40 results about "Thiosulfonic Acids" patented technology

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-rho-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O.A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.

The invention discloses a pesticide composition containing a thiosulfonic acid ester fungicide. The pesticide composition contains 10-60% of thiosulfonic acid ester, powders of 1-40 parts of methoxy-crylic acid fungicide, a soluble concentrate, a microemulsion, an emulsion in water, a suspending agent or missible oil. The pesticide composition is a compound composition of the thiosulfonic acid ester fungicide and the methoxy-crylic acid fungicide, high synergetic effect can be generated, and the capabilities of sterilization, disease prevention and healing can be reinforced, so that the crop can be prevented from falling ill in the growth process, and the yield and the quality are improved; the pesticide composition has a broad-spectrum sterilization capability, can prevent the diseases caused by various germs, and particularly plays the role of forcefully killing the moulds; and according to the pesticide composition, the use dose is reduced relatively, and the using cost is lowered relatively; the pesticide composition is processed to be a water-based environment-friendly agent, such as the emulsion in water, the microemulsion, a suspending agent and a suspension emulsion, the use dosage of the organic solvent is reduced, and the safety of the pesticide composition is improved.

Provided is an inkjet recording medium in which hydrated alumina and a sulfinic acid compound or thiosulfonic acid compound coexist in a pigment in an ink receiving layer, and which can prevent white-background yellowing during storage in a resin file holder or the like and ensure printing quality at the same time. The ink receiving layer of the inkjet recording medium contains the sulfinic acid compound or thiosulfonic acid compound, which functions to prevent yellowing, in a salt form or in a free form so as to be diffusible.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of a thiosulfonate compound. The invention provides the synthesis method of the thiosulfonate compound. The method comprises the following steps that methanesulfonohydrazide compounds, thiophenol compounds, oxidizing agents and catalysts are dissolved into a solvent for reaction; purification isperformed to obtain the thiosulfonate compound; oxidizing agents are any one kind or several kinds of materials from tertiary butanol peroxide and catalysts are sodium iodide, potassium iodide, ammonium iodide, iodine element and tetrabutylammonium iodide. Through experiment testing, the thiosulfonate compound prepared by the technical scheme provided by the invention has the advantages that no side reaction occurs; the yield can reach 84 to 100 percent; the conversion rate is high; meanwhile, the used catalysts and catalysts are environment-friendly compounds; the environment pollution cannot be caused; the reaction temperature is low; the method is suitable for industrial mass popularization. The defects that in the prior art, the damage to the environment in the asymmetric thiosulfonates synthesis process is great, and the application to industrial production cannot be realized are overcome.

The invention discloses a preparation method of methylene blue, and belongs to the technical field of intermediate synthesis in fine chemical engineering. The preparation method comprises the following steps: in a condensed hydrochloric acid solution, carrying out nitrosation reactions between sodium nitrite and N,N-dimethylaniline so as to obtain an intermediate namely p-nitroso-N,N-dimethylaniline; subjecting p-nitroso-N,N-dimethylaniline to hydrogenation reduction to prepare p-amino-N,N-dimethylaniline; oxidizing p-amino-N,N-dimethylaniline, then adding sodium thiosulfate to carry out addition reactions to prepare 2-amino-5-dimethylaminophenyl thiosulfonic acid, adding N,N-dimethylaniline into 2-amino-5-dimethylaminophenyl thiosulfonic acid to carry out oxidative condensation reactions to generate bis(4-dimethylaminophenyl) thiosulfonic acid; and making bis(4-dimethylaminophenyl) thiosulfonic acid carry out ring-closing reactions to obtain methylene blue. The provided preparation method has the advantages of high product purity, simple technology flow, low manufacture cost, suitability for industrial production, easily-available raw materials, and little pollution to the environment.

The invention discloses an abalone blood cell anticoagulant protective agent and a preparation method thereof, and relates to an anticoagulant protective agent. The invention provides an abalone blood cell anticoagulant protective agent for maintaining the activity of isolated abalone blood cells within longer time and a preparation method thereof. The abalone blood cell anticoagulant protective agent comprises the following raw materials by mass percentage: 1.95 to 2.08 percent of glucose, 0.78 to 0.8 percent of sodium citrate (2H2O), 0.063 to 0.107 percent of citric acid, 0.37 to 0.57 percent of sodium chloride, 0.21 to 0.24 percent of hydroxyethyl piperazinyl ethyl thiosulfonic acid, and 100 percent of double distilled water, wherein the pH value is between 6.0 and 6.4. The abalone blood cell anticoagulant protective agent is obtained by dissolving the glucose, the sodium citrate (2H2O), the sodium chloride and the hydroxyethyl piperazinyl ethyl thiosulfonic acid into the double distilled water, stirring and dissolving the mixture, using the citric acid to adjust the pH value to be between 6.0 and 6.4, and performing high-temperature sterilization.

PCT No. PCT/RU97/00338 Sec. 371 Date Apr. 28, 1999 Sec. 102(e) Date Apr. 28, 1999 PCT Filed Oct. 28, 1997 PCT Pub. No. WO98/18758 PCT Pub. Date May 7, 1998Sodium salt of (poly-(2,5-dihydroxy-phenylene))-4-thiosulfonic acid, being a cyclo-linear polymer, is proposed as the regulator of a cell metabolism. There are provided for the production of the claimed preparation: interaction of para-benzoquinone and sodium thiosulfate at the molar ratio of 10:1 to 2:1, separation of a final product, and purification from admixtures. The interaction of para-bernzoquinone and sodium thiosulfate is made in a water-organic medium, preferably in the water-acetone one, at the temperature of 40 to 70 C.

The invention discloses a method for synthesizing a 11-sulfenylnaphtho[2,3-b]benzofuran compound. The method is characterized in that 2-ethyleneoxyphenylacetylene and thiosulfonate are used as substrates, disulfide is used as an additive, Na2-Eosin Y is used as a photosensitizer, and light-irradiation stirring is performed under inert gas and heating conditions to obtain the product 11-sulfenylnaphtho[2,3-b]benzofuran. The method has the advantages of no need for transition metal addition in reactions, simple operation, considerable yield, environmental protection performance and good application prospects.

A pipronil-containing composite pesticide is prepared from the following raw materials, by weight, 6-11 parts of fipronil, 3-8 parts of sodium thiosulfonate, 2-6 parts of turpentine, 1-5 parts of fermented milk, 4-7 parts of melamine, 2-4 parts of a binder, 6-10 parts of dodecyl dimethyl benzyl ammonium chloride, 3-6 parts of campesterol, 1-5 parts of anhydrous ethanol, 2-5 parts of trifluoro(methanol)boron, 1-3 parts of methyl amyl carbinol, 2-6 parts of acephate and 1-4 parts of xylene. The pipronil-containing composite pesticide can be cooperatively used with other chemical reagents, has small toxicity, can quickly kill most insects, and can be used for a long term.

The invention relates to a preparation method of thiosulfonate compounds in water phase. In the method, sulfonyl hydrazide, accelerator, oxidizing agent and solvent water are added into a Schlenk reaction bottle, stirred and reacted under certain temperature and air atmosphere conditions, and thiosulfonate compounds are obtained through free radical coupling reaction.

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of Formula (2) with an aniline of Formula (3), as described herein. The present invention also relates to such methods which incorporate one or more additional (subsequent and/or preceding) steps, for example, to prepare compounds of Formula (5) from compounds of Formula (1); to prepare compounds of Formula (6) from compounds of Formula (5); and to prepare compounds of Formula (2) from compounds of Formula (4), as described herein.

The invention discloses a synthesis method of an asymmetric thiosulfonic acid compound, belongs to the field of organic synthesis, and mainly solves the problems of great environmental damage, high cost and the like in the prior art. The synthesis method specifically comprises the following steps: (1) dissolving sodium benzenesulfinate in an acetonitrile solvent; (2) adding sodium bicarbonate and iodine as catalysts for catalytic reaction, and cooling; and (3) evaporating to remove the solvent under reduced pressure, and purifying. According to the method, the use cost of a catalyst in an existing thiosulfonic acid compound synthesis method is remarkably reduced, reaction conditions are greatly simplified, and the technical problems that in a traditional method, raw materials are high in price, synthesis steps are tedious, and treatment is difficult after synthesis are solved; the asymmetric thiosulfonic acid compound is prepared by catalyzing sodium benzenesulfinate under the condition that iodine and sodium bicarbonate serve as catalysts, raw materials are easy to obtain and low in price, reaction conditions are mild, aftertreatment is simple, and the yield of the obtained target product is high.

The invention discloses a monochlorofluoromethyl thiosulfonate containing compound represented by a formula 1 shown in the description, a preparation method and an application. The preparation methodfor the compound represented by the formula 1 comprises the following step: subjecting a formula shown in the description to a reaction with sodium phenylsulfinate in a chlorine gas solution, therebyobtaining the compound. The compound represented by the formula 1 disclosed by the invention can serve as a monochlorofluoromethyl thiolation reagent and is high in application yield, thereby providing an important methodological research tool for the fields of medicines, pesticides and materials.