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Soluble stanching gauze and preparation method thereof

A hemostatic gauze, soluble technology, applied in the field of medicine, can solve the problems of needing to be washed off with normal saline or distilled water, cannot solve postoperative adhesion, cannot be used as a hemostatic agent, etc., and achieve the effect of protecting the wound surface, good hygroscopicity, and easy absorption

Inactive Publication Date: 2009-07-29
HENAN FENGHUANG DRUGS MFR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the invention patents with Chinese patent numbers 91110511 and 9810676 provide soluble gauze that can fill and cover various wounds, promote platelet coagulation, and achieve the purpose of hemostasis. Solve the problem of postoperative adhesion
In addition, the Chinese patent number is 02135172.4 and the application number is 200510135361.8 invention patent. The soluble hemostatic gauze provided has anti-inflammatory and analgesic effects while hemostasis. toxic side effect
And the above-mentioned gauzes are all used as medical equipment supplies, but not as hemostatic agents

Method used

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  • Soluble stanching gauze and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. 23.8kg sodium hydroxide is prepared into a 45% solution with 95% ethanol and purified water, 31.02kg of chloroacetic acid is prepared with 95% ethanol and purified water into a 75% solution, and 95% ethanol is diluted respectively into 75% and 85% ethanol solutions.

[0024] 2. Add 13.2kg of degreased gauze and purified water into the reaction tank at a ratio of 1:100, turn the degreased gauze around the roller, wash with water for 1 hour, and let it stand naturally for 1.5 hours.

[0025] 3. Add the prepared sodium hydroxide solution into the reaction tank, heat to 25°C, and react for 1 hour.

[0026] 4. Add the prepared chloroacetic acid solution into the reaction tank, heat to 27°C, react for 4 hours for etherification, and then discharge the reaction solution.

[0027] 5. Add 75% ethanol into the reaction tank, rinse for 25 minutes, and then discharge the ethanol.

[0028] 6. Add 85% ethanol to the reaction tank, add 1% phenolphthalein and 1% bromophenol blue a...

Embodiment 2

[0034] Sodium hydroxide is mixed with 50% concentration, and other steps are identical with embodiment 1.

Embodiment 3

[0036] Chloroacetic acid is formulated into the concentration of 80%, and other steps are identical with embodiment 1.

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Abstract

The invention relates to a hemostatic medicament, in particular to a soluble hemostatic gauze and a preparation method thereof. The soluble hemostatic gauze contains an absorbent gauze, sodium hydroxide, and sodium carboxymethyl cellulose which is generated by, reaction of chloroactic acid in an alcohol solvent; and the weight ratio of the three raw material components is 1: 1.8: 2.35. The methodfor preparing the soluble hemostatic gauze comprises the following steps of water scrubbing, alkalization, etherification, alcohol washing, neutralization, and drying as well as weighing, cutting, and packaging after a prepared semi-finished product is qualified through the inspection. The soluble hemostatic gauze can be applied to exodontia, dermatological surgery, trauma hemostasis, and wound surface protection.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a soluble hemostatic gauze and a preparation method thereof. Background technique [0002] At present, the hemostatic agents used in surgical operations and wound bleeding are usually injection and external application. The earlier hemostatic agents, Yunnan Baiyao and other external application hemostatic agents have a slow hemostatic speed and ineffective effect; in recent years, the hemostatic agents that use shrimp shells as raw materials Medicine can quickly stop bleeding, but the process is complicated and the cost is high. [0003] Hemostatic gauze is widely used in the medical and health field, but the gauze will stick to the wound during use, which is easy to cause secondary trauma, and the waste after use will pollute the environment. In response to the above problems, since the early 1990s, soluble hemostatic gauzes have come out one after another. For example, the invention p...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/62D06M11/38D06M13/21D06M101/06
Inventor 黄兴文王学洲
Owner HENAN FENGHUANG DRUGS MFR
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