39 results about "Bridging ligand" patented technology

The invention discloses a multi-emission composite nano ratiometric fluorescent probe for detecting fluoroquinolone antibiotics and a preparation method of the multi-emission composite nano ratiometric fluorescent probe. The CdTe-Tb-UMP composite nano ratiometric fluorescent probe with double ligands is prepared by taking metal terbium ions (Tb < 3 + >) as central ions and respectively taking uridine monophosphate (UMP) and CdTe quantum dots with red fluorescence emission as bridged ligands. ENR is further coordinated with Tb < 3 + >, energy is transferred to Tb < 3 + > through an antenna effect, so that characteristic green fluorescence of Tb < 3 + > is turned on, and fluorescence of CdTe quantum dots is almost kept unchanged. On the basis, a portable nursing point testing system is further constructed, and the portable nursing point testing system comprises an intelligent mobile phone detector and a wearable fingertip sensor integrated with a micro-fluidic chip and is used for on-site rapid detection of the ENR. The paper-based chip shows rapid and sensitive fluorescence response, and the detection limits of the spectrograph and the paper-based sensor on the ENR are 4.7 nM and 13.1 nM respectively. The probe can be applied to detection of ENR in actual environment water samples, food and drugs.

The invention relates to the technical field of photoelectrocatalysis, in particular to a Co (II) coordination polymer photoelectrode crystalline material and a preparation method and application thereof. The Co (II) coordination polymer {[Co (H2O) (Br-BDC) (BMIP)]. H2O} n is obtained from organic ligands BMIP, H2 (Br-BDC) and cobalt salt through a solvothermal method, cobalt (II) ions serve as three connection nodes, BMIP and H2 (Br-BDC) ligands serve as bridging ligands to be in mutual bridging, a two-dimensional honeycomb structure is formed, and a three-dimensional supramolecular structure is formed between layers through intermolecular hydrogen-bond interaction and pi-pi stacking. Wherein H2 (Br-BDC) is 2, 5-dibromoterephthalic acid, BMIP is 1, 3-bis (dimethylimidazolyl) propane, and n is a positive integer. The Co (II) coordination polymer shows relatively good photoelectric property, has the potential of serving as a photoelectrode material, has good optical and electrical characteristics, can be used for constructing an efficient photoelectrocatalysis water decomposition system, and has an application prospect in the aspects of photoelectric hydrolysis water oxidation and the like.

The present application relates to a kind of carboxyl functional time-resolved fluorescent microspheres and its preparation method, belong to fluorescent microsphere technical field.The preparation method described in the present application includes the following steps, under acidic conditions, europium salt, lanthanide salt, beta-diketone ligand, synergistic ligand and bridging ligand occur in organic solvent, obtain binuclear rare earth complex;Binuclear rare earth complex, styrene monomer, acrylic monomer, initiator, polyvinylpyrrolidone, emulsifier occur in solvent dispersion polymerization reaction, obtain the carboxyl functional time-resolved fluorescent microsphere.The preparation method described in the present application directly coats dye in the microsphere interior in polymerization stage, need not consider time-resolved fluorescent dye steric effect, can select greater, but fluorescence intensity stronger, cannot be applied to swelling method binuclear rare earth complex as time-resolved fluorescent dye, so that the fluorescence intensity of time-resolved fluorescent microsphere is higher.

The invention discloses a photosensitive nanocrystal material and a preparation method thereof, and belongs to the technical field of photoresist production processes. In order to solve the problems that an existing photoresist material is low in light absorption efficiency, insufficient in resolution ratio and complex in preparation, an Hf / Zr mixed metal alkoxide precursor is adopted, and the photoresist material is prepared through the steps of anhydrous hydrolysis, two-phase reaction, surface modification, photosensitive addition and the like. The method specifically comprises the following steps: (i) dropwise adding ultrapure water at a low temperature to react with a first ligand A to form 1.5-3nm metal oxide nanocrystalline sol; (ii) reacting alkali liquor in the two-phase system to grow crystals; (iii) carrying out surface modification on the bridged ligand B and the second ligand C; and (iv) adding a photoacid generator and a free radical photoinitiator, filtering with a filter membrane, and pre-drying to form the membrane. The material is suitable for a negative photoetching process, and the EUV absorption efficiency is gt; 85%, LWRlt; 2 nm. The method is simple to operate, and the yield is gt; the stability and the resolution ratio of the material are remarkably improved, and the material is suitable for sub-10nm semiconductor photoetching.

This invention discloses a bifunctional fluorescent probe and method for simultaneously detecting hydroxyl radicals and iron ions, belonging to the field of analytical and environmental monitoring. The bifunctional fluorescent probe is prepared by adding a ruthenium complex [Ru(bpy)2(DA-phen)] during the synthesis of MOF-808. 2+ A one-pot method was used to prepare ruthenium complex-encapsulated MOF material, which is the bifunctional fluorescent probe MOF-808@Ru for the simultaneous detection of hydroxyl radicals and iron ions. This invention uses a zirconium oxide cluster as the metal center and trimesic acid as the bridging ligand, simultaneously encapsulating [Ru(bpy)2(DA-phen)]. 2+ A MOF-808@Ru composite fluorescent probe with dual recognition units was prepared. This probe enables in-situ visualization of endogenous ·OH and Fe in biological systems. 3+ In addition, it can also sensitively detect ·OH and Fe in environmental water samples. 3+ Furthermore, by using fluorescence imaging to dynamically reflect changes in Fenton's reagent during simulated wastewater treatment, it has broad application prospects in the field of environmental monitoring.

Metal complexes with nitrile ligands of the type MO2X2L2, where M is molybdenum or tungsten, X is a halogen, each L is independently an organonitrile ligand with the general formula NCR, where each R is independently a C2-C18 group. Metal complexes with dinitrile bidentate ligands of the type MO2X2L′, where L′ is a dintrile ligand, and dinitrile bridging ligands of the type (MO2X2)2L′, where L′ is a dinitrile bridging ligand connecting the two metal atoms. Methods of making and using the metal complexes are described.

The invention relates to the technical field of high polymer materials, and discloses a polymethyl methacrylate composition and a preparation method thereof, and the polymethyl methacrylate composition is prepared from the following raw materials in parts by weight: 100 parts of polymethyl methacrylate resin, 0.2-3.2 parts of a Lewis acid center provider, 0.2-3.2 parts of a multifunctional bridging ligand, and 0.1-1.1 parts of a competitive replacement aid. The preparation method comprises the step of carrying out melt blending on the components. According to the invention, through the synergistic effect of the Lewis acid center provider and the multifunctional bridging ligand, a dynamic reversible supramolecular network is constructed in a polymethyl methacrylate matrix, and the structure of the supramolecular network effectively improves the impact toughness, rigidity and thermal deformation temperature of the material. The technical problem that toughness, rigidity, heat resistance and processability of a traditional polymethyl methacrylate material are difficult to consider at the same time is solved, and the polymethyl methacrylate composition with excellent comprehensive performance is prepared.

The present invention relates to the technical field of fluorescent active substances, and in particular to a zinc (II)-based metal organic framework crystalline material, its preparation method, and application. The molecular formula of the zinc (II)-based metal organic framework crystalline material of the present invention is [Zn(NH2-BDC)2(BMIP)2] n The zinc(II) ion serves as the connecting node, and BMIP and NH2-BDC ligands serve as bridging ligands to form a three-dimensional structure. The asymmetric structural unit of the crystal consists of a BMIP ligand and a deprotonated 2-aminoterephthalic acid ligand. The zinc ion has a four-coordinated, asymmetric tetrahedral configuration. A divalent zinc ion fluorescent sensing material can be prepared using a one-pot solvothermal reaction. The zinc(II) fluorescent sensing material exhibits a strong fluorescence emission spectrum and is suitable for applications in molecular fluorescent probes and metal ion detection.

The invention relates to the technical field of research and development of tumor photodynamic therapy photosensitizers, photothermal therapy photothermal reagents and sonodynamic therapy sonosensitizers, and provides a preparation method and application of a binuclear metal complex of a polythiophene bridging ligand. The invention relates to a ruthenium complex TBLRu3a-TBLRu6a and a ruthenium complex TBLRu3b-TBLRu6b of a polythiophene bridged tri-bidentate ligand, a ruthenium complex TTLRu1-TTLRu12 of a polythiophene bridged bis-tridentate ligand, and an osmium complex TTLOs1-TTLOs6 of a polythiophene bridged bis-tridentate ligand, which are respectively designed and invented by the invention. The invention further relates to a preparation method of the ruthenium complex TBLRu3a-TBLRu6a and the ruthenium complex TBLRu3b-TBLRu6b of the polythiophene bridged tri-bidentate ligand and a preparation method of the ruthenium complex TTLRu1-TTLRu12 of the polythiophene bridged bis-tridentate ligand. The polythiophene bridged metal complex has extremely high stability and excellent two-photon absorption characteristic, has excellent biotoxicity and photothermal conversion capability under the action of infrared exciting light, and can induce A549R cell apoptosis. The polythiophene bridged metal complex provided by the invention is a potential novel two-photon absorption photodynamic therapy photosensitizer, a photothermal therapy photothermal reagent and a sonodynamic therapy sonosensitizer, and has a wide application prospect in photodynamic therapy, photothermal therapy and sonodynamic therapy of tumors.

This application relates to the field of seawater electrolysis technology, and more particularly to a chlorine-resistant MOF anode material for seawater electrolysis and its preparation method. The chlorine-resistant MOF anode material comprises a porous conductive substrate and a metal-organic framework (MOF) catalyst layer grown in situ on the surface of the porous conductive substrate. The MOF catalyst layer includes a transition metal center and a ternary ligand system coordinated to the transition metal center. The ternary ligand system includes 2,5-thiophene dicarboxylic acid as a bridging ligand, and ferrocene carboxylic acid derivatives and pyridine carboxylic acid derivatives as non-bridging ligands. Through the synergistic co-assembly of the ternary ligands, a dense three-dimensional physical protective barrier is constructed on the surface of the catalyst material, enabling the catalyst to exhibit excellent stability in natural seawater media without any desalination or purification pretreatment. This reduces the stringent requirements on the quality of the reaction feed water and eliminates the need for complex seawater desalination pretreatment processes in industrial systems.

The present invention belongs to the technical field of fluorescent active material development, and particularly relates to a cadmium (II)-based metal organic framework crystalline material, its preparation method, and application. The molecular formula of the cadmium (II)-based metal organic framework crystalline material is {[Cd3(Br-BDC)3(BMIP)2]·2H2O} n， The three-dimensional structure is formed using cadmium (II) ions as connecting nodes, BMIP and H2 (Br-BDC) ligands as bridging ligands. The structure contains Cd-O secondary structural units, with three Cd atoms forming a trinuclear Cd-O cluster structure through the Cd-O secondary structural units. The Cd1 and Cd1# atoms exhibit mirror-image symmetry. The present invention utilizes a one-pot solvothermal reaction to prepare a divalent cadmium ion fluorescent sensing material. This preparation method has the advantages of a simple process, easy operation, high yield, and good reproducibility. The cadmium (II) fluorescent sensing material exhibits a strong fluorescence emission spectrum and can be applied in molecular fluorescent probes, metal ion detection, and other fields.

The invention relates to the technical field of photoelectrocatalysis, in particular to a Ni (II)-based coordination polymer photoelectrode crystalline material and a preparation method and application thereof. The Ni (II)-based coordination polymer {[Ni (H2O) (Br-BDC) (BMIP)]. H2O} n is obtained from organic ligands BMIP, H2 (Br-BDC) and nickel salt through a solvothermal method, nickel (II) ions serve as three connection nodes, BMIP and H2 (Br-BDC) ligands serve as bridging ligands to be in mutual bridging, a two-dimensional honeycomb structure is formed, and a three-dimensional supramolecular structure is formed between layers through intermolecular hydrogen-bond interaction and pi-pi stacking. Wherein H2 (Br-BDC) is 2, 5-dibromoterephthalic acid, BMIP is 1, 3-bis (dimethylimidazolyl) propane, and n is a positive integer. The Ni (II)-based coordination polymer shows relatively good photoelectric properties, has the potential of serving as a photoelectrode material, has good optical and electrical characteristics, can be used for constructing an efficient photoelectrocatalysis water decomposition system, and has application prospects in the aspects of photoelectric hydrolysis water oxidation and the like.

The invention discloses a method for preparing an indium oxide powder material, which comprises the following steps: with indium nitrate and 1, 4-naphthalic acid as reaction raw materials, adding a surface modifier accounting for 0-20% of the total mass of the reaction raw materials into an organic solvent system to prepare an indium-based metal organic framework material; separating, washing and drying the indium-based metal organic framework material to obtain an indium-based metal organic framework precursor; and annealing the indium-based metal organic framework precursor to obtain the indium oxide powder material. According to the preparation method, 1, 4-NDC is selected as an organic bridging ligand, the concentration of the 1, 4-NDC and the dosage of a surface modifier are regulated and controlled, an In-MOF structure with a special morphology can be formed through induction, and the morphology can be kept intact through adjustment of the annealing temperature and parameters; the morphology controllability of the indium oxide particles allows crystal face exposure and charge transfer paths of the indium oxide particles to be customized, and the performance of the indium oxide particles in optoelectronic equipment, energy storage and photocatalysis is optimized.

The present application relates to a kind of manganese porphyrin metal organic framework material and its preparation method and application, its preparation method includes the following steps: manganese salt, porphyrin ligand, auxiliary regulator and organic solvent are mixed, solvent thermal reaction is carried out, and manganese porphyrin metal organic framework material is obtained;Auxiliary regulator includes polyvinylpyrrolidone, benzoic acid and pyrazine.The present application is by introducing auxiliary regulator, polyvinylpyrrolidone and pyrazine are the key to ensure yield and participate in framework structure formation, it is as structure directing agent and auxiliary bridging ligand and participates in the formation process of framework structure, any component is missing cannot obtain target manganese porphyrin metal organic framework material;Benzoic acid promotes the formation of coordination bond by adjusting the local acid-base environment of reaction system, is the key to promote manganese ion center coordination;Three synergistically build manganese porphyrin metal organic framework material with high proportion of manganese ion center coordination, effectively promote the use of visible light, and then improve its photocatalytic performance.

The invention discloses a bimetallic heteronuclear complex as well as a preparation method and application thereof, and relates to the technical field of environmental catalytic materials and preparation. The complex is prepared by adopting a two-step method of'pre-complexing first and bridging later ', under the protection of inert gas, two metal precursors and a terminal ligand are respectively subjected to primary coordination and premixing under an acidic condition, then a bridging ligand is added, a bridging reaction is completed in a weak alkaline environment, and a product is obtained through precipitation and drying. And ball-milling and mixing the complex and a carrier, and then carrying out heat treatment to prepare the bimetallic supported catalyst. The catalyst plays a synergistic effect by constructing atomic-scale dispersed bimetallic active sites, shows a wide active temperature window, high activity and selectivity in denitration, N2O decomposition and CO catalytic oxidation reaction, has excellent sulfur resistance and hydrothermal aging resistance, is suitable for various carriers and reactions, is controllable in cost, and provides a new path for purification of atmospheric pollutants.

The present invention discloses a MOF microsphere and a synthesis method thereof, relating to the field of material technology. The preparation method of the present invention comprises the following steps: S1, dissolving an inorganic salt with metal ions and an amino acid regulator in a solvent, and ultrasonically dissolving the mixture to form a uniform and transparent mixed solution; S2, dissolving an organic bridging ligand in a solvent, and ultrasonically dissolving the mixture to form a uniform and transparent solution; S3, pouring the solution obtained in the above step S2 into the solution obtained in step S1, mixing, and hydrothermally synthesizing the MOF microspheres. The MOF microspheres prepared by the present invention are formed by self-assembly and stacking of octahedral MOF units, transforming from a 30-80nm octahedral structure to a 0.5-3μm MOF microsphere. The microsphere material has microporous, mesoporous, and macroporous structures. The method involved in preparing the MOF microspheres of the present invention is simple, the process is safe and controllable, the prepared material has a uniform structure, a large specific surface area, good stability in aqueous and acid-base solutions, and combines the advantages of the microstructure and function of the octahedral MOF unit.

This invention belongs to the field of catalyst preparation and application technology, and discloses a method for preparing sulfur-bridged bimetallic alkyne complexes and their application in the dehydrogenation coupling synthesis of 1,4-diyne. The method uses thiols or thiophenol salts as bridging ligands, with each metal center coordinated with a cyclopentadienyl group or a substituted cyclopentadienyl group. This invention achieves coordination activation of the terminal alkyne by controlling the oxidation state of the metal center and altering the bonding mode of the terminal alkyne at the metal center. In this system, the sulfur-bridged ligand not only assists the metal center in activating the terminal alkyne but also stabilizes a key intermediate in the catalytic process. Subsequently, the coordinated-activated terminal alkyne undergoes a reductive elimination process to generate 1,4-diyne. This reaction can be carried out in a temperature range of -100℃ to 25℃, with a reaction time of 0.5 to 48 hours. This method can synthesize a series of novel sulfur-bridged bimetallic alkyne complexes with high yield and high selectivity, providing a novel catalytic system for the activation of C-H bonds in terminal alkynes mediated by inexpensive metals and the further synthesis of 1,4-diyne.

The invention concerns an insoluble salt composition having antimicrobial activity, said composition containing zinc and a cation of a cationic surface-active agent, wherein the cationic surface-active agent is preferably selected from benzalkonium, didecyldimethylammonium, octenidine and chlorhexidine. The invention further relates to an insoluble compound having antimicrobial activity, said compound having a structure represented by the general formula (W"1+)n[Zn2+(L2-)2], wherein W is a cationic surface active agent, preferably selected from benzalkonium, didecyldimethylammonium, octenidine and chlorhexidine and L is a bridging ligand capable of coordinating the zinc cation and capable of binding through an ionic bond the cation of a cationic surface active agent, preferably selected from the group consisting of 2-mercapto-5-benzimidazole sulfonate and 3-mercapto-1-propansulfonate, and mixtures thereof. The invention further relates to an antimicrobial powder composition or a functionalized antimicrobial powder comprising the insoluble salt composition according to the invention and a silica powder, such as silicon dioxide or silicon dioxide amorphous, wherein the salt composition is adsorbed to the surface of the silica powder. The composition and compound of the invention may be included in alcoholic solutions or may be formulated as gel, cream or powder. The composition and compound of the invention may be used in antimicrobial treatment, antiviral treatment and / or antifungal treatment

The invention belongs to the technical field of preparation of metal complexes, and discloses a sulfur / carbon ligand bridged bimetallic complex, a preparation method thereof and an application of the sulfur / carbon ligand bridged bimetallic complex in dehalogenation conversion of chlorine / brominated alkane into corresponding alkane or olefin, thiophenol is used as a bridged ligand, and each metal center is coordinated with cyclopentadienyl or substituted cyclopentadienyl. And reacting the double halogen atom bridged bimetallic complex with thiophenol dilithium salt to obtain the sulfur / carbon ligand bridged bimetallic complex. The sulfur / carbon ligand bridged bimetallic complex provided by the invention can be used for dehalogenation conversion reaction of chlorine / brominated alkane under specific reaction conditions to obtain corresponding alkane or olefin, the reaction temperature is-78 to 40 DEG C, and the reaction time is 0.5 to 48 hours. According to the method, the reaction conditions are easy to control, the reaction temperature range is wide, the corresponding alkane or olefin and sulfur-bridged bimetallic dihalogen atom complex can be obtained, a new effective way is provided for resource utilization of chloro / brominated alkane, and the method has wide application prospects in the fields of organic synthesis, environmental governance and the like.

The present invention discloses a zinc coordination polymer, a preparation method thereof and an application thereof in detecting ceftazidime. The coordination polymer chemical formula is {[Zn(fipa)(3-bpdb)2} n , where fipa is a completely deprotonated organic bridging ligand 5-(furan-2-yl)isophthalate, 3-bpdb is an auxiliary ligand 1,4-bis(3-pyridyl)-2,3-dichloro-1,3-butadiene, n represents the degree of polymerization, which is a natural number; each four-coordinated metal Zn is at the center of a distorted tetrahedral geometry. 2+ The zinc coordination polymer is linked to two 1,4-bis(3-pyridyl)-2,3-dichloro-1,3-butadiene chains to form a V-shaped structure. This structure is then connected to a long-range, ordered one-dimensional chain structure along the a-axis by a deprotonated 5-(furan-2-yl)isophthalic acid group. Adjacent chains are connected by abundant hydrogen bonds (C−H···O) and π···π stacking interactions to form a three-dimensional supramolecular framework. The zinc coordination polymer can detect ceftazidime in water in a relatively short time, with high sensitivity, strong selectivity, and good thermal and water stability. It has great potential for the detection of ceftazidime antibiotics.

The present invention relates to the field of catalyst technology, and in particular to the preparation of a copper (II) catalyst and its application in catalyzing the synthesis of polyvinyl chloride. The present invention simultaneously coordinates a copper ion with a 1-(3-carboxyphenyl)-5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxyl (3-PDCA) ligand and a 4,4'-bipyridine ligand, and utilizes two bridging ligands to form a special hexagonal network structure, thereby obtaining a copper (II) catalyst with a novel structure. The copper (II) catalyst has high acetylene conversion and good stability. More importantly, the development of a new coordination polymer catalyst makes it possible to replace traditional catalysts, thus filling the industry gap in mercury-free production of polyvinyl chloride using the calcium carbide process.

The invention relates to the technical field of fluorescent active substances, in particular to a zinc (II)-based metal organic framework crystalline material as well as a preparation method and application thereof. The molecular formula of the zinc (II)-based metal organic framework crystalline material is [Zn (NH2-BDC) 2 (BMIP) 2] n, zinc (II) ions serve as connecting nodes, BMIP and NH2-BDC ligands serve as bridging ligands to be in bridge connection, a three-dimensional space structure is formed, an asymmetric structural unit of a crystal comprises a BMIP ligand and a deprotonated 2-amino terephthalic acid ligand, and the molecular formula of the zinc (II)-based metal organic framework crystalline material is as shown in the specification. And the zinc ion is of a four-coordinated asymmetric tetrahedral configuration. The divalent zinc ion fluorescence sensing material can be prepared by adopting a one-pot solvothermal reaction, and the zinc (II) fluorescence sensing material is relatively high in fluorescence emission spectrum intensity and can be applied to the fields of molecular fluorescence probes, metal ion detection and the like.

The present application discloses an organometallic compound for extreme ultraviolet (EUV) lithography, a composition, and a dry photoresist or hard mask. The organometallic compound contains at least one bismuth element selected from the group consisting of Bi (III) and Bi (V). The organometallic compound also comprises at least one C1 to C6 alkyl ligand bonded to the bismuth element and at least one terminal or bridging ligand A (O, S or N-R, where the R group in N-R is H or C1 to C6 alkyl). Methods of making the dry photoresist or hardmask compositions and methods of using the compositions to form patterned material features on a substrate are also disclosed.

This invention discloses a method for preparing a tetranuclear supramolecular macrocycle containing a semi-sandwich ruthenium structure and its application in antibacterial applications, belonging to the field of antibacterial pharmaceutical technology. The method for preparing the tetranuclear supramolecular macrocycle includes: mixing silver trifluoromethanesulfonate with a methanol solution, filtering, adding two ligands and NaOH to the filtrate, and purifying to obtain the complex. The tetranuclear ruthenium supramolecular macrocyclic complex of this invention contains multiple positively charged ruthenium centers in its molecule, exhibiting a stronger multivalent effect, thereby effectively penetrating into the bacterial cell membrane and leading to bacterial death; it can form a novel antibacterial agent with low toxicity and excellent anti-biofilm activity; it solves the problems in existing technologies where the metal centers are mostly relatively highly toxic Pt(II) and Cu(II), and the rigid bridging ligands used lack biomimetic recognition ability with key bacterial biomolecules, limiting their antibacterial ability and selectivity.

This invention discloses a photosensitive nanocrystalline material and its preparation method, belonging to the field of photoresist manufacturing technology. To address the problems of low light absorption efficiency, insufficient resolution, and complex preparation of existing photoresist materials, this invention uses an Hf / Zr mixed metal alkoxide precursor and prepares it through steps including anhydrous hydrolysis, two-phase reaction, surface modification, and photosensitive addition. Specifically, it includes: (i) reacting ultrapure water with the first ligand A at low temperature to form a 1.5-3 nm metal oxide nanocrystalline sol; (ii) growing crystals through an alkaline reaction in the two-phase system; (iii) surface modification with bridging ligand B and the second ligand C; and (iv) adding a photoacid generator and a free radical photoinitiator, filtering with a filter membrane, and pre-baking to form a film. This material is suitable for negative lithography processes, with an EUV absorption efficiency >85% and an LWR <2 nm. The method of this invention is simple to operate, has a yield >85%, significantly improves material stability and resolution, and is suitable for sub-10 nm semiconductor lithography.

The present application relates to the development of a photosensitizer for photodynamic therapy of tumors, a sonosensitizer for sonodynamic therapy, and a photothermal reagent for photothermal therapy, and provides a bithiophene-benzene bridged ligand and a preparation method thereof, and a bithiophene-benzene bridged dinuclear metal complex and a preparation method and application thereof. The present application is based on a bithiophene-benzene bridged ligand dtdpip, and a bithiophene-benzene bridged dinuclear ruthenium complex, a bithiophene-benzene bridged dinuclear osmium complex and a bithiophene-benzene bridged dinuclear iridium complex are respectively designed and invented. The bithiophene-benzene bridged dinuclear metal complex has extremely high stability and excellent two-photon absorption characteristics, and has excellent biological toxicity and photothermal conversion capacity under the action of infrared excitation light and ultrasonic waves. The conjugated bithiophene dinuclear metal complex provided by the present application is a potential new type of infrared photodynamic photosensitizer, sonosensitizer and photothermal reagent, and has a broad application prospect in the photodynamic therapy, sonodynamic therapy and photothermal therapy of tumors.

This invention discloses a photo-switching organoiridium metal complex, its preparation method, and its applications, belonging to the field of photoisomerization materials technology. This invention involves forming an N^N ligand through a Sonogashira coupling reaction between alkynyl spiropyran and phenanthroline, and finally coordinating with a bridging ligand to form a photo-switching organoiridium metal complex. This photo-switching iridium metal material combines nonlinear optical materials with photoisomerizing spiropyran molecules, exhibiting excellent optical limiting performance, good photothermal stability, photoisomerization characteristics, fatigue resistance, bleaching resistance, and excellent laser protection performance. Furthermore, after ultraviolet irradiation, the expansion of the complex's conjugation degree due to the ring-opening of the spiropyran molecule further enhances its laser protection performance.

The present invention provides a heteronuclear bimetallic Pd-Pt dimer, a preparation method and application thereof, and an organic light-emitting diode, and relates to the technical field of optoelectronic materials. The heteronuclear bimetallic Pd-Pt dimer provided by the present invention shortens the metal-metal distance due to the connecting effect of the bridging ligand, and the luminescence of the heteronuclear bimetallic Pd-Pt dimer is red-shifted. The participation of heavy metal atoms Pd and Pt allows strong spin-orbit coupling to allow effective intersystem crossing between singlet and triplet states, which leads to a high quantum yield of triplet emission. And because the presence of strong field rigid ligands helps to suppress non-radiative decay pathways, high-efficiency luminescence is generated, and the thermodynamic stability is strong. The heteronuclear bimetallic Pd-Pt dimer provided by the present invention is thermodynamically stable, has a high red light quantum yield, high luminescence efficiency, and a long luminescence lifetime, and has good potential application value in organic light-emitting diodes as a phosphorescent luminescent material.

The invention discloses application of cyano-bridged bimetallic nano-enzyme in preparation of a tumor catalytic treatment medicine, and belongs to the technical field of medicines. The invention provides a design strategy of a bimetallic nano-enzyme taking coordination field engineering as a theoretical basis and cyano bridging as a structural carrier, and Cu2 [Fe (CN) 6] is adopted to prepare a tumor catalytic treatment drug. In the nano enzyme, the cyano group is used as a strong field bridging ligand and can form an electron delocalization network, and meanwhile, due to different electronegativity of copper and iron, the d orbital energy levels of copper and iron can generate synergistic distortion, so that electron transfer is synergistically driven, and the electron transfer efficiency is remarkably improved. In addition, by virtue of a cyano bridging effect, the stabilization effect of a strong coordination field can inhibit metal agglomeration, so that Cu is in monatomic distribution, and the catalytic treatment capability of the nano-enzyme is further enhanced. After being modified by an immunogenic tumor exosome, the nano-enzyme not only improves the targeting property to tumors, but also can exert high-efficiency peroxidase-like and glutathione-like oxidase activity in a tumor microenvironment, so that catalysis-immune synergistic treatment is realized.

The invention discloses a tetraphenylethylene-based molecular cage as well as a preparation method and application thereof, 3, 5-TPE is taken as a carboxylic acid bridging ligand, and is subjected to self-assembly reaction with Co < 2 + > and sulfone bridged calixarene [4] to obtain a coordination molecular cage (CoTPE) with a plurality of cavities. The molecular cage provided by the invention has a specific cavity and skeleton structure, a constructed coordination molecule container is used as a carrier, biomedical applications such as loading of drug molecules and pH responsive release can be realized, and in-vivo and in-vitro experiments prove that the molecular cage has a better tumor inhibition effect compared with free sorafenib.