Topical drug delivery using phosphatidylcholine

a technology of phosphatidylcholine and drug delivery composition, which is applied in the direction of drug composition, peptide, metabolic disorder, etc., can solve the problems of ineffective and economical method of transporting such molecules, large molecules such as insulin, and only being useful

Inactive Publication Date: 2006-05-18
TRANSDERMAL BIOTECHNOLOGY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these systems have typically only been useful for transdermal delivery of relatively small molecules.
However, large molecules, such as insulin, are not able to diffuse through the skin.
To date there has not been an effective and economical method to transport such mole

Method used

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Embodiment Construction

[0008] Phosphatidylcholine is used as a carrier for the topical drug delivery of macromolecules in the practice of this invention. Phosphatidylcholine is a basic component of cell membrane bilayers and the main phospholipid circulating in the plasma. Phosphatidylcholine is highly absorbable and supplies choline which is needed to facilitate movement of fats and oils across and maintain cell membranes in animals.

[0009] Phosphatidylcholine compositions (herein abbreviated “PC compositions”) of the present invention are formulated to contain macromolecules soluble in PC, which are then applied to skin for transdermal delivery of the macromolecule. PC compositions of the invention are efficacious in the delivery of macromolecular drugs that are conventionally administered intramuscularly, intravenously or orally, including, but not limited to polypeptides such as insulin and somatropin, prostaglandins, glucocorticoids, estrogens, androgens, and the like.

[0010] It is an advantage of th...

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Abstract

The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin.

Description

PRIOR APPLICATION [0001] This application is a divisional patent application of copending U.S. patent application Ser. No. 10 / 448,632 for “Topical Drug Delivery Using Phosphatidylcholine,” filed May 30, 2003, which claims priority benefits under 35 U.S.C. §119(e) of U.S. Provisional Patent Application Ser. No. 60 / 384,597 filed May 31, 2002.FIELD OF THE INVENTION [0002] The present invention relates to a topical drug delivery composition and method. More specifically, this invention relates to topical drug delivery compositions and methods using phosphatidylcholine. BACKGROUND OF THE INVENTION [0003] Transdermal drug delivery systems may be designed to act locally at the point of application or to act systemically by entering the body's blood circulation. In these systems, delivery may be achieved by direct topical application of a substance or drug in the form of an ointment or the like, or by adhesion of a patch with a reservoir that holds the drug and releases it to the skin in a ...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K38/22A61K38/27A61K9/127A61K38/00A61K38/095A61K38/23A61K47/20A61K47/22A61K47/24
CPCA61K9/127A61K47/34A61K38/27A61K38/28A61K47/24A61J3/07A61K9/0014A61K47/10A61K9/02A61K9/06A61K31/56Y10S514/866Y10S514/808Y10S514/97Y10S514/807Y10S514/806A61K38/02A61K38/11A61K38/24A61K38/23A61K38/31A61K47/14A61K38/56A61K47/22A61K9/1277A61K38/095A61P17/00A61P5/06A61P3/10C07K14/62
Inventor PERRICONE, NICHOLAS V.
Owner TRANSDERMAL BIOTECHNOLOGY INC
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