54results about "Thiazine dyes" patented technology

This disclosure provides compositions of electrochromic dyes, functionalized electrochromic dyes and dye macromers which may be incorporated into electrochromic devices with tailored optical properties. The disclosure provides an electrochromic dye with an attached functionalization group wherein the said dye colors by at least one of oxidation and reduction and contains at least two moieties wherein a first moiety is electrochromic and a second moiety is an electrochromic moiety, an electron donating moiety, or an electron receiving moiety and wherein the functionalization group. This disclosure also provides EC compositions and devices for controlling color.

The present disclosure provides a method for producing 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride of formula (I). TIFF2023515614000014.tif3652 The method includes preparing a wet crude 3,7-dibromophenothiazin-5-ium bromide (III) from phenothiazine (II) together with a promoter, a catalyst, and a brominating agent in the presence of an organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis(dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide; and then 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide. The method involves purifying 3,7-bis-(dimethylamino)-phenothiazine-5-ium chloride (I) and removing metal components from the chloride (I) using a metal scavenger. This method eliminates the additional step of an ion exchange column in the reaction and provides a product purity of 99-99.5%.

The present invention describes synthesis of Toluidine blue O for a formulation to be used for screening and biopsy site identification in oral cancer. The invention discloses two formulations and a m

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

The present invention belongs to the technical field of organic synthesis. Provided are a rhodamine-methylene blue derivative fluorescent probe (I), and a preparation method therefor and the use thereof. In the preparation method for the fluorescent probe, raw materials are easily available, and a synthesis method is simple and convenient. The fluorescent probe can achieve synchronous double-channel fluorescence recognition of intracellular ClO- and ATP, and has a detection limit regarding ClO- of 0.90 nM and a detection limit regarding ATP of 23.60 nM; therefore, the fluorescent probe can be used for fluorescence quantitative detection of ClO- and ATP, can also be used in synchronous fluorescence imaging of ClO- and ATP in cells under the stimulation of a drug, and has a wide potential application value.

A purification method for an electron mediator on a biosensor, the electron mediator having an amino. The purification method comprises the following steps: weighing an electron mediator with low purity; reacting an amino protection reagent with the electron mediator to obtain an amino-protected electron mediator, dissolving the amino-protected electron mediator in an organic solvent, and carrying out extraction to obtain an amino-protected electron mediator with high purity; and reacting the amino-protected electron mediator with high purity with a deprotection reagent for amino deprotection, thus obtaining an electron mediator with high purity. The method for purification achieves a very large treatment capacity in one time, effectively improves the purification efficiency of the electron mediator, and reduces the preparation cost. The electron mediator with high purity obtained from purification, serving as one of the components in the reagent on a biosensor, can be used for preparation of biosensors such as a blood glucose test biosensor.

Disclosed are methods of synthesis and / or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

The present invention describes synthesis of Toluidine blue O for a formulation to be used for screening and biopsy site identification in oral cancer. The invention discloses two formulations and a method of delivery of the said formulations via a kit. The method described is a reproducible method of synthesis of pharmaceutical grade Toluidine blue O of acceptable purity and good colorimetric value. The present invention also discloses a kit that includes one formulation of a cleaning solution containing an organic acid and another formulation that is a vital stain formulation. The kit is packaged as a dual chamber sprayer having two pump dispensers, that facilitates ready to use, convenient dental chair side delivery, and allows mass screening.

The present application provides method for producing methylene blue that includes the steps of providing a reaction mixture having one or more methylene blue intermediates; precipitating metal from the reaction mixture; and producing therefrom crude methylene blue. The crude may further be purified, resulting in methylene compounds having low impurities, preferably having a purity greater than about 97%, having Azure B impurity no greater than 2.5%, and / or a total metal content no greater than 77 ppm. Formulations containing such compounds are also provided.

Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula:wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4 alkyl; C2-4 alkenyl; and halogenated C1-4 alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

To inhibit photodegradation of organic compounds.SOLUTION: Provided is a composition comprising a cerium (III) carbonate and a UV-protecting agent.SELECTED DRAWING: None

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

The invention discloses a novel ring-substituted and side-chain amino-substituted nile blue dye and a synthesis method and application thereof, a series of dyes which can be simultaneously used for bacterial fluorescence imaging and photodynamic antibacterial treatment are designed and synthesized by taking the nile blue dye as a parent, and the structure of the novel ring-substituted and side-chain amino-substituted nile blue dye is as shown in a general formula I, the dye has high molar extinction coefficient, fluorescence imaging efficiency and active oxygen generation efficiency, and MNBS-C2-NH2 and MNBS-C6-NH2 synthesized in the embodiment show excellent absorption and fluorescence properties in PBS (Phosphate Buffer Solution) and dichloromethane, especially in a range of 640-660nm. A test result shows that the dyes have a remarkable killing effect on escherichia coli under an illumination condition, log CFU is obviously reduced, and dark toxicity is relatively low. Scanning electron microscope observation further proves that the bacteria subjected to light treatment have obvious membrane surface collapse and rupture phenomena. Through the outer membrane protein of the gram-negative bacteria, the enhanced penetrating ability and killing ability on the gram-negative bacteria can be realized, and wide application prospects are realized in the field of antibacterial treatment.

Provided are tissue regeneration wound treatments, methods of producing the tissue regeneration wound treatments, and methods of treating wounds using the tissue regeneration wound treatments. The tissue regeneration wound treatments include a skin substitute and a colorant applied to the skin substitute. The colorant is a biocompatible colorant that degrades upon attack by proteases within the treated wound.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and / or hosts of formulawhich have a sufficiently small energy gap between S1 and T1 (ΔEST) to enable up-conversion of the triplet exciton from T1 to S1. The organic light emitting elements show high electroluminescent efficiency.

The present invention discloses phenothiazine / phenoxazine-based organic compounds, their preparation methods, and applications. The phenothiazine / phenoxazine-based organic compounds of the present invention have good photophysical properties, high biocompatibility, small molecular weight, large Stokes shift, and excellent targeting performance. They can accurately stain subcellular structures in biological cells and effectively locate them in organelles in a wash-free manner, thereby achieving subcellular structure images with a high signal-to-noise ratio. The phenothiazine / phenoxazine-based organic compounds of the present invention have low cytotoxicity and large Stokes shift as small molecule fluorescent dyes. Compared with commercial organelle dyes, the fluorescent dyes of the present invention can specifically accumulate in cell mitochondria, cell membranes, lysosomes, endoplasmic reticulum, and lipid particles, and have excellent photostability, and can be used to observe the microstructure of cells and cell-to-cell interactions for a long time.

The invention discloses a dichroic dye, a liquid crystal composition and application of the dichroic dye. The structural general formula of the disclosed dichroism dye compound is shown as I in the specification. The liquid crystal composition comprises the dichroic dye and at least one liquid crystal compound. The dimming glass device prepared from the dichroic dye or the liquid crystal composition has the advantages of high photo-thermal stability, high order parameter and wide working temperature range.

The invention provides a fluorescent dye and a preparation method and application thereof, the fluorescent dye has the following chemical structural formula: wherein R1 and R2 are respectively and independently selected from H, Cl, Br and I; r3 is selected from alkyl, and n is a positive integer. The problems that a traditional dye is low in binding selectivity and overlapped in life fingerprints in a complex lipid system are solved, and high-resolution recognition of lipid types such as CE, TG and PL in a serum environment is achieved. Meanwhile, extraction-free in-situ classification detection can be carried out on the lipid, when the fluorescent dye is used for the probe, dependence of chromatography and mass spectrometry technologies on tedious pretreatment can be broken through based on the synergistic effect of the fluorescent probe and the fluorescence lifetime imaging technology, and serum lipid spatial distribution analysis and relative quantification of components are achieved. In addition, a standardized classification criterion can be established, and a quantifiable lipid subtype analysis tool is provided for clinic.

The present invention provides a redox polymer for forming an electrochemical sensor that is suitable for use in measurement over a long period (continuous monitoring) and excellent in stability, or a redox mediator constituting the same. The redox mediator provided by the present invention is a phenothiazine-based compound having a hydrophilic moiety introduced therein, the compound being represented by the general formula (2A) or (2B). The redox polymer provided by the present invention is a phenothiazine-based compound bound to a polymer, the compound being represented by the general formula (3A) or (3B). In the formulas, R9 and R10 are both substituents, or one of these moieties is a substituent, and the other moiety is a hydrogen atom, R(L)1, R(L)2, and R(L)4 to R(L)8 are each independently a predetermined group or atom, (QP)1, (QP)2, and (QP)4 to (QP)B are each independently a polymeric structure derived from a high molecular weight polymer which is present when their corresponding R(L)1, R(L)2, and R(L)4 to R(L)8 are a specific group.

A foldable display apparatus and a manufacturing method of an adhesive layer of the same are disclosed. A foldable display apparatus in the embodiments of the present disclosure includes a display panel, a polarizing plate being disposed on the display panel, a cover window being disposed on the polarizing plate, and an adhesive layer being disposed between the polarizing plate and the cover window, wherein the adhesive layer comprises a transparent part being disposed in a position corresponding to a display area of the display panel, and a colored part being disposed in a position corresponding to a non-display area of the display panel.

The present invention relates to a two-component system for mixing photopolymerizable compositions, and elements prepared therefrom, and their use. The photopolymerizable compositions are particularly suitable as recording materials for optical elements with refractive index modulation, in particular holograms.

The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of Formula (2) with an aniline of Formula (3), as described herein. The present invention also relates to such methods which incorporate one or more additional (subsequent and / or preceding) steps, for example, to prepare compounds of Formula (5) from compounds of Formula (1); to prepare compounds of Formula (6) from compounds of Formula (5); and to prepare compounds of Formula (2) from compounds of Formula (4), as described herein.

The invention discloses amino-functionalized Nile blue dye as well as a synthesis method and application thereof, and belongs to the field of organic synthesis. According to the method, by optimizing the catalyst type, the reaction temperature and the solvent system, the generation of isomer byproducts is effectively inhibited, and the reaction selectivity is improved. Compared with the prior art, the synthesis process disclosed by the invention has the advantages of simple reaction steps, mild and controllable conditions, high product yield and high purity; meanwhile, large-scale use of strong acid, strong alkali and expensive noble metal catalysts is avoided, and the production cost is remarkably reduced. The obtained amino-functionalized Nile blue dye has long wavelength absorption, excellent cell membrane permeability and wide pH tolerance range (pH 2-11), and can generate superoxide anion free radicals under red light excitation. Based on the characteristics, the compound can be widely applied to the fields of biological fluorescence labeling and functional material preparation.

The disclosure provides, inter alia, formulations comprising cerium (III) carbonate, and processes for producing cerium (III) carbonate. In embodiments, the disclosure provides methods for passivating photodegradation of organic compounds using cerium (III) carbonate.

A purification method for an electron mediator on a biosensor, the electron mediator having an amino. The purification method comprises the following steps: weighing an electron mediator with low purity; reacting an amino protection reagent with the electron mediator to obtain an amino-protected electron mediator, dissolving the amino-protected electron mediator in an organic solvent, and carrying out extraction to obtain an amino-protected electron mediator with high purity; and reacting the amino-protected electron mediator with high purity with a deprotection reagent for amino deprotection, thus obtaining an electron mediator with high purity. The method for purification achieves a very large treatment capacity in one time, effectively improves the purification efficiency of the electron mediator, and reduces the preparation cost. The electron mediator with high purity obtained from purification, serving as one of the components in the reagent on a biosensor, can be used for preparation of biosensors such as a blood glucose test biosensor.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

The present invention provides a redox polymer for forming an electrochemical sensor that is suitable for use in measurement over a long period (continuous monitoring) and excellent in stability, or a redox mediator constituting the same. The redox mediator provided by the present invention is a phenothiazine-based compound having a hydrophilic moiety introduced therein, the compound being represented by the general formula (2A) or (2B). The redox polymer provided by the present invention is a phenothiazine-based compound bound to a polymer, the compound being represented by the general formula (3A) or (3B). In the formulas, R9 and R10 are both substituents, or one of these moieties is a substituent, and the other moiety is a hydrogen atom, R(L)1, R(L)2, and R(L)4 to R(L)8 are each independently a predetermined group or atom, (QP)1, (QP)2, and (QP)4 to (QP)B are each independently a polymeric structure derived from a high molecular weight polymer which is present when their corresponding R(L)1, R(L)2, and R(L)4 to R(L)8 are a specific group.