Expandable vaginal suppository

A technology of vaginal suppository and swelling value, which is applied in suppository delivery, absorbent pads, pharmaceutical formulations, etc. It can solve the problems of low curative effect, strong discomfort, and contamination of clothes, and achieve the effect of overcoming poor compliance and strong discomfort

Active Publication Date: 2013-07-03
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] above-mentioned vaginal suppositories are all committed to solving the problem of more accurately providing medicine to the diseased site and contaminated clothing with medicinal liquid, but generally speaking, there are still the following deficiencies: 1. activity Components are not in sufficient contact with the vaginal epithelium and mucous membrane wall, let alone selective contact; 2. The vagina is an open organ, and the medicine can easily slip off or flow out of the medicine liquid after melting or dissolving in the vagina, causing contamination of clothes, and the existing technology solves the pr

Method used

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  • Expandable vaginal suppository
  • Expandable vaginal suppository
  • Expandable vaginal suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Such as figure 1 As shown in the expanded vaginal suppository 11 of the present invention, the drug-containing matrix layer 12 surrounds the sterile expanded tampon 13 and the permeable medicated gauze 14 that wraps it in a semi-enclosed state. combine figure 2 As shown, there is an axial keel 14 on the surface of the sterile expanded tampon 13, and a backguy 15 at the tail. After the expansion vaginal suppository 11 expands in the vagina 16, the pull-out end 17 expands earlier, and combines image 3 Shown is the state of the expanded vaginal suppository 11 after expansion.

Embodiment 2

[0048] Such as Figure 4 As shown, it is the state before the expansion vaginal suppository 21 of the present invention is put into the vagina 22 before it expands. When encountering the liquid in the vagina 22, it can rapidly expand as Figure 5 As shown in the expanded state, it can be seen that the expansion range of the pull-out end 23 of the inflatable vaginal suppository 21 is greater than that of the entry end, and several annular protrusions 24 are close to the vaginal wall, which is beneficial to the absorption of the drug and avoids drug absorption. The liquid flows out, and the multiple ring-shaped protrusions are adsorbed respectively, instead of passively intercepting the medicine that is easy to slip off or flow out after melting or dissolving in the vagina, but the medicine is divided, adsorbed and intercepted by different expansion parts of the first expansion carrier 31, clean thorough.

Embodiment 3

[0050] Such as Image 6 As shown in the expansive vaginal suppository 31, the protective layer is three non-woven fabrics 32 of different volumes, which are respectively placed on the pull-out end and the entry end of the expansion carrier before expansion. After expansion, as shown in FIG. Figure 7 As shown, the non-woven fabric 32 can limit the expansion range of the expansion carrier 33 .

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Abstract

The invention relates to an expandable vaginal suppository which comprises a first expansion carrier; a stype layer comprising active constituents and a matrix is used for at least covering an end part of the first expansion carrier; the vaginal suppository is expanded in a water solution with the pH value of 3.0-8.0 according to the predetermined expansion value; and the expansion value of the first expansion carrier in the saturated water absorption process is 1-30. The vaginal suppository can be fully and selectively contacted with vaginal epithelium and mucosal wall, the bioavailability of active drugs is averagely improved by 20-40%, and different positions of a suppository body can be expanded to different degree, so that the problem of low possibility of cleaning a sliver vaginal suppository is thoroughly solved and the problems of poor user compliance, strong discomfort and the like are avoided.

Description

Technical field [0001] The invention involves an expansion vaginal suppository that transports drugs, which specializes in a vaginal suppositories that can expand the expansion value according to the scheduled expansion value. Background technique [0002] Vaginal suppositories refer to solid preparations made of drugs and appropriate matrix for vaginal administration.The vaginal bolt is generally duck -billed, spherical or ovate, etc., which can be made to make ordinary bolt or continuous release of slow -release bolt.The matrix of water -soluble or water can be used to prepare vaginal bolt.The drugs and matrix in the suppositories should be mixed evenly, the shape of the suppositories should be complete and smooth; there should be no irritation after the cavity channel, it should be melted, softened or dissolved, and mixed with the secretion liquid to gradually release the drug and produce local or systemic effects; There should be a suitable hardness to avoid deformation durin...

Claims

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Application Information

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IPC IPC(8): A61K9/02
CPCA61F13/2074A61F13/202A61F13/2028A61K9/0034A61K9/02
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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