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Disinfectant gellant for gynaecological external use and its preparation method

A liquid gel, gynecological technology, applied in the field of pharmaceutical compositions, can solve the problems of short residence time in the vagina, poor mucosal adhesion, low bioavailability, etc., and achieve uniform and fine texture, easy absorption, and long residence time. Effect

Inactive Publication Date: 2011-10-05
PROZIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound preparation of chlorhexidine acetate and metronidazole is a commonly used drug for the treatment of such diseases, and the commonly used dosage forms include suppositories and lotions, but the compound preparation of chlorhexidine acetate and metronidazole is only used in the treatment of early infectious diseases. The effect is more obvious, but the effect is not good in the treatment of heavier infectious diseases, and the suppository and lotion are also prone to outflow during use, short retention time in the vagina, poor adhesion to mucous membranes, contamination of clothing, and stability. Poor performance, especially low bioavailability

Method used

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  • Disinfectant gellant for gynaecological external use and its preparation method
  • Disinfectant gellant for gynaecological external use and its preparation method
  • Disinfectant gellant for gynaecological external use and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 1.6g of aloe vera gel, 5.6g of carboxymethyl cellulose, 0.6g of natural borneol, 1.5g of chlorhexidine acetate, 0.5g of metronidazole, 0.5g of surfactant, 0.15g of essence, and 100ml of ethanol, and the balance is pure water, make 1000ml.

[0020] Wet the aloe vera gel and carboxymethyl cellulose with water, dilute to about 800ml with pure water under stirring, boil, continue to stir to make it a transparent gel, and let it cool. Then take natural borneol, chlorhexidine acetate, metronidazole and essence, dissolve them in ethanol and add them into the gel transparent liquid together with surfactants, then dilute to 1000ml with pure water, stir evenly, and place it for more than 12 hours under normal pressure Degassing, subpackaging after inspection to obtain gynecological external use disinfectant gel.

Embodiment 2

[0022] Take carbomer 5g, natural borneol 1.6g, chlorhexidine acetate 3g, metronidazole 1g, surfactant 1.2g, essence 0.3g, ethanol 200ml, and the balance is purified water to make 2000ml.

[0023] Moisten the carbomer with ethanol, dilute it with pure water to about 1600ml while stirring, boil, continue to stir to make it a transparent gel, and let it cool. Then take natural borneol, chlorhexidine acetate, metronidazole and essence, dissolve them in ethanol and add them into the gel transparent liquid together with surfactants, then dilute to 2000ml with pure water, stir evenly, place for more than 12 hours, under normal pressure Degassing, subpackaging after inspection to obtain gynecological external use disinfectant gel.

Embodiment 3

[0025] Take 8.5g of hydroxyethyl cellulose, 0.75g of natural borneol, 1.6g of chlorhexidine acetate, 0.6g of metronidazole, 0.6g of surfactant, 0.15g of essence, 100ml of ethanol, and the balance is purified water to make 1000ml.

[0026] Wet the hydroxyethyl cellulose with water, dilute it with pure water to about 800ml while stirring, boil, continue to stir to make it a transparent gel, and let it cool. Then take natural borneol, chlorhexidine acetate, metronidazole and essence, dissolve them in ethanol and add them into the gel transparent liquid together with surfactants, then dilute to 1000ml with pure water, stir evenly, and place it for more than 12 hours under normal pressure Degassing, subpackaging after inspection to obtain gynecological external use disinfectant gel.

[0027] Get the gynecological external use disinfection gel obtained in Example 1 and detect according to the standard, and each index is as follows.

[0028] 1. Appearance properties: This product is...

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Abstract

The invention provides a disinfectant gellant for gynaecology external use and its preparation method, which relates to a pharmaceutical composition for external use to treat gynaecological vaginitis. The disinfectant gellant for gynaecological external use comprises a gel matrix, a penetration enhancer, a bactericide, a surfactant, essence, ethanol and purified water as balance. Each 1000 ml of the disinfectant gellant for gynaecological external use comprises 10% to 12% of gel matrix, penetration enhancer, bactericide, surfactant, essence, ethanol in proportion. The present invention has the advantages that the composite bactericide is added with the penetration enhancer based on chlorhexidine acetate and metronidazole complex formulation. Natural borneol is taken as the penetration enhancer, thereby the invention has double effects of penetrating promotion and sterilization. The invention has the characteristics of wide spectrum, strong sterilization capability and strong nursing capability, as well as the invention employs the gallant for external use.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an external pharmaceutical composition for treating gynecological vaginitis. Background technique [0002] Gynecological vaginitis is a common and frequently-occurring disease in gynecological diseases. After the patient is ill, itching of the vulva is unbearable, vaginal secretions increase, with peculiar smell, and repeated attacks will bring serious consequences to women's physical and mental health. At present, the compound preparation of chlorhexidine acetate and metronidazole is a commonly used drug for the treatment of such diseases, and the commonly used dosage forms include suppositories and lotions, but the compound preparation of chlorhexidine acetate and metronidazole is only used in the treatment of early infectious diseases. The effect is more obvious, but the effect is not good in the treatment of heavier infectious diseases, and the suppository and lotion are also p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/00A61K31/4164A61K31/155A61K47/38A61P15/02A61K47/36
Inventor 肖军平吴永忠郭峰李旭刘立鼎
Owner PROZIN PHARMA CO LTD
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