Preparation of dendrobium officinale polysaccharide lozenge and application of dendrobium officinale polysaccharide lozenge in immunopotentiation

Abstract

The invention discloses preparation of a dendrobium officinale polysaccharide lozenge and an application of the dendrobium officinale polysaccharide lozenge in immunopotentiation. The total extractionprocess of the polysaccharide comprises the following steps: decocting and extracting dendrobium officinale coarse powder with 40 times of water for 2 hours, filtering, concentrating the filtrate to0.2 g of crude drug / ml, and precipitating with 5 times of ethanol by a water extraction and alcohol precipitation method to obtain the dendrobium officinale polysaccharide powder. The mannitol, aspartame, magnesium stearate, microcrystalline cellulose, menthol and povidone are added into the dendrobium polysaccharide powder to prepare lozenge. The lozenge can improve yin deficiency symptoms of yindeficiency model mice caused by thyroid hormone. Peripheral blood leukocyte WBC reduction of S180 tumor-bearing mice caused by 60Co radiotherapy is improved, and the number of bone marrow nucleated cells is increased. The effects of improving the activity of the body, resisting oxidative damage and enhancing immunity are shown. The dendrobium officinale polysaccharide lozenge prepared by the optimal dendrobium officinale polysaccharide extraction process screened by the invention has an obvious immunopotentiation effect, and can be used in the fields of immunopotentiation medicines, health-care products and foods.

Description

technical field [0001] The invention relates to the technical fields of medicine, food and health products, in particular to the preparation of dendrobium officinale polysaccharide buccal tablet and its application in immune enhancement. Background technique [0002] Immunity is the body's own defense mechanism, which is the body's ability to recognize and eliminate any foreign matter (viruses, bacteria, etc.) . The immune characteristics of newborns often show that the immune system is immature, the function is not yet perfect, and they have not been exposed to various pathogens in the environment outside the uterus, nor have they been exposed to a wide variety of antigenic substances such as food proteins. Pregnancy is affected by the mother's antibodies passing through the placenta, so that the newborn is physiologically immunocompromised. At present, there are many ways to improve immunity. Among them, Mopanshi is relatively simple and effective. Pay more attention to ...

AI Technical Summary

Problems solved by technology

①Fresh use: Affected by the season, it cannot be used in non-harvesting seasons; and freshly used Dendrobium officinale is very dry, causing side effects such as diarrhea; ②Rolled into iron maple buckets: the processing cost is high, and sometimes the labor cost exceeds the cost of the medicinal material itself Procurement cost; moreover, the patient needs to cook for a long time (2 hours) when taking it, and it is inconvenient to use; ③ make Dendrobium candidum oral liquid: it is convenient to take, but the stability is poor, which seriously affects its effectiveness

Especially the dendrobium products, whose active ingredients are mainly polysaccharides, have poor storage stability in aqueous solution, and the active ingredients are easy to precipitate, resulting in a decrease in effectiveness

Moreover, in order to keep the preparation from growing mold, it is often necessary to add a certain amount of preservative in the preparation, so its safety is affected to a certain extent.

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