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Surface modification method and application of porous material

A porous material and surface modification technology, applied in the field of surface modification of porous materials, can solve the problems of poor stability of surface coating, difficult modification, poor biocompatibility, etc., to overcome poor mechanical strength, improve surface hydrophilicity, enhance The effect of stain resistance

Inactive Publication Date: 2018-01-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the shortcomings of existing porous materials such as poor biocompatibility, difficult modification, and poor surface coating stability, the present invention utilizes zwitterionic materials for the first time, and prepares zwitterionic hydrogels to modify the surface of porous materials

Method used

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  • Surface modification method and application of porous material
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  • Surface modification method and application of porous material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Modification of polystyrene (PS) electrospun fiber membrane with zwitterionic acrylamide carboxybetaine (CBAA) hydrogel:

[0050] The structural formula of CBAA monomer is as follows:

[0051]

[0052] The polystyrene (PS) fiber membrane was prepared by general electrospinning technology, immersed in ethanol for 2 min, then taken out, and the ethanol on the surface was removed with filter paper. Take 1mL of 1M sodium chloride aqueous solution, add 699mg of carboxybetaine acrylamide monomer, then add 4.4mg of cross-linking agent N,N'-methylenebisacrylamide, initiator 2-hydroxy-2-methyl- 1.8 mg of 1-phenyl-1-acetone, dissolved until it becomes a homogeneous solution, the mass percentages of the above components are as follows:

[0053]

[0054] Then put the PS fiber membrane into the solution, ultrasonically infiltrate it for 20 minutes at an ultrasonic frequency of 30 Hz, take it out, remove the solution on the surface of the fiber membrane with filter ...

Embodiment 2

[0055] Example 2: Modification of polyvinyl chloride (PVC) electrospun fiber tubes with zwitterionic carboxybetaine methacrylamide (CBMAA) hydrogel:

[0056] The structural formula of CBMAA monomer is as follows:

[0057]

[0058] The PVC fiber tube was prepared by general electrospinning technology, which was immersed in ethanol for 2 min and then taken out. Take 2 mL of deionized water, add 820 mg of carboxybetaine methacrylamide monomer, then add 28.57 mg of cross-linking agent glycerol diacrylate, and 8.57 mg of initiator benzyl dimethyl ether, and dissolve until it becomes a uniform solution. Component mass percentages are as follows:

[0059]

[0060] Then put the PVC fiber tube into the solution, ultrasonically infiltrate it for 30 minutes at an ultrasonic frequency of 20 Hz, take it out, and use a low flow rate nitrogen flow to purge for 20 s to remove excess solution on the inner and outer tube walls, and put the fiber tube into a 37°C ultraviolet Cross-link i...

Embodiment 3

[0061] Example 3: Modification of biomedical porous titanium with zwitterionic carboxybetaine methacrylate-1 (CBMA-1) hydrogel

[0062] The structural formula of CBMA-1 monomer is as follows:

[0063]

[0064] Take 1M sodium chloride aqueous solution, add carboxybetaine methacrylate-1 (CBMA-1) monomer 990.2mg, then add crosslinking agent polyethylene glycol diglycidyl ether 5.4mg, add initiator ammonium persulfate 2mg , N,N,N',N'-Tetramethylethylenediamine 1mg, dissolved until it becomes a uniform solution, the mass percentage of the above components is as follows:

[0065]

[0066] Then put biomedical porous titanium into the mixed solution, take it out after ultrasonic infiltration at an ultrasonic frequency of 40Hz for 40min, remove the solution on the surface of biomedical porous titanium sheet with filter paper, and put the biomedical porous titanium sheet into a 37°C thermostat for cross-linking After 60 minutes, take it out to obtain biomedical porous titanium mo...

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Abstract

The invention relates to a surface modification method and application of a porous material. The surface modification method of the porous material comprises the following steps: soaking the porous material in a zwitter-ion reaction solution and fully wetting the porous material; and taking out the wetted porous material and carrying out crosslinking to obtain a zwitter-ion hydrogel modified porous material. The zwitter-ion reaction solution comprises 10-50% of zwitter-ion monomers, 0.01-5% of a crosslinking agent, 0.01-0.5% of an initiator and a solvent. The method is a universal surface modification method; a modification process is simple and convenient; a modified coating can be stable in a complicated biotic environment for a long time, the modified surface has a certain pore structure, therefore, the porous material loaded with a water-soluble and hydrophobic drug can be modified, and the purposes of releasing the drug in a sustained manner and improving the bioavailability of the drug are achieved; and the surface modification method can be used for modifying surfaces of porous metal or alloy, and is applied to repair or replacement of materials such as skin, cardiac valves,bones, cartilages or vascular tissues.

Description

technical field [0001] The invention relates to a surface modification method and application of a porous material. It specifically involves the use of zwitterionic hydrogels to modify the surface of porous materials such as hydrophobic polymer electrospun fiber structures, filter paper, biomedical porous titanium and titanium alloys, and apply them to tissue engineering scaffolds, artificial blood vessels, Catheters, wound accessories, drug carriers, implant materials and other biomedical fields. Background technique [0002] A porous material is a material with a network structure of interconnected pores. Compared with non-porous materials, porous materials have the characteristics of low relative density, small mass, and good permeability, and have been widely used in many biomedical fields. For example, in the field of medical wound dressings, wound dressings made of gauze with porous materials, hydrogel, or electrospun non-woven fabrics of hydrophilic polymers have th...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/18A61L27/16A61L27/56A61L27/52A61L27/60A61K47/34A61K47/32D06M14/32D06M14/28
Inventor 张雷许瞳张嘉敏潘超杨静朱迎男
Owner TIANJIN UNIV
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