Antibacterial film-forming high-molecule liquid and preparation method thereof

Abstract

The invention provides antibacterial film-forming high-molecule liquid and a preparation method thereof. The antibacterial film-forming high-molecule liquid comprises solvents, high-molecule film-forming materials, antibacterial components, plasticizers, penetration enhancers and pH (potential of hydrogen) conditioning agents. The high-molecule film-forming materials are selected from one or moreof acrylic copolymers, Carbomer, polyvinyl alcohol, polyvinyl butyral, cellulose and chitosan derivatives. The antibacterial components are selected from one or more of chlorhexidine acetate, ZPT (zinc pyrithione), Casson, miconazole nitrate, terbinafine hydrochloride, Ketoconazole and amorolfine hydrochloride. Compared with traditional cream or baste, the antibacterial film-forming high-moleculeliquid is more convenient to use, antibacterial molecules do not easily lose when the liquid touches water or a user sweats after an affected part is coated with the antibacterial film-forming high-molecule liquid, and antibacterial effects are good.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations and disinfectants, in particular to a bacteriostatic film-forming polymer coating solution and a preparation method thereof. Background technique [0002] Infectious skin diseases caused by superficial fungi are on the rise. Dermatophytes are the main pathogenic species, followed by Candida, yeast, mold, etc. In skin and onychomycosis, trichophyton rubrum bacteria are most common. If the curative fungus will form onychomycosis when infecting nails, the patient is not easy to cure after being ill, which affects daily work and appearance. Generally can use the method for oral medicine and operation to pull out nail to treat onychomycosis, but these treatment cost of onychomycosis effect is high, and patient is miserable. Antifungal ointment is the antifungal drug (miconazole nitrate cream; Terbinafine hydrochloride cream; Amorolfine hydrochloride cream) widely used at present, ...

AI Technical Summary

Problems solved by technology

If the treatment fungus infects the nails, it will form onychomycosis, and the patient is not easy to cure after the disease, which affects daily work and beauty

Generally, oral medicine and surgical nail removal can be used to treat onychomycosis, but the cost of these treatments is high and the patients are suffering.

Antifungal ointment is the antifungal drug (miconazole nitrate cream; Terbinafine hydrochloride cream; Amorolfine hydrochloride cream) widely used at present, but its therapeutic effect is not ideal, the main reasons are as follows: 1. There are many kinds of pathogenic bacteria, and it is difficult to be effective against all pathogenic bacteria during the use of a single antibacterial component; 2. Some pathogenic bacteria have developed a certain degree of drug resistance; 3. The ointment is easy to wipe off, and the end time of the drug and the affected area short

There are patent reports using ciclopirox olamine and polymer materials to make a spray polymer antibacterial agent to prolong the action time of the affected area and drug molecules, but the polymer antibacterial agent is easy to release the drug from the film quickly when it encounters water and sweating. Leakage, resulting in unsatisfactory treatment effect

Images