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Medicinal simulation calculus bovis and manufacturing method thereof

A bezoar and simulation technology, which is applied in medical formulas, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of different types and contents of natural bezoar, discrepancies in actual conditions, and low dosage of bilirubin

Inactive Publication Date: 2010-08-18
石朝周
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantages of this "artificial bezoar" are: (1) the formula is too simplified and the purity of the ingredients is low; (2) the amount of bilirubin is too low, and it is all free bilirubin; (3) there are some The ingredients do not actually exist in natural bezoar (such as hyodeoxycholic acid and starch); (4) The type and existence state or form of the ingredients in the prescription are inconsistent with the actual situation of natural bezoar; (5) the drug effect is lower than that of natural bezoar
But production cost is higher, and its main reason is that the bilirubin consumption of price is too big; Another shortcoming is, the chemical composition in the product, composition ratio and component exist form, have more significant difference with natural bezoar (especially The type and content of conjugated bile acids are significantly lower than those of natural bezoar)
Another disadvantage is that hyodeoxycholic acid is used as an ingredient in the same prescription as the ministerial prescription

Method used

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  • Medicinal simulation calculus bovis and manufacturing method thereof
  • Medicinal simulation calculus bovis and manufacturing method thereof
  • Medicinal simulation calculus bovis and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Embodiment 1 Medicinal artificial bezoar formula of the present invention

[0140] The composition of the present invention's medicinal imitation bezoar formula and component source and proportioning are as follows:

[0141]

[0142]

[0143] ※ Mr stands for relative molecular mass; PI stands for isoelectric point; CA stands for total cholic acid.

Embodiment 2

[0144] Embodiment 2: preparation bilirubin calcium salt

[0145] Add 500ml of distilled water and 2g of sodium bisulfite to a 1L beaker, add 45g of bilirubin with a purity of ≥90% and an appropriate amount of NaOH in the dark to make the pH of the mixture reach 11-12, and gradually add it dropwise when the bilirubin is completely dissolved 6mol / LCaCl 2 solution until the precipitation is complete. Heat and stir in a 70°C water bath for 10 minutes, cool to room temperature and place in a 0°-5°C refrigerator overnight. The next day, the orange-red crystals were collected by filtration, washed with distilled water until there were no chloride ions, then washed with absolute ethanol and acetone for 1-2 times, drained, and placed in a container containing P 2 o 5 Dry under reduced pressure in a vacuum desiccator for 2 to 3 days to obtain about 39 g of orange red bilirubin calcium salt with a purity of ≥95%.

Embodiment 3

[0146] Embodiment 3: Preparation of medicinal artificial bezoar solid product of the present invention

[0147] Get 38g of bilirubin calcium salt fine powder, add mucin, deoxycholic acid, sodium glycocholate, sodium taurocholate, sodium taurodeoxycholate, ox bile extract powder and zinc sulfate according to the formula. Grind with 100ml of 0.2% sodium bisulfite aqueous solution in a mortar and adjust it into a paste, then add free bilirubin, lecithin, cholesterol and 150ml of anhydrous hot ethanol in a formula amount, stir evenly, evaporate the solvent under reduced pressure, Then vacuum-dry to obtain an orange-red solid, which is the medicinal imitation bezoar solid product of the present invention, which is sealed and packaged in a brown bottle for subsequent use.

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Abstract

The invention provides a medicinal simulation calculus bovis; compared with the existing other artificial calculus bovis, the medicinal simulation calculus bovis is characterized in that the medicinal simulation calculus bovis uses calcium bilirubinate as main component, a relatively large amount of conjugated bile acid (glycocholic acid, taurocholic acid, and the like) is added, proteins (comprising mucoprotein, polypeptide, and the like) and lecithin are used as component substances, the hyodeoxycholic acid in the traditional formula of artificial calculus bovis is removed so as to reduce the ratio of free cholesteric acid, the technology of preparing calcium bilirubinate with a bacterial fermentation method is eliminated and starch is removed as accessory, and the compound ratio and existing manner in the formula is almost completely the same as natural calculus bovis. The medicinal simulation calculus bovis has better drug effect than the existing other artificial calculus bovis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to the imitation technology of natural Chinese medicinal materials, in particular to the imitation of natural bezoar. Background technique [0002] Overview of research and development of bezoar and its substitutes [see references 1-9] [0003] 1. The use and chemical composition of bezoar [0004] Bezoar or natural bezoar is the gallbladder or bile duct stones of sick cattle. It has the effects of clearing heart and resuscitation, clearing away heat and detoxification, anti-inflammatory, calming convulsions, calming and sleeping. According to the records of medical literature in my country, there are more than 160 famous prescriptions of traditional Chinese medicine that use bezoar as the main component of the prescription, and make it into a Chinese patent medicine for clinical application. Therefore, bezoar is an important raw material drug in my country's p...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P25/20A61P25/00A61P29/00A61K38/01A61K35/413A61K31/409A61K31/575A61K31/685A61K33/30
Inventor 石朝周
Owner 石朝周
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