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Compound miconazole nitrate emulsifiable paste and preparation technology thereof

A technology of miconazole nitrate cream and miconazole nitrate, applied in ointment delivery, pharmaceutical formulation, emulsion delivery, etc. In order to avoid problems such as poor skin absorption effect, it can achieve good antibacterial and bactericidal effects, good curative effect for external use, and remarkable curative effect

Inactive Publication Date: 2019-05-31
JIANGSU YUANHENG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Integrating the miconazole nitrate cream formula and its preparation process in the prior art, it is found that there are still problems as follows: 1. It is not easy to disperse and apply, and after application, the problem of greater damage to human skin is not effective in transdermal absorption. Poor; 2. In the process of preparing cream, the raw materials, water phase and oil phase are not easy to be mixed and compatible, and the quality, stability and curative effect of the cream cannot be guaranteed

Method used

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  • Compound miconazole nitrate emulsifiable paste and preparation technology thereof
  • Compound miconazole nitrate emulsifiable paste and preparation technology thereof
  • Compound miconazole nitrate emulsifiable paste and preparation technology thereof

Examples

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Embodiment 1

[0029] The present embodiment provides a kind of compound miconazole nitrate emulsifiable cream, comprises the raw material of following parts by weight: 6 parts of miconazole nitrate, 1.8 parts of clobetasol propionate, 6.5 parts of sodium lauryl sulfate, 9 parts of glycerol 0.17 parts of chondroitin sulfate, 1.2 parts of sodium alginate, and 17 parts of absorption enhancers.

[0030] The absorption enhancer includes the following components by weight: 3.5 parts of disodium ethylenediaminetetraacetic acid, 6.5 parts of nicotinamide, 6 parts of Tween 80, and 21 parts of honey; the preparation process of the absorption enhancer is as follows: the ethylenediaminetetraacetic acid Put the disodium, Tween 80, and honey into a vacuum degassing mixer in advance, stir evenly at a speed of 50 rpm, then add nicotinamide, increase the speed to 100 rpm, and vacuum defoam for 12 minutes.

[0031] The preparation technology of present embodiment compound miconazole nitrate cream comprises t...

Embodiment 2

[0036] The present embodiment provides a kind of compound miconazole nitrate emulsifiable cream, comprises the raw material of following parts by weight: 5 parts of miconazole nitrate, 2.3 parts of clobetasol propionate, 5.5 parts of sodium stearate, 10 parts of glycerol, 0.22 parts of chondroitin sulfate, 1.5 parts of sodium alginate, 20 parts of absorption enhancer.

[0037]The absorption enhancer includes the following ingredients in parts by weight: 4.6 parts of disodium edetate, 7 parts of nicotinamide, 806 parts of Tween, and 18 parts of honey; the preparation process of the absorption enhancer is as follows: ethylenediaminetetraacetic acid di Put sodium, Tween 80, and honey into a vacuum defoaming mixer in advance, stir evenly at a speed of 60 rpm, then add nicotinamide, increase the speed to 110 rpm, and vacuum defoam for 13 minutes. The preparation technology of present embodiment compound miconazole nitrate cream comprises the following steps:

[0038] S1. Put micon...

Embodiment 3

[0042] The present embodiment provides a compound miconazole nitrate cream, comprising the following raw materials in parts by weight: 7 parts of miconazole nitrate, 2.5 parts of clobetasol propionate, 7.3 parts of potassium stearate, 10 parts of glycerol, 0.23 parts of chondroitin sulfate, 1.6 parts of sodium alginate, 20 parts of absorption enhancer.

[0043] The absorption enhancer includes the following components by weight: 4.2 parts of disodium edetate, 6.6 parts of nicotinamide, 5.5 parts of Tween 80, and 23 parts of honey; the preparation process of the absorption enhancer is as follows: ethylenediaminetetraacetic acid Put the disodium, Tween 80, and honey into the vacuum defoaming mixer in advance, stir evenly at the speed of 46 rpm, then add nicotinamide, increase the speed to 95 rpm, and vacuum defoam for 15 minutes.

[0044] The preparation technology of present embodiment compound miconazole nitrate cream comprises the following steps:

[0045] S1. Put miconazole...

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Abstract

The invention discloses a compound miconazole nitrate emulsifiable paste and a preparation technology thereof. According to the compound emulsifiable paste, miconazole nitrate and clobetasol propionate are adopted as main drug ingredients, a surface active agent and chondroitin sulfate are adopted as functional auxiliary additives, sodium alga acid is adopted as a thickening agent, glycerol is adopted as a lubricating moisture absorption agent, and on the basis of an absorption enhancer, the paste is prepared by grinding, smashing, vacuum mixing, vacuum stirring and refrigeration; the main drugs, the auxiliary additives and the enhancer are good in compatibility, and the external use treatment effect on tinea corporis, tine cruris, tine manuum, tine pedis, tinea versicolor, mycotic paronychia and monilial vaginitis caused by dermatophytes, saccharomycetes and other fungi is good.

Description

technical field [0001] The invention relates to the technical field of cream preparations, in particular to a compound miconazole nitrate cream and a preparation process thereof. The compound miconazole nitrate cream is used for tinea corporis and other diseases caused by dermatophytes, yeasts and other fungi. External treatment of jock itch, tinea manuum, tinea pedis, tinea versicolor, fungal paronychia, and candidal vaginitis. Background technique [0002] Miconazole nitrate is a synthetic 1-phenylethylimidazole derivative, which belongs to imidazole broad-spectrum antifungal drugs. It is a commonly used drug for treating skin ringworm. It does not contain hormones and has no toxic and side effects. Conazole. The oral absorption effect is poor, and after local administration, it mainly stays in the lesion, and absorbs little into the body. In the body, it is distributed in various tissues and fluids in the body, and can penetrate into inflamed joints, vitreous body and p...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K31/4174A61K9/06A61K47/36A61K47/10A61K47/18A61K47/26A61K47/46A61K47/22A61P31/10A61P17/00A61P15/02A61P31/02
Inventor 不公告发明人
Owner JIANGSU YUANHENG PHARMA
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