19 results about "Thiosulfonic Acids" patented technology

The invention provides an insecticidal double-water agent and a preparation method thereof, and relates to the technical field of pesticides, the insecticidal double-water agent comprises the following raw materials by weight: 90-95 parts of a sulfonation liquid, 3-8 parts of 4-chlorobenzyl chloride and 4-9 parts of magnesium chips. The preparation method specifically comprises the following steps: S1, preparing a Grignard reagent; s2, preparing concentrated sulfonation liquid; s3, reacting dimehypo with chlorine to prepare chloride; s4, enabling the Grignard reagent to react with chloride to generate 2-dimethylamino-2-p-chlorobenzyl chloro-1, 3-sodium dithiosulfonate propane; s5, enabling the 2-dimethylamino-2-p-chlorobenzyl chloro-1, 3-sodium dithiosulfonate propane to react with sodium thiosulfate, so as to prepare a sodium p-methanesulfonate insecticidal double-water agent; and S6, performing post-treatment on the sodium methanesulfonate insecticidal double water agent, and adding a synergist to obtain a final product. The dimehypo reagent prepared by the method disclosed by the invention is not crystallized at the high concentration of 36-43%, and the content of sodium hyposulfite is lower than 0.1%.

This invention provides a simple synthesis method for Fe-Ag / CMP nanopolymers with catalase-like activity and their application in hydrogen peroxide detection, belonging to the field of bioanalytical technology. The method of this invention includes the following steps: (1) preparing a 4-hydroxyethylpiperazine thiosulfonic acid (HEPES) standard buffer solution; (2) adding cytidine monophosphate (CMP) to the solution obtained in step (1) and stirring until the CMP is fully dissolved. Then, under vigorous stirring, ferric nitrate aqueous solution and silver nitrate aqueous solution are added sequentially, at which point the colorless solution turns pale yellow; (3) transferring the mixed solution obtained in step (2) to a centrifuge tube, centrifuging at 12000 rpm for 8 min to collect the precipitate, washing it three times with distilled water, and finally adding 4 mL of distilled water to obtain a 1 mg / mL Fe-Ag / CMP suspension. This invention utilizes CMP as a biological ligand and Ag... + Fe 3+ Simultaneous coordination, and the reducing amino groups on CMP can directly transfer Ag... + In situ reduction to silver nanoparticles (AgNPs) led to the one-step synthesis of a bimetallic Fe-Ag / CMP nanopolymer with hydrogen peroxide-like nanozyme activity, enabling the detection of hydrogen peroxide.

The invention relates to a sulfur-containing tryptophan cyclic peptide compound as well as a synthesis method and application thereof. The synthesis method comprises the following steps: carrying out electrolytic reaction on a tryptophan peptide compound with a structure as shown in a formula I or a stereoisomer thereof and a thiosulfonate compound with a structure as shown in a formula II to obtain the sulfur-containing tryptophan cyclic peptide compound with a structure as shown in a formula III or a stereoisomer thereof. The sulfur-containing tryptophan cyclic peptide compound can be obtained by directly electrolyzing the tryptophan peptide compound by adopting an electrochemical method, so that the use of a transition metal catalyst and stoichiometric alkali is avoided, the generation of chemical wastes is avoided, and the realization of atom economy is facilitated. The method has the advantages of simple operation, high product purity, easy purification, high efficiency and yield, low production cost, mild reaction conditions, no need of inert gas protection, greener reaction system, environmental protection, safety, economy, energy saving and environmental protection, and is more conducive to realization of industrial production.

The invention discloses a direct cross-coupling method of benzyl sulfonium salt and thiosulfonate, and belongs to the technical field of organic compound synthesis. The benzyl sulfonium salt and the sulfo-sulfonate react in the solvent under the action of the metal, and sulfonium alkane products with various structures are obtained at medium to good yield. According to the reaction, the benzyl sulfonium salt easy to synthesize is used as a coupling substrate, thiosulfonate is used as a substitute of mercaptan, risks such as stink in the operation process are avoided, meanwhile, the benzyl sulfonium salt can be stored at room temperature, shows excellent thermodynamic stability, and is very safe and easy to prepare compared with other electrophilic reagents. The preparation method disclosed by the invention has the characteristics of mild reaction conditions, simple post-treatment, green steps, low pollution, high economic benefits and the like.

The invention provides anthracene methyl thiosulfonate for a photosensitive resin composition, and relates to the field of photopolymerization. The invention also comprises a photosensitive resin composition containing the anthracene methyl thiosulfonate, a photosensitive dry film containing the anthracene methyl thiosulfonate, and applications of the photosensitive resin composition and the photosensitive dry film. The anthracene methyl thiosulfonate provided by the invention has photosensitivity, can be used as a photosensitizer in a photosensitive resin composition, can improve the adhesive force of the photosensitive resin composition on various metal surfaces, has the characteristic of low migration, has good compatibility with monomers and solvents, and can be widely applied to the photocuring fields of dry films, paints, coatings, inks, molding materials and the like; and the photobleaching agent has extremely high photobleaching efficiency and is particularly suitable for being used in a formula of an ultra-thick film.

The disclosure relates to organosulfur compounds and compositions comprising same. In particular, the disclosure relates to Bis(4-fluorophenyl) disulfide, Bis(4-chlorophenyl) disulfide, Bis(4-chlorophenyl) thiosulfinate, Bis(4-fluorophenyl) thiosulfinate, Bis(4-chlorophenyl) thiosulfonate, Bis(4-fluorophenyl) thiosulfonate, and Di-isopropyl thiosulfonate. Such compositions are useful for treating microbial infection, in particular bacterial, fungal, rotozoan or algal infection. Compositions comprising said compounds are also provided for cleaning, disinfecting or agricultural use.

This specification describes a method for the late modification of peptides and functionalized peptides. The method is specific and robust and allows for the precise construction of C2-sulfenylated tryptophan using sulfenyl reagents such as thiosulfonic acid ester (ArSO2SR) reagents. This simple C2-sulfenylation process allows for the easy introduction of a variety of functional groups, such as SCF3, SCF2H, SCF2Br, SCHFCl, SCF2-alkyl groups, SCHF-alkyl groups, S-alkyl groups, and S-aryl groups, into peptides, particularly tryptophan residues of natural peptides. Generally, a late peptide modification method comprises (i) the step of maintaining a reaction mixture at a sufficient temperature for a sufficient time to produce a product. The reaction mixture comprises a peptide to be modified containing one or more tryptophan residues, a sulfenyl reagent, and a solvent. The product produced in step (i) comprises a sulfenylated peptide, wherein the sulfenylation has occurred in at least one of the one or more tryptophan residues of the peptide.

The application discloses a direct cross-coupling method of benzyl sulfonium salt and thiosulfonate, and belongs to the technical field of organic compound synthesis. The benzyl sulfonium salt and the thiosulfonate are reacted under the action of a metal in a solvent, and various sulfonium alkane products with moderate to good yield are obtained. The reaction not only uses the benzyl sulfonium salt which is easy to synthesize as a coupling substrate, but also uses the thiosulfonate as a substitute for mercaptan, thereby avoiding the existence of a foul odor and other dangers in the operation process. In addition, the benzyl sulfonium salt can be stored at room temperature, and shows excellent thermodynamic stability. Compared with other electrophilic reagents, the benzyl sulfonium salt is very safe and easy to prepare. The preparation method has the characteristics of mild reaction condition, simple post-treatment, green step, low pollution and high economic benefit.

The invention belongs to the field of organic chemical synthesis, and relates to a method for realizing thiosulfonate alkylation based on a micro-flow field technology. The preparation method comprises the following steps: mixing a thiobenzene sulfonate compound 1 with a compound 2, an iron catalyst, a ligand and a first solvent to obtain a mixed solution; and pumping the mixed solution into a micro-flow field reactor of the micro-flow field reaction device to carry out photoreaction, thereby obtaining the sulfo-product 3. According to the method, alkane with low reaction activity is activated in the mode that the iron catalyst which is low in price and easy to obtain is excited to generate free radicals under purple light irradiation, and the alkane and thiosulfonate are subjected to cross coupling to achieve the thioalkylation modification reaction at the room temperature. According to the method, the condition is mild, an exogenous oxidant and an expensive transition metal complex do not need to be added, meanwhile, the reaction process is enhanced through the micro-flow field technology, the reaction efficiency is improved, the reaction time is greatly shortened, and a powerful foundation is laid for large-scale preparation of related products.

The application provides a preparation method of sulfonic acid ester in a sulfonic acid water phase, and belongs to the technical field of organic synthesis. The specific preparation method is as follows: aromatic sulfonic acid is added into water without catalyst and redox reagent, and sulfonic acid ester can be obtained by reacting for 2 hours at a temperature of 100 DEG C or above. The method has the advantages of simple raw material, high yield, mild reaction condition, easy control, less waste, and good social value and industrialization prospect.

The disclosure relates to organosulfur containing compositions, in particular di-n-propyl thiosulfonate (PTSO) and di-n-propyl thiosulfinate (PTS), di-methyl thiosulfonate, di-phenyl thiosulfonate. Such compositions are useful for as biostimulants for plants. In particular such compositions may result in increased nutrient use efficiency, increased tolerance to abiotic stress, and / or improved quality characteristics. Compositions comprising said organosulfur compounds are also provided for agricultural use.

The invention discloses a method for synthesizing a thiosulfonate compound through aerobic oxidative coupling, and relates to the technical field of organic synthesis.The synthesis method comprises the steps that a nitrogen-doped carbon-loaded cobalt-based catalyst is adopted, and in the oxygen or air atmosphere, a sulfydryl-containing compound and sulfonyl hydrazide are catalyzed to be subjected to an oxidative coupling reaction; the preparation process of the catalyst comprises the following steps: reacting cobalt salt with sodium dicyandiamide in a water phase to generate a dicyandiamide cobalt complex; mixing the complex with an ionic liquid containing dicyandiamide anions in proportion, stirring and drying to obtain an ionic liquid precursor of metal cobalt; and carbonizing the obtained precursor at a high temperature of 500-1000 DEG C in an inert atmosphere, etching for 2-10 hours by using a 1-6 mol / L hydrochloric acid solution, washing to be neutral, and drying to obtain the nitrogen-doped carbon-loaded cobalt-based catalyst. The catalyst used in the method is green, economical and recyclable, the reaction process is mild in condition and simple and convenient to operate, the product yield is excellent, and the method has a good application prospect.

The invention discloses a preparation method of a thiocarbamate compound. According to the method, an isocyanide compound and a sulfinic acid compound are used as raw materials, and a series of target products are conveniently prepared under the condition of an oxidizing agent. The method disclosed by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, very simple reaction system, convenience in operation, good substrate universality, high target product yield, safe production and environmental friendliness, and is suitable for industrial production. According to the process, sulfinic acid compounds are used as raw materials, so that the unpleasant smell of thioether and mercaptan and the hidden danger of safe production in the prior art are avoided; meanwhile, a series of problems that thiosulfonate, sulfonyl hydrazide and the like need to be prepared in advance, the technological process is tedious and the like are solved.

The application provides a method for catalytically synthesizing (E)-beta-thio vinyl sulfone compounds by using organic semiconductor carbon nitride, and relates to the technical field of organic synthesis. The synthesis method provided by the application uses thiosulfonate and alkyne compounds as reaction substrates, uses graphite phase carbon nitride g-C3N4 prepared by urea thermal polycondensation as a heterogeneous photocatalyst, and makes the atom transfer radical addition reaction occur under the condition of an organic solvent and light to obtain the (E)-beta-thio vinyl sulfone compound. The application provides a new path for the synthesis of (E)-beta-thio vinyl sulfone compounds, and the yield is high. The synthesis method of the application uses organic semiconductor carbon nitride as a photocatalyst, and has the advantages of easy availability of raw materials, simple process, mild reaction conditions, green environmental protection and the like. The synthesis method of the application has wide substrate applicability, and can be used to synthesize various (E)-beta-thio vinyl sulfone compounds by using different substrates.

The application discloses a method for constructing asymmetric sulfenyl sulfonate by electrochemical oxidation in an aqueous phase, which successfully realizes the construction of asymmetric sulfenyl sulfonate by electrochemical oxidation-nucleophilic substitution reaction in an aqueous phase. The reaction uses sodium sulfinate and disulfide as raw materials to efficiently synthesize asymmetric sulfenyl sulfonate compounds, and for the first time realizes the dual function of water as a solvent and a reactant. The method is carried out at room temperature, has mild reaction conditions, a simple process and easy operation, and does not need to use organic solvents, metal catalysts and chemical oxidants, thereby reducing the generation of chemical waste reagents and being more friendly to the environment. In addition, the antibacterial performance of the sulfenyl sulfonate is evaluated, and it is found that S-isopropyl 4-methyl benzene sulfenyl sulfonate shows good antibacterial activity on staphylococcus aureus and streptococcus mutans, which indicates that the method has a wide application market.

Described herein are methods for late modification of peptides and functionalized peptides. In particular, the methods are specific and robust, which results in the precise construction of C2-hydrothiolated tryptophan by means of a hydrocarbon thio-based reagent, such as a thiosulfonate (ArSO2SR) reagent. A simple C2-hydrocarbon sulfhydrylation process makes it possible to readily introduce various functional groups, such as SCF3, SCF2H, SCF2Br, SCHFCl, SCF2-alkyl, SCHF-alkyl, S-alkyl, S-aryl, and the like onto tryptophan residue (s) of a peptide, in particular a natural peptide. In general, a method of late peptide modification includes: (i) maintaining a reaction mixture at a sufficient temperature for a sufficient time to form a product. The reaction mixture comprises a modified peptide comprising one or more tryptophan residues, a hydrocarbon thio-based reagent, and a solvent. The product formed in step (i) contains a hydrocarbonylated peptide, wherein hydrocarbonylation occurs on at least one of the one or more tryptophan residues of the peptide.

Preferably, the compound comprises di-n-propyl disulfide, dimethyl disulfide, diethyl disulfide, diisopropyl disulfide, di-n-butyl disulfide, dibenzyl disulfide, diethyl sulfide, di-n-propyl sulfide, diisopropyl sulfide, di-n-butyl sulfide, diphenyl sulfide, dibenzyl sulfide, di-n-propyl trisulfide and di-n-propyl sulfone. The compound is selected from dibenzyl thiosulfinate, dibenzyl thiosulfinate, diisopropyl thiosulfinate, di-n-propyl thiosulfinate (PTSO) and di-n-propyl thiosulfinate (PTS).

This invention provides anthracene methyl thiosulfonate for use in photosensitive resin compositions, relating to the field of photopolymerization. The invention also includes photosensitive resin compositions containing the anthracene methyl thiosulfonate, photosensitive dry films containing the anthracene methyl thiosulfonate, and their applications. The anthracene methyl thiosulfonate of this invention is photosensitive and can be used as a photosensitizer in photosensitive resin compositions. It can also improve the adhesion of photosensitive resin compositions to various metal surfaces, exhibits low migration characteristics, and has good compatibility with monomers and solvents. It can be widely used in photocuring fields such as dry films, paints, coatings, inks, and molding materials; it has extremely high photobleaching efficiency and is particularly suitable for use in ultra-thick film formulations.

The invention relates to a tandem cyclization reaction of photocatalytic diallyl compounds. The invention relates to a photocatalytic cascade cyclization reaction of diallyl compounds, which comprises the following steps: mixing a diallyl compound and a thiosulfonate compound in a solvent, and stirring to react under the conditions of visible light irradiation and room temperature to obtain a bifunctional cyclization product; the diallyl compound is diallyl diethyl malonate or diallyl diphenyl silane, and the diallyl compound is diallyl diethyl malonate or diallyl diphenyl silane. According to the series cyclization reaction of the photocatalytic diallyl compound, the cyclization reaction without participation of a photocatalyst and an additive is completed through visible light induction on the basis of the diallyl compound, and a novel efficient, simple, convenient and environment-friendly bifunctional cyclization strategy is established; regioselective functionalization reaction is completed through different diallyl compounds, generation of by-products is greatly reduced, the yield of target products is improved, and expansibility is improved through wide thiosulfonate substrates.