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Compound miconazole nitrate composition for gynecology

A technology of miconazole nitrate and a composition is applied in the field of external compositions containing pentacyclic triterpenoids and miconazole nitrate, which can solve the problems such as the worsening of the treatment effect, and achieve the improvement of the bacteriostatic effect and the improvement of the treatment effect. effect, outstanding effect

Active Publication Date: 2019-03-22
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Miconazole Nitrate (Miconazole Nitrate, CAS: 22832-87-7) is a kind of antifungal drug, can be used for the treatment of mycotic vaginitis, but due to extensive use, cause Candida albicans to exist relatively to Miconazole Nitrate Strong drug resistance, leading to gradually worsening therapeutic effect

Method used

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  • Compound miconazole nitrate composition for gynecology
  • Compound miconazole nitrate composition for gynecology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Pharmacological Example 1, Preparation of drug-resistant strains

[0014] Preparation

[0015] 1) Candida albicans (Candida albicans) (Code: ATCC10231) was used as the standard strain, and the standard strain of Candida albicans was continuously transplanted twice on Sabouraud agar (SDA) medium (cultivation temperature 35°C), and cultivated for 24 hours Finally, select 5 bacterial colonies with a diameter greater than 1 cm and shake them in 5 mL sterile normal saline for 15 seconds to make a bacterial suspension. 5×10 5 CFU / mL.

[0016] 2) Detect the minimum inhibitory concentration (MIC) of miconazole nitrate to Candida albicans, carry out according to CLSIM38-2 scheme, quality control strain is Candida parapsilosis (ATCC 22019); MIC result to Candida albicans standard strain and Compared with the negative control group, the minimum concentration that can significantly inhibit the growth of fungi (about 80%) is the minimum inhibitory concentration

[0017] 3) Induc...

preparation Embodiment

[0041] In the preparation examples, the preparation is made into a gel, and the content specification of miconazole nitrate in all gels is unified as 200mg / 5g

[0042] Example 1

[0043] Miconazole Nitrate 40g, 23-Hydroxy Betulinic Acid 12g

[0044] Carbomer 940 15g, Glycerol 50g Tween 80 8g

[0045] Ethylparaben 1g triethanolamine to adjust the pH to 4.0-4.5 Add purified water to 1000g

[0046] Preparation method

[0047] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben g and the main ingredient and mixed to obtain a mixed solution 1)

[0048] 2) Mix glycerin and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 800g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .

Embodiment 2

[0050] Miconazole Nitrate 40g, 23-Hydroxy Betulinic Acid 16g

[0051] Carbomer 940 15g, Glycerol 50g Tween 80 8g

[0052] Ethylparaben 1g triethanolamine to adjust the pH to 4.0-4.5 Add purified water to 1000g

[0053] Preparation method

[0054] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben g and the main ingredient and mixed to obtain a mixed solution 1)

[0055] 2) Mix glycerin and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 800g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .

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Abstract

The invention discloses a compound miconazole nitrate composition for gynecology. The compound miconazole nitrate composition is characterized by being prepared from active ingredients of miconazole nitrate and 23-hydroxy betulinic acid as well as at least one ingredient for vaginal administration preparation; the mass ratio of the miconazole nitrate to the 23-hydroxy betulinic acid in the composition is 1 to (0.3 to 0.5). The composition is prepared into gel or suppository.

Description

Technical field: [0001] The invention provides a gynecological composition, especially an external composition containing pentacyclic triterpenoids and miconazole nitrate. Background technique: [0002] Mycotic vaginitis is a common and multiple vulvovaginal inflammatory disease caused by Candida. Candida albicans is an opportunistic pathogen. Generally, the amount of bacteria is small and does not cause symptoms. Only when the systemic and vaginal local immunity declines , especially the decline of local cellular immunity and the proliferation of Candida albicans will cause vaginitis symptoms. Miconazole Nitrate (Miconazole Nitrate, CAS: 22832-87-7) is a kind of antifungal drug, can be used for the treatment of mycotic vaginitis, but due to extensive use, cause Candida albicans to exist relatively to Miconazole Nitrate Strong drug resistance, leading to the gradual deterioration of its therapeutic effect. Therefore, how to improve the effect of miconazole nitrate preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/56A61P31/10A61P15/02
CPCA61K31/4174A61K31/56A61P15/02A61P31/10A61K2300/00
Inventor 李景
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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