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Multifunctional microporous styptic powder and preparation method thereof

A technology of hemostatic powder and starch, which is applied in the field of natural biomedical materials, can solve the problems of limited liquid absorption effect and low porosity of composite microporous polysaccharide particles, and achieve a simple method, enhanced hemostatic effect, and strong controllability Effect

Active Publication Date: 2016-06-01
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite microporous polysaccharide particles made by the cross-linking method in the patent have low porosity and limited liquid absorption effect, and are only suitable for wounds with bleeding or diffuse bleeding, not for wounds with large bleeding volume

Method used

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  • Multifunctional microporous styptic powder and preparation method thereof
  • Multifunctional microporous styptic powder and preparation method thereof
  • Multifunctional microporous styptic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, preparation multifunctional microporous hemostatic powder

[0049] (1) Preparation of carboxymethyl starch paste: carboxymethyl starch (2% aqueous solution viscosity at 25°C is 500mpas, degree of substitution is 0.5) is mixed with water in a mass ratio of 1:40, and placed in a 30°C Stir in a water bath to make it fully dissolved to obtain a carboxymethyl starch paste.

[0050] (2) Preparation of carboxymethyl chitosan solution: carboxymethyl chitosan (at 25°C, viscosity of 1% aqueous solution is 100mpas, degree of substitution is 80%) is mixed with water in a mass ratio of 1:60 and Fully dissolve, and filter the insoluble matter to obtain a carboxymethyl chitosan solution for subsequent use.

[0051] (3) The carboxymethyl starch paste liquid and the carboxymethyl chitosan solution were blended at a ratio of 1:1 to obtain a blended solution.

[0052] (4) Dispersed porogen: disperse corn gluten with a particle size of 5 μm into the blended solution in step...

Embodiment 2

[0057] Example 2, preparation of multifunctional microporous hemostatic powder

[0058] (1) Preparation of pregelatinized starch paste: mix pregelatinized starch (the viscosity of 2% aqueous solution at 25°C is 200mpas) with water at a mass ratio of 1:25, and place it in a water bath at 50°C to stir and swell fully A pregelatinized starch paste is prepared.

[0059] (2) Preparation of carboxymethyl chitosan solution: carboxymethyl chitosan (at 25°C, the viscosity of 1% aqueous solution is 200mpas, and the degree of substitution is 80%) is mixed with water in a mass ratio of 1:30 and fully dissolve, and filter the insoluble matter to obtain a carboxymethyl chitosan solution for subsequent use.

[0060] (3) The starch paste liquid and the carboxymethyl chitosan solution were blended at a ratio of 1:1 to obtain a blended solution.

[0061] (4) Dispersed porogen: CaCO with a particle size of 2 μm 3 Disperse into the blended solution in step (3), porogen: polysaccharide solid co...

Embodiment 3、 Embodiment 1 and Embodiment 2

[0066] The performance test of embodiment 3, embodiment 1 and embodiment 2 multifunctional microporous hemostatic powder

[0067] (1) Water absorption rate test

[0068] Water absorption rate test: Weigh 0.1g sample (W 0 ) into about 10.0 g of purified water, and after the hemostatic powder swells for about 5 minutes to saturate the water absorption, it is centrifuged at 500 rpm for 10 minutes, and weighed to obtain W 1 . Water absorption ratio = (W 1 -W 0 ) / W 0 ×100%. The samples were the hemostatic powder prepared in Example 1, the hemostatic powder prepared in Example 2, and a certain compound hemostatic powder on the market (Shandong Saikesaisi Pharmaceutical Technology Co., Ltd. "instantaneous" composite microporous polysaccharide hemostatic powder ) and a certain starch hemostatic powder on the market (Hangzhou Xiehe Medical Supplies Co., Ltd. "Xinsuling" MPH absorbable hemostatic microspheres).

[0069] Table 1. Results of water absorption ratio

[0070] ...

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Abstract

The invention discloses multifunctional microporous styptic powder and a preparation method and application thereof. The preparation method comprises the following steps: 1) mixing starch with water to obtain a starch solution or starch pasty liquid; 2) mixing carboxymethyl chitosan with water to obtain a carboxymethyl chitosan solution; 3) mixing the starch solution or the starch pasty liquid with the carboxymethyl chitosan solution to obtain a blended solution; 4) dispersing a pore-forming agent into the blended solution to obtain blended dispersion liquid; 5) dropwise adding an ionic crosslinker into the blended dispersion liquid under a stirring condition, mixing the obtained mixed system with a dispersing agent and an emulsifying agent, and performing crosslinking reaction and suction filtration; 6) removing the pore-forming agent from a product obtained in the step 5), and drying; 7) performing microwave treatment on a product obtained in the step 6) to obtain the styptic powder. The preparation method adopts a dual crosslinking method of ionic crosslinking and microwave treatment; used reagents are environmentally friendly, and free of residues; the biological activity of an amino group in the carboxymethyl chitosan can be retained easily.

Description

technical field [0001] The invention relates to a multifunctional microporous hemostatic powder and a preparation method thereof, belonging to the field of natural biomedical materials. Background technique [0002] With the rapid development of basic medical theory, surgical technology and equipment, the scope and types of surgery have been continuously expanded. Bleeding is a common problem in surgical operations. Excessive bleeding can even be life-threatening. Blood transfusion not only has problems such as high cost and insufficient blood source, but also has the risk of infection of blood diseases such as hepatitis C or HIV. Therefore, how to quickly and effectively stop bleeding is of great significance for improving the success rate of surgery, reducing the cost of medical treatment for patients, and alleviating the shortage of blood supply. However, traditional methods of hemostasis, such as compression, ligation, suture, electrocautery, etc., are far from being ab...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00C08J9/26C08J3/24
CPCA61L24/0015A61L24/0036A61L24/043A61L2300/232A61L2300/404A61L2300/412A61L2300/602A61L2400/04C08J3/246C08J9/26C08J2201/0424C08J2201/0444C08J2303/08C08J2305/08C08J2403/08C08J2405/08
Inventor 周颖郭刚孙先昌赵庆凯徐秀
Owner YANTAI ZHENGHAI BIO TECH
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