Application of a kind of lychee grass water extract radiotherapy sensitizer

Abstract

The invention provides the application of a radiotherapy sensitizer of the lychee grass water extract. The invention uses the lychee grass water extract as a radiotherapy sensitizer to inhibit the growth of tumor tissues of colorectal cancer CT26 cell line tumor-bearing mice. The use of lychee grass water extract as a radiotherapy sensitizer significantly improved the general activity of CT26 cell transplanted tumor model mice, inhibited the growth of tumor tissue, reduced tumor weight, and had a significant inhibitory effect on the growth and proliferation of colorectal cancer. The mechanism of action is related to the down-regulation of the expression of VEGF and Survivin in tumor tissues of mice transplanted with CT26 cells. The invention further expands the application of the water extract of lychee grass, clarifies the effect of the radiotherapy sensitizer of the water extract of lychee grass on inhibiting colorectal cancer, and provides an effective means for clinical tumor treatment by adopting the method of assisting radiotherapy with traditional Chinese medicine.

Description

technical field [0001] The invention relates to the technical field of radiotherapy sensitizers, in particular to the application of a radiotherapy sensitizer of lychee grass water extract. Background technique [0002] Colorectal cancer is a cancer formed by abnormal growth of cells in the colon or rectum. It has the characteristics of high malignancy, easy metastasis and infiltration, poor prognosis and low 5-year survival rate. It is a common malignant tumor of the gastrointestinal tract in clinical practice. Most of the patients have developed to the advanced stage or have metastases when they come to the doctor. Although the conventional surgical resection can control the primary lesion, the prognosis is still poor. Radiation therapy is an important measure to control malignant tumors, which can control the growth and proliferation of tumors in time. However, radiotherapy for colorectal cancer has problems such as tumor radioresistance and normal tissues and organs arou...

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Problems solved by technology

Studies have reported that lychee herb extract has pharmacological effects such as antibacterial, anti-inflammatory, anti-oxidant, anti-viral, relieving cough and asthma, and reducing bone loss, but there is no literature report on whether it has anti-tumor effect

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