36 results about "Pathogenic organism" patented technology

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.

Containers for growth of cryo-sprouts with reduced numbers of pathogenic organisms. The covered containers have an air-permeable seal and may also have additional openings to increase the air permeability rate of the covered container. The air permeability rate is balanced to have sufficient air exchange but with an evaporation rate that is low enough to avoid addition of water during germination and growth of the cryo-sprouts. The seeds and sufficient water are added to the container and covered with a lid to form an air-permeable covered container. The seeds germinate and grow in the covered container at pathogen antagonistic temperature without the removal of the lid until use by consumer. This results in cryo-sprouts that have reduced numbers of pathogenic organisms, are greener, and have an extended shelf-life.

The utility model discloses an aquatic product fry breeding device which comprises a bracket seat and a breeding groove, a filter screen assembly is fixedly installed on the inner side of the upper portion of the breeding groove, a first upper connector and a second upper connector are arranged on the outer side of the breeding groove, the first upper connector is connected with a drainage pipeline, the second upper connector is connected with a filtering circulation assembly, and the lower portion of the breeding groove is a conical bottom shell. The conical bottom shell is provided with a bottom connector and a side connector, the bottom connector is connected with a seedling emergence pipeline and a water inlet pipeline, the side connector and the bottom connector are connected through an anti-sinking pipeline, the water inlet pipeline is connected with a filtering circulation assembly, an inflation pipe with the bottom end connected with an air stone in an inserted mode is fixed in the cultivation tank, and the air stone is located at the bottom of the conical bottom shell. A drainage control valve is mounted on the drainage pipeline, a first water inlet control valve, a sterilization device and a second water inlet control valve are mounted on the water inlet pipeline, and a seedling emergence control valve is mounted on the seedling emergence pipeline. By the adoption of the device, the water changing amount can be reduced, pathogenic organisms can be killed, water quality is purified, and the survival rate of aquatic fry is increased.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

Provided herein is technology relating to vaccines and particularly, but not exclusively, to compositions, methods, and uses of a mixture of immunogenic vaccine molecules comprising components for targeting the dimeric vaccine molecules to antigen-presenting cells and components for eliciting an immunogenic response, wherein the components for eliciting an immunogenic response preferably comprise at least three variants of an immunogenic protein, such as variants of immunogenic proteins obtained from three or more different strains of a pathogenic organism.

The invention discloses a facility circulating water separation grading culture method for micropterus salmoides. The method comprises the following steps: identifying the sex of the micropterus salmoides according to specific primers, and separating the sex of the micropterus salmoides from the sex of the micropterus salmoides; according to different growth speeds of male and female micropterus salmoides and individual micropterus salmoides, a three-stage breeding mode is adopted, and sequencing batch type grading breeding is carried out; special compound feed for male and female micropterus salmoides is fed; a corresponding feeding strategy is adopted according to the conditions of weight, water temperature, water quality and the like; the organism health of micropterus salmoides is enhanced by adopting a composite technical means, the microenvironment stability of a culture water body is regulated and controlled, and stress damage caused by environmental fluctuation and pathogenic organisms is reduced. According to the method for culturing the micropterus salmoides in a classified manner through facility circulating water separation, the single-pond yield of the micropterus salmoides cultured in the facility circulating water can be effectively improved, meanwhile, the culture cost is reduced, the culture benefit is improved, off-peak marketing is achieved, and efficient and sustainable development of facility fishery is maintained.

Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

The present invention embraces compositions comprising at least two RNA replicons (self-amplifying RNA vectors (saRNAs or rRNAs)) that can be replicated by a replicase of a self-replicating virus, e.g., a replicase of alphavirus origin. Of the at least two replicons, at least one of which optionally comprises an open reading frame encoding for the RNA-dependent RNA polymerase or replicase that is able to replicate each of the at least two replicons. Further, each replicon comprises an open reading frame encoding for different antigens of interest, e.g., different antigens derived from the same or from different pathogenic organisms, for example the glycoprotein and nucleoprotein of Ebola virus.

The present disclosure relates to methods for analyzing nucleic acid molecules present in a sample, wherein the DNA molecules present in the sample or derived from nucleic acids in the sample are contacted with a terminal deoxynucleotidyl transferase to add nucleotides to the 3' end of the DNA molecules in a step-wise fashion and then identifying the contacted DNA molecules by their sequence. The method can be advantageously used in methods of diagnosing diseases caused by pathogenic organisms, as well as detecting the presence of pathogenic organisms in the environment.

The invention relates to the technical field of bioinformatics and medical diagnosis, in particular to a method for screening bipolar affective disorder and epilepsy co-pathogenic biomarkers, which comprises the following steps of: performing differential expression analysis on known gene chip expression profile data and finding out a significant correlation module by using a WGCNA algorithm so as to determine key differential genes; finding out hub genes in the core differential genes by using a PPI network, and screening out candidate core pathogenic genes of the bipolar affective disorder and the epilepsy by taking the result intersection of three machine learning methods of LASSO regression, support vector machine recursive feature elimination and random forest; the screened marker can be used for prediction and early prediction of bipolar affective disorder and epilepsy, early screening can be better completed, and a new perspective is provided for molecular mechanism research and early diagnosis of bipolar affective disorder and epilepsy co-pathopoiesis.

Devices, kits and methods are provided to reduce or even eliminate fecal contamination and cross-contamination and transmission of fecal-born pathogenic organisms by users employed in the food production and food preparation industries or users in a home, for example in restaurants, cruise ships, schools, hospitals, dormitories, transportation means and terminals, and government buildings, the devices and methods pertaining to a glove-like garment that is applied prior to disposal of feces and removed after disposal of toilet tissue. The glove is flushable, and in an embodiment includes means of retraction from the wrist area for inversion of the garment, followed by flushing the inverted removed glove.

Containers for growth of cryo-sprouts with reduced numbers of pathogenic organisms. The covered containers have an air-permeable seal and may also have additional openings to increase the air permeability rate of the covered container. The air permeability rate is balanced to have sufficient air exchange but with an evaporation rate that is low enough to avoid addition of water during germination and growth of the cryo-sprouts. The seeds and sufficient water are added to the container and covered with a lid to form an air-permeable covered container. The seeds germinate and grow in the covered container at pathogen antagonistic temperature without the removal of the lid until use by consumer. This results in cryo-sprouts that have reduced numbers of pathogenic organisms, are greener, and have an extended shelf-life.

The invention is directed to disinfection of object(s) in a space using a UV emitter. A calibration process is performed in which one or more UV sensors are placed proximate the object or set of objects to be disinfected. The sensor(s) measure a UV dose and the time taken for the UV dose to equal to a level suitable for disinfection to occur to the required level is measured. This is saved in a database in association with an identification of the object(s) being disinfected. This saved program can be activated subsequently and without the sensors present to disinfect the object(s). In addition to the calibration process, or in the alternative, the controller may enable the operator to select a particular pathogenic organism or set of organisms as a target of the disinfection process, with the controller accessing the database to obtain a disinfection program specific to the target.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The present disclosure relates to a composition and a method of making microgel particles with antimicrobial properties, for example, for packaging, food, textiles, and medical applications. In an implementation, an antimicrobial microgel comprises: a first peptide comprising arginine, the first peptide in a concentration of about 0.1 mg / mL to about 20 mg / mL; an organic acid in a concentration of about 0.6mg / mL to about 20 mg / mL, and a second peptide comprising at least one amine group, the second peptide in a concentration of about 0.4 mg / mL to about 8 mg / mL, and a method of making the same. These particles may be used as a stand-alone antimicrobial in liquid or as a coating on surfaces. The antimicrobial microgel may be used to provide antimicrobial food packaging including a non-migrating antimicrobial surface for controlled and sustained protection against spoilage or pathogenic organisms without compromising the integrity or flavor of the packaged food.

The present disclosure relates to a composition and a method of making microgel particles with antimicrobial properties, for example, for packaging, food, textiles, and medical applications. In an implementation, an antimicrobial microgel comprises: a first peptide comprising arginine, the first peptide in a concentration of about 0.1 mg / mL to about 20 mg / mL; an organic acid in a concentration of about 0.6mg / mL to about 20 mg / mL, and a second peptide comprising at least one amine group, the second peptide in a concentration of about 0.4 mg / mL to about 8 mg / mL, and a method of making the same. These particles may be used as a stand-alone antimicrobial in liquid or as a coating on surfaces. The antimicrobial microgel may be used to provide antimicrobial food packaging including a non-migrating antimicrobial surface for controlled and sustained protection against spoilage or pathogenic organisms without compromising the integrity or flavor of the packaged food.

Described herein are fusion proteins and methods of using those fusion proteins for the detection and identification of analytes (e.g., multimeric proteins expressed by pathogenic organisms or mammalian cells). In some embodiments, it includes a plurality of pairs of fusion proteins distinct for one analyte wherein each pair comprises i) a first fusion protein comprising one or more binding domains fused to a first portion of a reporter protein, and ii) a second fusion protein comprising one or more binding domains fused to a second portion of the same reporter protein, wherein the first and second portions of the reporter protein, when together, comprise the reporter protein in its entirety and restore its function, wherein the first fusion protein and / or the second fusion protein further comprises a fluorophore, and wherein the fluorophore for each pair has a distinguishable emission spectrum.

This invention discloses a method and system for detecting pathogenic organisms in aquatic bodies, belonging to the field of biological detection technology. Based on historical hydrological data and meteorological forecasts, a spatiotemporal distribution model of microbial concentration is constructed to generate a set of coordinates for suspected high-risk areas for pathogens. An unmanned surface vessel (USV) automatically cruises according to the coordinates and conducts water sampling and membrane enrichment, while simultaneously monitoring water temperature, pH, turbidity, and enrichment membrane pressure difference in real time, dynamically determining whether to terminate sampling. After the enriched samples are activated by electric field, magnetic field, or temperature control, real-time quantitative PCR is performed to obtain Ct values ​​at each location, calculate the offset density cumulative index, and identify areas with strong positive signals. Finally, based on the Ct value distribution and prediction results, a spatial distribution map and multi-level concentration map of pathogenic organisms are output for water quality risk assessment and emergency response. This invention has highly automated, spatially accurate, and intelligent analysis capabilities, and is suitable for pathogen monitoring and dynamic early warning in large-scale complex water bodies.

Devices and methods are described for disinfection of pathogenic organisms using pulsed DC field electroporation. For example, this disclosure describes disinfection of pathogenic organisms using pulsed DC field electroporation for lung infection treatment, blood infection treatment, sterilization, and respirators.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The present disclosure relates to methods for analyzing nucleic acid molecules present in an obtained sample, such as cell-free DNA molecules, wherein the nucleic acid molecules present in the sample are contacted in the sample with a terminal deoxynucleotidyl transferase to add nucleotides to the 3 ' end of the DNA molecules in a step-wise fashion and then identifying the contacted DNA molecules comprising the added nucleotides by their sequence. The method can be advantageously used in methods of diagnosing diseases caused by pathogenic organisms, as well as detecting the presence of pathogenic organisms in the environment.

A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of a patient infected with pathogenic organisms; wherein X and Y are each independently selected from C, N, O and S, provided at least one of X and Y is N, O or S; wherein R1 and R2 are each independently selected from an optionally substituted C1-C8 alkyl, C1-C8 alkenyl, aryl, heteroaryl or alkylaryl group; and wherein Z is selected from H, —CN, —NO2, —NR3R4, —NR5(CO)R6; C1-C4 alkyl, C1-C4 alkoxy, —(CO)WR12, hydroxy, amino, thiol, chloro, fluoro, CF3, CHF2 or CH2F groups. The compounds may be effective in treating patients / animals infected with parasites selected from Schistosoma, Haemonchus, Eimeria, Echinococcus, Dirofilaria, Fasciola or Plasmodium parasites. Additionally or alternatively, the compounds of formula (I) may be effective in treating patients infected with pathogenic bacteria selected from S. aureus, MRSA and Enterococcus faecalis.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The invention describes a novel method and alcohol-based compositions for the topical treatment of Treponema-associated digital dermatitis in equines, containing at least one or more different monohydric alcohol compounds, characterized in that they additionally contain at least one or more surfactants, one or more polyhydric alcohol compounds, and may further contain, depending on the intended use, one or more aldehyde compounds, one or more organic and / or inorganic acids, one or more organic and / or inorganic basic compounds, one or more inorganic and / or organic salts, one or more compounds from the group of essential oils, and active ingredients that are subject to drug regulations and, in particular, originate from the group of antibiotics. These products can also be used as cleaning and disinfecting agents on keratinized body parts and the coat of horses colonized with pathogenic organisms, as sprays, bath additives, or in gel form. The procedure particularly includes therapy in combination with the systemic administration of antimicrobial agents from the macrolide or penicillin groups.

The invention relates to an indoor marsupenaeus japonicus offspring seed roughing culture method. The method comprises the following steps: (1) treating a roughing cement pond; the method comprises the following steps: (1) selecting an indoor cement pond for standard coarsening with the area of 10-100m < 3 > and the depth of about 1-2m, (2) feeding water, (3) fertilizing water: using fermented soybean meal and urea in an independent pond for rotifer cultivation (the inoculation density is 500,000 / mL), and putting the rotifer into a standard coarsening pond after the rotifer density reaches 2,000,000 / mL; (4) putting the young shrimps, (5) inoculating the copepods, (6) performing early-stage and daily management, and completing the thickness marking 20 days after the young shrimps are put until the sizes of the young shrimps reach 2.5-3cm. Through a symbiotic mode of microorganisms and shrimp seeds in the bait, growth of pathogenic organisms such as vibrio is inhibited, the survival rate of the shrimp seeds is increased, meanwhile, the utilization efficiency of the bait is optimized, the breeding cost is reduced, and therefore the overall economic benefit is improved.

The present disclosure provides compositions and methods related to inhalable treatments. In particular, the present disclosure provides hydrogel-based inhalable bioadhesives that safely and effectively cover the airway to provide a barrier against pathogenic organisms, allergens, and environmental contaminants.

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.

The present invention provides a computer-implemented method for determining at least one therapeutic target region on a candidate protein of a target pathogenic organism, the method comprising: a) identifying pairs of invariant and / or lethal synthetic residues, called target residues, in a set of pre-aligned nucleotide and polypeptide sequences characteristic of a candidate protein (E1); b) identifying at least one candidate region (E2) consisting of at least one pair of target residues identified in step a), wherein at least one pair is located at a determined distance in space and comprises target residues exposed on the surface of the candidate protein, preferably in a pocket; c) determining (E3) from the 2D and / or 3D structure of the candidate protein favorable chemical interactions between each residue and / or each pair of residues in the candidate protein, wherein the favorable chemical interactions are hydrophobic bonds and / or hydrogen bonds and / or salt bridges and / or negative repulsive bonds and / or positive repulsive bonds; d) selecting residues that are linked by favorable chemical interactions, the residues being at a distance of at most 10 Angstroms (E4); e) selecting from among the candidate regions identified in step b) at least one therapeutic target region comprising the residue selected in step d) (E5).