24results about "Thiazine dyes" patented technology

This disclosure provides compositions of electrochromic dyes, functionalized electrochromic dyes and dye macromers which may be incorporated into electrochromic devices with tailored optical properties. The disclosure provides an electrochromic dye with an attached functionalization group wherein the said dye colors by at least one of oxidation and reduction and contains at least two moieties wherein a first moiety is electrochromic and a second moiety is an electrochromic moiety, an electron donating moiety, or an electron receiving moiety and wherein the functionalization group. This disclosure also provides EC compositions and devices for controlling color.

The present disclosure provides a method for producing 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride of formula (I). TIFF2023515614000014.tif3652 The method includes preparing a wet crude 3,7-dibromophenothiazin-5-ium bromide (III) from phenothiazine (II) together with a promoter, a catalyst, and a brominating agent in the presence of an organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis(dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide; and then 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide. The method involves purifying 3,7-bis-(dimethylamino)-phenothiazine-5-ium chloride (I) and removing metal components from the chloride (I) using a metal scavenger. This method eliminates the additional step of an ion exchange column in the reaction and provides a product purity of 99-99.5%.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and / or hosts of formulawhich have a sufficiently small energy gap between S1 and T1 (ΔEST) to enable up-conversion of the triplet exciton from T1 to S1. The organic light emitting elements show high electroluminescent efficiency.

The invention discloses a dichroic dye, a liquid crystal composition and application of the dichroic dye. The structural general formula of the disclosed dichroism dye compound is shown as I in the specification. The liquid crystal composition comprises the dichroic dye and at least one liquid crystal compound. The dimming glass device prepared from the dichroic dye or the liquid crystal composition has the advantages of high photo-thermal stability, high order parameter and wide working temperature range.

The invention provides a fluorescent dye and a preparation method and application thereof, the fluorescent dye has the following chemical structural formula: wherein R1 and R2 are respectively and independently selected from H, Cl, Br and I; r3 is selected from alkyl, and n is a positive integer. The problems that a traditional dye is low in binding selectivity and overlapped in life fingerprints in a complex lipid system are solved, and high-resolution recognition of lipid types such as CE, TG and PL in a serum environment is achieved. Meanwhile, extraction-free in-situ classification detection can be carried out on the lipid, when the fluorescent dye is used for the probe, dependence of chromatography and mass spectrometry technologies on tedious pretreatment can be broken through based on the synergistic effect of the fluorescent probe and the fluorescence lifetime imaging technology, and serum lipid spatial distribution analysis and relative quantification of components are achieved. In addition, a standardized classification criterion can be established, and a quantifiable lipid subtype analysis tool is provided for clinic.

A foldable display apparatus and a manufacturing method of an adhesive layer of the same are disclosed. A foldable display apparatus in the embodiments of the present disclosure includes a display panel, a polarizing plate being disposed on the display panel, a cover window being disposed on the polarizing plate, and an adhesive layer being disposed between the polarizing plate and the cover window, wherein the adhesive layer comprises a transparent part being disposed in a position corresponding to a display area of the display panel, and a colored part being disposed in a position corresponding to a non-display area of the display panel.

The invention discloses amino-functionalized Nile blue dye as well as a synthesis method and application thereof, and belongs to the field of organic synthesis. According to the method, by optimizing the catalyst type, the reaction temperature and the solvent system, the generation of isomer byproducts is effectively inhibited, and the reaction selectivity is improved. Compared with the prior art, the synthesis process disclosed by the invention has the advantages of simple reaction steps, mild and controllable conditions, high product yield and high purity; meanwhile, large-scale use of strong acid, strong alkali and expensive noble metal catalysts is avoided, and the production cost is remarkably reduced. The obtained amino-functionalized Nile blue dye has long wavelength absorption, excellent cell membrane permeability and wide pH tolerance range (pH 2-11), and can generate superoxide anion free radicals under red light excitation. Based on the characteristics, the compound can be widely applied to the fields of biological fluorescence labeling and functional material preparation.

A purification method for an electron mediator on a biosensor, the electron mediator having an amino. The purification method comprises the following steps: weighing an electron mediator with low purity; reacting an amino protection reagent with the electron mediator to obtain an amino-protected electron mediator, dissolving the amino-protected electron mediator in an organic solvent, and carrying out extraction to obtain an amino-protected electron mediator with high purity; and reacting the amino-protected electron mediator with high purity with a deprotection reagent for amino deprotection, thus obtaining an electron mediator with high purity. The method for purification achieves a very large treatment capacity in one time, effectively improves the purification efficiency of the electron mediator, and reduces the preparation cost. The electron mediator with high purity obtained from purification, serving as one of the components in the reagent on a biosensor, can be used for preparation of biosensors such as a blood glucose test biosensor.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

The present invention provides a redox polymer for forming an electrochemical sensor that is suitable for use in measurement over a long period (continuous monitoring) and excellent in stability, or a redox mediator constituting the same. The redox mediator provided by the present invention is a phenothiazine-based compound having a hydrophilic moiety introduced therein, the compound being represented by the general formula (2A) or (2B). The redox polymer provided by the present invention is a phenothiazine-based compound bound to a polymer, the compound being represented by the general formula (3A) or (3B). In the formulas, R9 and R10 are both substituents, or one of these moieties is a substituent, and the other moiety is a hydrogen atom, R(L)1, R(L)2, and R(L)4 to R(L)8 are each independently a predetermined group or atom, (QP)1, (QP)2, and (QP)4 to (QP)B are each independently a polymeric structure derived from a high molecular weight polymer which is present when their corresponding R(L)1, R(L)2, and R(L)4 to R(L)8 are a specific group.

A composition of tin-doped titanium dioxide (Sn—TiO2) particles, a redox-active dye that changes color from exposure to ultraviolet (UV) light, visible light, or a combination thereof, and a paint matrix, along with methods of making the composition and uses of the composition are described herein. Compositions of TiO2 particles, wherein the TiO2 particles are at least 80% anatase or at least 80% rutile, in combination with a redox-active dye that changes color from exposure to ultraviolet (UV) light, visible light, or a combination thereof, and a paint matrix are also described herein.

The present invention discloses a Nile blue-PARP inhibitor dye, a synthesis method, and an application thereof. A photosensitizer dye that can be used for both cell imaging and photodynamic therapy is designed and synthesized using Nile blue dye as a matrix. This type of dye retains the high molar extinction coefficient, fluorescence imaging, and reactive oxygen species generation efficiency of Nile blue dye, can effectively improve the killing ability against breast cancer cells, especially BRCA-mutated breast cancer cells, and has a higher lethality. At the same time, it reduces the dark toxicity of the photosensitizer in normal cells and induces ferroptosis in breast cancer cells, thereby achieving extensive killing of breast cancer. The dye has broad application prospects in the treatment of breast cancer.

The invention discloses a dichroic dye, a liquid crystal composition and application of the dichroic dye. The structural general formula of the disclosed dichroic dye compound is shown as I, and the disclosed liquid crystal composition comprises the dichroic dye and at least one liquid crystal compound. The dimming glass device prepared from the liquid crystal composition related to the dichroism dye has the advantages of high light and heat stability, high order parameter and wide working temperature area.

Provided is a photosensitive composition that can achieve suppression of decoloring of a sensitizing dye during unexposed storage.A photosensitive composition contains a polymerizable compound, an electron-donating initiator, a dye whose decoloring reaction is promoted in the presence of an epoxy group, and a cationic polymerizable compound having at least one structure selected from the group consisting of a cyclic ester structure and a 3-membered ring ether structure adjacent to a cyclic aliphatic skeleton in a molecule.

The application provides a fluorescent dye and a preparation method and application thereof, and the fluorescent dye has the following chemical structural formula: wherein R1 and R2 are independently selected from H, Cl, Br and I; R3 is selected from alkyl,, and wherein n is a positive integer. The problems of low binding selectivity and overlapping of life fingerprints of traditional dyes in a complex lipid system are solved, and high-resolution identification of lipids such as CE, TG and PL in a serum environment is realized. Meanwhile, the lipids can be classified and detected in situ without extraction, and when the fluorescent dye is used as a probe, the dependence on chromatography and mass spectrometry technology for complicated pretreatment can be broken based on the synergistic effect of the fluorescent probe and the fluorescent lifetime imaging technology, so that the spatial distribution analysis and relative quantification of serum lipids are realized. In addition, a standardized classification criterion can be established, and a quantifiable lipid subtype analysis tool is provided for clinical use.

Described are methods of preparing reduced 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of formula:wherein: R1 and R9 are independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These methods are particularly useful for producing stable reduced forms, and with high purity. The stability and purity are especially relevant for pharmaceutical compositions for the treatment of disease. The compounds are useful for treatment of e.g. tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs.

The application relates to an electronic device comprising an anode, a cathode, at least one emitting layer between the anode and the cathode, at least one p-doped layer A containing a mono-triarylamine as a host, and at least one layer B containing a mono-triarylamine. The invention further relates to a p-doped mixture comprising a mono-triarylamine of formula (II), (III) or (IV) as a host and an electron acceptor compound as a dopant, and the use of the mixture in an electronic device.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have narrow wavelengths and are suitable for multiplexing. Also disclosed are methods for labeling one or more targets in a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

The invention relates to a compound, to a rubber mixture containing the compound, to a vehicle tire comprising the rubber mixture in at least one component, to a process for producing the compound and to the use of the compound as an aging stabilizer and / or antioxidant and / or antiozonant and / or dye.The compound according to the invention has the formula I).

This invention belongs to the field of new materials and discloses a water-soluble nuclear targeting probe with a V-shaped structure and red fluorescence, as well as its applications. This probe is an aggregation-induced emission fluorescent probe material with both lipophilic and hydrophilic properties, possessing a general structural formula as shown in formula (I) or (II), where M is a hydrophobic aromatic ring and A is a hydrophilic nitrogen heterocyclic cation. Due to its unique structure, the aggregation-induced emission fluorescent probe material of this invention exhibits amphiphilicity and better universality for the physiological environment of cells. This probe can individually target and stain the cell nucleus without background fluorescence, enabling wash-free imaging.

Provided herein is a process for preparation of 3,7-bis-(dimethy-lamino)-phenothiazin-5-ium chloride: Formula (I). The said process comprises preparing 3,7-dibromophenothiazin-5-iumbromide wet Crude(III) from phenothiazine (II) alongpro-moter, catalyst and brominating agent in presence of organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide and subsequently purifying and removing metal content through metal scavenger from 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (I). The present process eliminates the additional step of ion exchange column in the reaction and provides 99 to 99.5 percentage of product purity.

Provided are tissue regeneration wound treatments, methods of producing the tissue regeneration wound treatments, and methods of treating wounds using the tissue regeneration wound treatments. The tissue regeneration wound treatments include a skin substitute and a colorant applied to the skin substitute. The colorant is a biocompatible colorant that degrades upon attack by proteases within the treated wound.