Miconazole nitrate expandable vaginal suppository, and preparation method and detection method thereof

Abstract

The invention relates to a miconazole nitrate expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises a drug-containing matrix formed by miconazole nitrate and a matrix, and an expansion carrier. Miconazole nitrate and a specific solid dispersion carrier are prepared into a solid dispersion to improve the stability of the suppository and solubility of active ingredients, and increase bioavailability of the suppository. The outer layer of the expandable vaginal suppository is coated with a film coating to prolong the action time of the suppository on the vagina and improve the stability of the suppository. The miconazole nitrate expandable vaginal suppository provided by the invention employs seven originally created leading technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.

Description

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AI Technical Summary

Benefits of technology

This new version of this inventor's medicine uses special materials called expanders instead of traditional gels for delivering active ingredients into the uterus during medical procedures such as hysteroscopy surgery. These expanded carriers are designed to fit tightly around the inside walls of the patient’s cervix without causing pain when they come off their own hands. They act like isolated areas where only one part needs treatment while others still touch it. By increasing its size beyond 1% before use, any bacteria on these surfaces will stop growing but some may spread throughout them if needed again. Overall, this innovative technique helps improve the efficacy of treatments delivered via intrauterine devices.

Problems solved by technology

This patents describes different ways how drugs like micon azozepana amend Nitrone Sulphapy Neonil® may be taken internally without causing side effects. However, they often require long periods before being effective at treating diseases caused by harmful microorganisms called yeast mitochondria. To address this issue, researchers developed new formulations containing certain compounds known collectively as miconozonates, including MCDP-4897, LC-32106, MEK-18919, ML-2003, CE-177143, SM-5020, IM90318, SL-1049A, TM-3092, GE238182, HL6022, BCG-96152, THF-8705. These compositions were found promising because they could effectively deliver therapeutic agents through various routes like injection, nasal droplets, eye drop solutions, rectum foams, tablet dosings, capsules, and others.

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