Antineoplastic Chinese traditional compound and the preparation and the method for producing the same

A pharmaceutical preparation and anti-tumor technology, which is applied in the field of research and development of new traditional Chinese medicines, can solve the problems of large environmental pollution, large amount of acid and alkali usage, and low technical content, and achieve the effects of low cost, convenient operation, and simple preparation process

Active Publication Date: 2007-09-26
北大世佳科技开发有限公司
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Problems solved by technology

Another Chinese patent with the publication number CN1457778A discloses the oral preparation, preparation method and application of the root of the mountain bean root, mainly relates to an oral preparation for protecting the liver and protecting the liver made from ...

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Embodiment 1

[0072] Embodiment 1: The preparation method of the active part of the total alkaloids of bean root

[0073]The medicinal material is crushed into a coarse powder passing through a 20-mesh sieve, and each time 8 times the weight of the medicinal material (V / W) is refluxed and extracted for 1 hour, a total of 3 times. Concentrate, this concentrate is acidified with hydrochloric acid to pH 3 ~ 4 and then centrifuged (4000r / min, 10min), the supernatant obtained is loaded on the 732 cation exchange resin column that has been treated, first with 13 times the medicinal material weight (V / W ) of water, and 7.8 times of 30% ethanol by weight of medicinal material (V / W) to elute impurities, then use 25% ammonia water of 1.3 times of medicinal material weight (V / W), to alkalize 732 cation exchange resin, and finally use 7.8 Elute with 30% ethanol twice the weight of the medicinal material (V / W), desorb, collect the desorbed solution, concentrate under reduced pressure, and then vacuum-dr...

Embodiment 2

[0074] Embodiment 2: The preparation method of the active part of the total alkaloids of Soba root

[0075] The medicinal material is crushed into a coarse powder passing through a 20-mesh sieve, soaked in 40% ethanol 5 times the weight of the medicinal material (V / W) for 2 hours, put into a percolation bucket, percolated with 40% ethanol, collect the percolation liquid, and recover it under reduced pressure Solvent to obtain a concentrated solution with a relative density of 1.10 to 1.15. The concentrated solution was acidified with hydrochloric acid to pH 3 to 4 and then centrifuged (4000r / min, 10min). The obtained supernatant was loaded on the treated AB-8 resin column. Use 15 times the weight of the medicinal material (V / W) of water, and 10% of the weight of the medicinal material (V / W) of ethanol to elute the impurities, and then use 20% of the weight of the medicinal material (V / W) of ammonia, alkali Add AB-8 resin, and finally elute with 20% ethanol of 8 times the weigh...

Embodiment 3

[0076] Embodiment 3: the preparation method of the active part of the total alkaloids of bean root

[0077] The medicinal material is crushed into a coarse powder passing through a 20-mesh sieve, soaked with 20% ethanol 10 times the weight of the medicinal material (V / W) for 12 hours, filtered, and the filter residue is soaked with 30% ethanol for 12 hours, the two soaking solutions are combined, and the solvent is recovered under reduced pressure A concentrated solution with a relative density of 1.10 to 1.15 was obtained, which was acidified with 5% sulfuric acid to pH 3 to 4 and then centrifuged (4000r / min, 10min). 10 times the weight of medicinal material (V / W) of water, and 20% ethanol of 8 times the weight of medicinal material (V / W) to elute impurities, then use 1.5 times the weight of medicinal material (V / W) of 15% sodium hydroxide solution, alkali The Nad101 resin is finally eluted with 50% ethanol of 6 times the weight of the medicinal material (V / W), desorbed, and ...

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Abstract

The invention relates to an antineoplastic Chinese medicinal composition and preparing process thereof, wherein the composition has appreciable effect in treating malignant tumor such as digestive tract tumor. The invention provides the significant part of subprostrate sophora root alkaloids extracted from subprostrate sophora root and the related preparing process. The alkaloids content in the subprostrate sophora root alkaloid significant part is higher than 50%. The invention further provides a Chinese medicinal preparation using subprostrate sophora root alkaloids as the medicinal effective composition.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. It relates to an anti-tumor traditional Chinese medicine composition as well as a preparation and a preparation method thereof. Background technique [0002] Malignant tumor is a new organism formed by the gradual and persistent abnormal proliferation of local tissue cells under the long-term action of various internal and external carcinogenic factors. With the continuous progress of the economy, environmental industrialization and urbanization, the aging of the population and unhealthy lifestyles and behaviors, the incidence and mortality of malignant tumors are increasing year by year, and the prevention and treatment of malignant tumors has become the focus of all countries in the world. important topic. In 1980, it was estimated that there were 6.35 million new cases of malignant tumors in the world every year, including 3.13 million cases in dev...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/08A61K9/16A61K9/20A61K9/48A61P35/00A61K125/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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