acetonitrile are respectively supplied from the raw material supply tank (11) to the preparation tank (28), so that the potassium dihydrogen phosphate solution and acetonitrile are configured to form a mobile phase in a ratio of 31:9; Step 4: Then, a preparation tank (28) is installed to form a mobile phase, one of which is made into a mobile phase containing half the amount of clindamycin phosphate vaginal gel as the other one, which is a control group. Then, equal amounts of solutions from the two preparation tanks (28) are taken out for measurement.