Gynecological gel as well as preparation method and application thereof

Abstract

The invention discloses gynecological gel as well as a preparation method and application thereof, and belongs to the technical field of gynecological gels, carbomer of a high-molecular polymer is mainly used as a main gel matrix, and on the basis that carbomer is used as the main gel matrix, a humectant glycerol, a stabilizer and a film-forming agent sodium alginate are matched, so that the gynecological gel is prepared. Gel is prepared from a semi-finished product of gel, a lubricant polyethylene glycol 4000 and a pH regulator triethanolamine, ethylparaben and purified water are added into the semi-finished product of gel, the gel further comprises a botanical medicine extract capable of inducing diuresis and resisting viruses for gynecology, and an antibacterial agent for treating Escherichia coli, Candida albicans, Candida albicans and Candida albicans is added into the semi-finished product of gel. The invention relates to an antibacterial Chinese patent medicine extract for inhibiting staphylococcus aureus. A layer of protective gel film is formed on the vaginal wall to physically isolate the vaginal wall from external bacteria, so that pathogenic microorganisms are prevented from colonization, and the vaginal gel conforms to the market development trend and the medication concept of modern people and has profound significance.

Description

Technical Field

[0001] The invention belongs to the technical field of gynecological gel, and specifically relates to a gynecological gel and a preparation method and application thereof. Background Art

[0002] Explanation of domestic and foreign market conditions: Gynecological inflammation and cervical erosion are common and frequently occurring gynecological diseases, belonging to the category of "leucorrhea" in traditional Chinese medicine, and the incidence rate accounts for about 60% of gynecological outpatient visits. From the perspective of the three major markets of Beijing, Shanghai and Guangdong, Beijing is the largest market for gynecological anti-infection gel, followed by Shanghai and Guangdong. Gynecological inflammation drugs have grown rapidly in recent years, and the market structure of gynecological inflammation drugs has also changed. High recurrence rate is the main feature of gynecological diseases, which also reflects the huge market for gynecological inflammation treatment drugs.

[0003] With the progress of society, people's health awareness is receiving more and more attention, especially green and physical treatment methods are one of the important means for people to pursue health. Summary of the invention

[0004] The purpose of the present invention is to provide a gynecological gel and a preparation method and application thereof, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions: This embodiment provides a gynecological gel, comprising carbomer, a high molecular polymer, as a main gel matrix, and a moisturizing agent glycerin, a stabilizer and a film-forming agent sodium alginate, a lubricant polyethylene glycol 4000, and a pH regulator triethanolamine are added to the gel semi-finished product to prepare a gel; ethyl hydroxybenzoate and purified water are added to the semi-finished gel;

[0006] The gel also includes a plant-derived medicinal extract that can have gynecological diuretic and antiviral effects;

[0007] The antibacterial Chinese patent medicine extract for inhibiting Escherichia coli, Candida albicans and Staphylococcus aureus is added to the semi-finished gel product.

[0008] Preferably, the ingredients and their mass ratios are as follows: 30-45% carbomer, 15-20% glycerol, 10-15% sodium alginate, 10-13% ethylene glycol 4000, 10-13% triethanolamine, 8-12% ethylparaben, and 15-25% purified water.

[0009] Preferably, the plant-derived drug extract includes: 5-12% matrine, 4-10% cnidium monnieri, 4-12% phellodendron, 4-7% angelica, 1-3% safflower, 2-4% alum, 2-4% chlorhexidine, and 1-4% borneol.

[0010] Preferably, the antibacterial Chinese patent medicine extract comprises: catechu 1-3%, safflower 0.5-1%, dandelion 1-1.5%, houttuynia cordata 1-2%, patrinia 1-3%, and red peony root 0.7-1.4%.

[0011] A method for preparing a gynecological gel comprises the following steps:

[0012] S1: Weighing: weigh carbomer, glycerin, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts for each formula raw material, and place them aside after weighing according to the ratio;

[0013] S2: dissolving and stirring, dissolving the sodium alginate and polyethylene glycol 4000 prepared in S1 and stirring for 1.5 h to 3 h;

[0014] S3: dissolution, carbomer dissolution time: 10h~12h;

[0015] S4: Mixing and stirring, CNC homogenizing and stirring molding time: 25min~45min.

[0016] A gynecological gel is used as a medicine for preventing pathogenic microorganisms from colonizing in the female vagina.

[0017] Technical effects and advantages of the present invention:

[0018] The gynecological gel and vaginal antibacterial gel belong to Class II medical devices, and its main component is carbomer. Carbomer is a high molecular polymer, commonly used in gel matrix, and has a thickening effect. The gel is made by combining moisturizer glycerin, stabilizer and film-forming agent sodium alginate, lubricant polyethylene glycol 4000, and pH regulator triethanolamine. By forming a protective gel film on the vaginal wall, the vaginal wall is physically isolated from external bacteria, thereby preventing the colonization of pathogenic microorganisms, which is in line with the market development trend and the concept of modern people's medication, and has far-reaching significance. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0020] Example 1

[0021] This embodiment provides a gynecological gel, which includes carbomer, a high molecular polymer, as a main gel matrix, and the carbomer as the main gel matrix is ​​combined with glycerin as a moisturizer, a stabilizer and sodium alginate as a film-forming agent, polyethylene glycol 4000 as a lubricant, and triethanolamine as a pH regulator to prepare a gel, and ethylparaben and purified water are added to the semi-finished gel;

[0022] The gel also includes a plant-derived medicinal extract that can have gynecological diuretic and antiviral effects;

[0023] The antibacterial Chinese patent medicine extract for inhibiting Escherichia coli, Candida albicans and Staphylococcus aureus is added to the semi-finished gel product.

[0024] The following ingredients and mass ratios are provided in this embodiment: 30% carbomer, 15% glycerol, 10% sodium alginate, 10% ethylene glycol 4000, 10% triethanolamine, 8% ethylparaben, and 15% purified water.

[0025] The plant-derived drug extract provided in this embodiment includes: 5% matrine, 4% cnidium monnieri, 4% phellodendron, 4% angelica sinensis, 1% safflower, 2% alum, 2% chlorhexidine, and 1% borneol.

[0026] The antibacterial Chinese patent medicine extract provided in this embodiment includes: catechu 1%, safflower 0.5%, dandelion 1%, houttuynia cordata 1%, patrinia 1%, and red peony root 0.7%.

[0027] A method for preparing a gynecological gel comprises the following steps:

[0028] S1: Weighing: weigh carbomer, glycerin, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts for each formula raw material, and place them aside after weighing according to the ratio;

[0029] S2: dissolving and stirring, dissolving the sodium alginate and polyethylene glycol 4000 prepared in S1 and stirring for 1.5 h;

[0030] S3: dissolution, carbomer dissolution time: 10h;

[0031] S4: Mixing and stirring, CNC homogenizing and stirring molding time: 25min.

[0032] A gynecological gel is used as a medicine for preventing pathogenic microorganisms from colonizing in the female vagina.

[0033] Example 2

[0034] This embodiment provides a gynecological gel, which includes carbomer, a high molecular polymer, as a main gel matrix, and the carbomer as the main gel matrix is ​​combined with glycerin as a moisturizer, a stabilizer and sodium alginate as a film-forming agent, polyethylene glycol 4000 as a lubricant, and triethanolamine as a pH regulator to prepare a gel, and ethylparaben and purified water are added to the semi-finished gel;

[0035] The gel also includes a plant-derived medicinal extract that can have gynecological diuretic and antiviral effects;

[0036] The antibacterial Chinese patent medicine extract for inhibiting Escherichia coli, Candida albicans and Staphylococcus aureus is added to the semi-finished gel product.

[0037] The present embodiment provides the following ingredients and their weight ratios: carbomer 40%, glycerol 18%, sodium alginate 13%, ethylene glycol 4000 12%, triethanolamine 11%, ethylparaben 10%, and purified water 20%.

[0038] The plant-derived drug extract provided in this embodiment includes: 10% matrine, 8% cnidium monnieri, 10% phellodendron, 5% angelica sinensis, 2% safflower, 3% alum, 3% chlorhexidine, and 2.5% borneol.

[0039] The antibacterial Chinese patent medicine extract provided in this embodiment includes: catechu 2%, safflower 0.7%, dandelion 1.2%, houttuynia cordata 1.5%, patrinia 2%, and red peony root 1.1%.

[0040] A method for preparing a gynecological gel comprises the following steps:

[0041] S1: Weighing: weigh carbomer, glycerin, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts for each formula raw material, and place them aside after weighing according to the ratio;

[0042] S2: dissolving and stirring, dissolving the sodium alginate and polyethylene glycol 4000 prepared in S1 and stirring for 2 hours;

[0043] S3: dissolution, carbomer dissolution time: 11h;

[0044] S4: Mixing and stirring, CNC homogenizing and stirring molding time: 30min.

[0045] A gynecological gel is used as a medicine for preventing pathogenic microorganisms from colonizing in the female vagina.

[0046] Example 3

[0047] This embodiment provides a gynecological gel, which includes carbomer, a high molecular polymer, as a main gel matrix, and the carbomer as the main gel matrix is ​​combined with glycerin as a moisturizer, a stabilizer and sodium alginate as a film-forming agent, polyethylene glycol 4000 as a lubricant, and triethanolamine as a pH regulator to prepare a gel, and ethylparaben and purified water are added to the semi-finished gel;

[0048] The gel also includes a plant-derived medicinal extract that can have gynecological diuretic and antiviral effects;

[0049] The antibacterial Chinese patent medicine extract for inhibiting Escherichia coli, Candida albicans and Staphylococcus aureus is added to the semi-finished gel product.

[0050] The present embodiment provides the following ingredients and their mass ratios: carbomer 45%, glycerol 20%, sodium alginate 15%, ethylene glycol 4000 13%, triethanolamine 13%, ethylparaben 12%, and purified water 25%.

[0051] The plant-derived drug extract provided in this embodiment includes: 12% matrine, 10% cnidium monnieri, 12% phellodendron, 7% angelica sinensis, 3% safflower, 4% alum, 4% chlorhexidine, and 4% borneol.

[0052] The antibacterial Chinese patent medicine extract provided in this embodiment includes: catechu 3%, safflower 1%, dandelion 1.5%, houttuynia cordata 2%, patrinia 3%, and red peony root 1.4%.

[0053] A method for preparing a gynecological gel comprises the following steps:

[0054] S1: Weighing: weigh carbomer, glycerin, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts for each formula raw material, and place them aside after weighing according to the ratio;

[0055] S2: dissolving and stirring, dissolving the sodium alginate and polyethylene glycol 4000 prepared in S1 and stirring for 3 hours;

[0056] S3: dissolution, carbomer dissolution time: 12h;

[0057] S4: Mixing and stirring, CNC homogenizing and stirring molding time: 45min.

[0058] A gynecological gel is used as a medicine for preventing pathogenic microorganisms from colonizing in the female vagina.

[0059] Specific to this case:

[0060] The gynecological gel and its preparation method and application are functionally tested on Examples 1 and 2 to obtain the gel prepared in Examples 1 and 2. Due to the different proportions of carbomer, glycerol, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts and antibacterial Chinese patent medicine extracts in the two examples, the traditional gel can be changed. A protective gel film is formed on the vaginal wall to physically isolate the vaginal wall from external bacteria, thereby preventing the colonization of pathogenic microorganisms, which is in line with the market development trend and the concept of modern people's medication, and has far-reaching significance.

[0061] Functional tests were performed on Examples 1 to 3, and the gels prepared in Examples 1 to 3 were obtained. Due to the different ratios of carbomer, glycerol, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts in the two examples, the traditional gel can be changed. By forming a layer of protective gel film on the vaginal wall, the vaginal wall is physically isolated from external bacteria, thereby preventing the colonization of pathogenic microorganisms, which is in line with the market development trend and the concept of modern people's medication, and has far-reaching significance.

[0062] The above description is only a preferred specific implementation manner of the invention, but the protection scope of the invention is not limited thereto. Any technician familiar with the technical field can make equivalent substitutions or changes within the technical scope disclosed by the invention according to the technical scheme and inventive concept of the invention, which should be covered by the protection scope of the invention.

Claims

1. A gynecological gel, comprising carbomer, a high molecular polymer, as a main gel matrix, characterized in that: Based on the carbomer as the main gel matrix, a moisturizing agent glycerin, a stabilizer and a film-forming agent sodium alginate, a lubricant polyethylene glycol 4000, and a pH regulator triethanolamine are added to form a gel, and ethylparaben and purified water are added to the semi-finished gel; The gel also includes a plant-derived medicinal extract that can have gynecological diuretic and antiviral effects; The antibacterial Chinese patent medicine extract for inhibiting Escherichia coli, Candida albicans and Staphylococcus aureus is added to the semi-finished gel product.

2. A gynecological gel according to claim 1, characterized in that: The composition and weight ratio are as follows: 30-45% of carbomer, 15-20% of glycerol, 10-15% of sodium alginate, 10-13% of ethylene glycol 4000, 10-13% of triethanolamine, 8-12% of ethyl hydroxybenzoate and 15-25% of purified water.

3. A gynecological gel according to claim 2, characterized in that: The plant-derived drug extract comprises: 5-12% of matrine, 4-10% of cnidium monnieri, 4-12% of phellodendron, 4-7% of angelica sinensis, 1-3% of safflower, 2-4% of alum, 2-4% of chlorhexidine and 1-4% of borneol.

4. A gynecological gel according to claim 3, characterized in that: The antibacterial Chinese patent medicine extract comprises: catechu 1-3%, safflower 0.5-1%, dandelion 1-1.5%, houttuynia cordata 1-2%, patrinia salsa 1-3%, and red peony root 0.7-1.4%.

5. A method for preparing a gynecological gel according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1: Weighing: weigh carbomer, glycerin, sodium alginate, ethylene glycol 4000, triethanolamine, ethylparaben, purified water, plant-derived drug extracts, and antibacterial Chinese patent medicine extracts for each formula raw material, and place them aside after weighing according to the ratio; S2: dissolving and stirring, dissolving the sodium alginate and polyethylene glycol 4000 prepared in S1 and stirring for 1.5 h to 3 h; S3: dissolution, carbomer dissolution time: 10h~12h; S4: Mixing and stirring, CNC homogenizing and stirring molding time: 25min~45min.

6. Use of the gynecological gel according to any one of claims 1 to 4 in a drug for preventing pathogenic microorganisms from colonizing in the female vagina.