Flupentixol and melitracen medicinal composition and preparation thereof

A technology of melitracen and flupentixol, applied in the field of pharmaceutical preparations, can solve problems such as inability to guarantee product stability, and achieve the effects of ensuring product safety and effectiveness, reducing impurity levels, and enhancing stability
CN109674754AActive Publication Date: 2019-04-26GUANGDONG SCI FINDER PHARMA TECH CO LTD +1
7 Cites 11 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGDONG SCI FINDER PHARMA TECH CO LTD
Publication Date
2019-04-26

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a flupentixol and melitracen medicinal composition and a preparation thereof, and belongs to the technical field of pharmaceutical preparations. The flupentixol and melitracenmedicinal composition is prepared from flupentixol dihydrochloride, melitracen hydrochloride and an antioxidant. The flupentixol and melitracen medicinal composition disclosed by the invention has the advantages that by adding the antioxidant, the stability of a flupentixol and melitracen compound preparation can be effectively enhanced, and impurities such as Lu28-159 and trifluoromethyl thioxanthone produced by degrading flupentixol can be effectively controlled, so that impurity level is reduced and the safety and the effectiveness of a product are ensured; flupentixol and melitracen medicinal tablets prepared by the preparation method disclosed by the invention have similar in-vitro dissolution behavior and bioequivalence with original research tablets Deanxit.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a flupentixol melitracen pharmaceutical composition and a preparation thereof, belonging to the technical field of pharmaceutical preparations. Background technique

[0002] Usually, the stability of a pharmaceutical composition is a very important consideration during the design, manufacture, and storage of the pharmaceutical composition. Drugs with poor stability may be degraded into certain degradation products, causing unnecessary side effects or reducing the efficacy or bioavailability of the drug itself, making it difficult to achieve satisfactory results.

[0003] Flupenthixol hydrochloride is the hydrochloride form of flupenthixol, an atypical antipsychotic drug. It is a thioxanthene derivative, which has a powerful effect of blocking dopamine receptors, and has anxiolytic and antidepressant effects in small doses. Its chemical name is: 2-[4-[3(EZ)-(2-trifluoromethylthioxanthene-9-yllidene)propyl]piperazin-1-yl]ethanol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More