Whole mouth malodor control by a combination of antibacterial and deodorizing agents

Abstract

Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure (I) wherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, -OH or -ORa; R4 is -OH, -ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from a-damascenone, a-isomethylionone, a-ionone, ss-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde. The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.

Description

technical field [0001] The present invention relates to oral care compositions comprising an antimicrobial agent and a deodorant or odor neutralizer to provide overall oral malodor control. Background of the invention [0002] Oral malodor, also known as halitosis, is a commonly experienced condition with multiple etiological factors. The condition can have a variety of causes including prolonged fasting, oral pathology such as gingivitis or periodontitis, and ENT origins such as sinusitis. However, even individuals without oral or non-oral pathology can experience periodic halitosis, which can persist for hours (or even days) after ingesting foods containing certain odorants, such as garlic and onions. Although many non-oral sites and many different causes have been associated with halitosis, it has been estimated that 80% to 90% of all halitosis odors originate in the oral cavity, and bacteria are the direct cause of most irritating gases. The decay of sulfur-containing ...

AI Technical Summary

Problems solved by technology

Data from this study explain the recalcitrant nature of garlic breath; even vigorous oral hygiene did not prevent the removal of allyl methyl sulfide from the breath of subjects consuming garlic

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