Process for manufacture of in vivo stain composition

a technology of in vivo stain composition and manufacturing process, which is applied in the direction of drug compositions, applications, instruments, etc., can solve the problems of reducing yield, reducing product purity, and reducing yield
US20010007904A1Inactive Publication Date: 2001-07-12DEN MAT HLDG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
DEN MAT HLDG
Publication Date
2001-07-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-rho-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.
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Description

[0001] This application is a continuation of my co-pending U.S.A. application, Ser. No. 09 / 110,788, filed Jul. 6, 1998, which was, in turn, a continuation-in-part of International Application, PCT US / 97 / 20981, filed Nov. 13, 1997, entitled IN VIVO STAIN COMPOSITION, PROCESS OF MANUFACTURE, AND METHODS OF USE TO IDENTIFY DYSPLASTIC TISSUE.

[0002] This invention pertains to improved methods of manufacturing TBO compositions, including the novel compositions which are disclosed in my above-identified prior applications.

[0003] In another aspect, the invention concerns a method and process for manufacturing TBO compositions with improved yield, leading to manufacturing economies and increased productive capacity of the manufacturing equipment.

[0004] The various embodiments of the invention and the practice thereof will be apparent to those skilled in the art, from the following detailed description thereof, taken in conjunction with the claims and in conjunction with the drawings, in whic...

Claims

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