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Anti-tumor traditional Chinese medicinal composition and preparation method and medicinal preparation thereof

A technology of traditional Chinese medicine preparations and compositions, applied in the field of research and development of new traditional Chinese medicines, can solve the problems of low extraction rate of total alkaloids and no clear description of the content of total alkaloids in bitterwood extracts, and achieve the effect of improving the purity

Active Publication Date: 2008-01-09
北大世佳科技开发有限公司
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Problems solved by technology

The Chinese patent with publication number CN1686333A discloses a bitterwood injection preparation and its preparation method. The patent adopts alkaline ethanol extraction, gradient acid water precipitation to remove impurities, and obtains bitterwood extract, but does not clearly state that bitterwood extract The content of total alkaloids in , and the extraction rate (1.46%) of the total alkaloids disclosed in the instructions is lower

Method used

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  • Anti-tumor traditional Chinese medicinal composition and preparation method and medicinal preparation thereof

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Embodiment 1

[0056] The preparation method of embodiment 1 bitter wood extract

[0057] Take the bitter wood medicinal material and grind it, reflux extraction with 10 times the weight of the medicinal material for 3 times to obtain the extract; directly mix the extract with DM301 resin, stir evenly, and evaporate the solvent to obtain a dry sample A; directly load the sample A on the Installed on the DM301 resin column; after dry loading, use 7 times column volume of water to elute impurities; then use 16 times column volume of 40% ethanol to elute the total alkaloids adsorbed on the resin column; wash The liquid is removed, concentrated under reduced pressure, dried in vacuum, and pulverized to obtain the bitterwood extract; the content of total alkaloids in the extract is 60%.

Embodiment 2

[0058] The preparation method of embodiment 2 bitter wood extract

[0059] Take the bitter wood medicinal material and pulverize it, reflux extraction with 0.5% hydrochloric acid aqueous solution 10 times the weight of the medicinal material for 3 times to obtain the extract; directly mix the extract with D101 resin, stir evenly, evaporate the solvent to dryness, and obtain dry sample A; Loaded on the D101 resin column that has been installed; after dry loading, use 6 times the column volume of 20% ethanol to elute the impurities; then use 12 times the column volume of 60% ethanol to elute the bitter wood adsorbed on the resin column Total alkaloids; the eluate was concentrated under reduced pressure, dried and pulverized to obtain a bitterwood extract; the content of total alkaloids in the extract was 72%.

Embodiment 3

[0060] The preparation method of embodiment 3 bitter wood extract

[0061] Take the bitter wood medicinal material and pulverize it, extract it by percolation with 40% ethanol which is 12 times the weight of the medicinal material, and obtain the extract solution; directly mix the extract solution with AB-8 resin, stir evenly, evaporate the solvent to dryness, and obtain dry sample A; Load on the installed AB-8 resin column; after dry loading, use 40% ethanol of 4 times column volume to elute impurities; then use 10 times column volume of 80% ethanol to elute impurities adsorbed on the resin column The total alkaloids of the bitter wood; the eluate is concentrated under reduced pressure, dried and pulverized to obtain the bitter wood extract; the content of the total alkaloids in the extract is 56%.

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Abstract

The present invention relates to a picrasma quassioides extract obtained by using Chinese medicinal material picrasma quassioides as raw material and adopting solvent extraction and resin separation and purification processes. The total alkaloid content in said extract is above 50%. Said invention also provides a pure Chinese medicine preparation containing said picrasma quassioides extract for resisting tumor and its concrete preparation method.

Description

technical field [0001] The invention belongs to the technical field of research and development of new traditional Chinese medicines. In particular, it relates to a total alkaloid extract of bitter wood extracted and separated from Chinese medicinal material bitter wood, as well as a preparation method and a pharmaceutical preparation thereof. The traditional Chinese medicine composition has good antitumor activity. Background technique [0002] According to the report of the World Health Organization in 1997, in 1996, among the 5.8 billion people in the world, about 6.3 million people died of cancer, accounting for about 12% of the total number of deaths, of which nearly 60% died of lung cancer, gastric cancer, liver cancer, esophageal cancer, etc. Second leading cause of death after cardiovascular disease. Since 1996, more than 10.3 million cancer patients have been newly diagnosed in the world every year. The World Health Organization reported in 2001 that the incidence...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/4375A61P35/00C07D471/06A61K127/00A61K135/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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