Small molecule metabolite map for identifying liver cancer, hepatitis or liver cirrhosis and manufacturing method thereof

A technology of small molecule metabolites and metabolites, which is applied in the field of hepatitis or liver cirrhosis small molecule metabolite map and its production, and the identification of liver cancer, which can solve the problems of early diagnosis of liver cancer that cannot be solved
CN102445512AInactive Publication Date: 2012-05-09SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2012-05-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of medical diagnostics, in particular to a small molecule metabolite map for identifying liver cancer, hepatitis or liver cirrhosis and a manufacturing method thereof. The small molecule metabolites are four blood metabolites markers, i.e. palmitoyl hemolysis phosphoric acid ethanolamine glyceride, docosapentaenoic acyl hemolysis phosphatidyl choline, docosahexaenoic acyl hemolysis phosphatidyl choline and taurocholic acid, which respectively have the molecular weight of 453.2855, 569.3481, 567.3319 and 516.2916, and the corresponding ions of 454.2928, 570.3547, 568.3391 and 480.2776 detected through mass spectrum. Through experimentation on animals, the accuracy for determination of the liver cancer phase of a rat is 85 percent, and the accuracy for determination of the hepatitis or the liver cirrhosis is 94 percent. Clinical experiment results show that the accuracy for determination of the liver cancer is 85 percent, and the accuracy for determination of non-liver cancer is 71.9 percent. The method provided by the invention has the advantages of high sensitivity and high throughput, is superior to the existing liver cancer single diagnosis marker, and is applicable to screening and assisted diagnosis of the liver cancer.
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Description

technical field

[0001] The invention relates to the technical field of medical diagnostics, and relates to a small blood molecule metabolite map for identifying liver cancer, hepatitis or cirrhosis and a preparation method thereof. Background technique

[0002] As an important technical means in the field of systems biology in the post-genome era, metabolomics has made great progress in recent years. Metabolomics focuses on the dynamic changes of all metabolites in cells, tissues, and organs after pathological stimulation or genetic modification, and systematically describes the occurrence and development of diseases through changes in metabolites from an overall perspective. All metabolites in body fluids can be used as indicators of the state of the living system, not only can reflect the results of various physiological adjustments, but also can be developed into a powerful tool for assisting clinical diagnosis. At present, corresponding diagnostic metabolic markers have...

Claims

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