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Miconazole nitrate compound vaginal effervescent tablets and preparation method thereof

A miconazole nitrate compound and technology of miconazole nitrate are applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of slow vaginitis effect and achieve good curative effect, low price, no Effects of Drug Dependence

Inactive Publication Date: 2015-12-02
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when miconazole nitrate is used alone to treat vaginitis, the symptoms of vaginitis caused by fungi are slow.

Method used

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  • Miconazole nitrate compound vaginal effervescent tablets and preparation method thereof
  • Miconazole nitrate compound vaginal effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound vaginal effervescent tablet of miconazole nitrate. The components and parts by weight of the effervescent tablet include: 1 part of miconazole nitrate, 20 parts of Corydalis nicotine, 15 parts of mountain cucumber, 40 parts of Sophora flavescens, and 35 parts of catechu , 60 parts of half leaves, 30 parts of nine grasses, 30 parts of white fresh skin, 35 parts of Polygonum multiflorum, 50 parts of mugwort leaves, 5 parts of tartaric acid, 3 parts of sodium carbonate, 4 parts of sodium bicarbonate, 1 part of sodium lauryl sulfate, 5 parts of dextrin, 0.5 parts of polysorbate.

[0039] A preparation method of miconazole nitrate compound vaginal effervescent tablet, comprising the following steps:

[0040] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, tartaric acid, sodium carbonate, sodium bicarbonate, sodium lauryl sulfate, dextrin, and polysorbate a...

Embodiment 2

[0050] A compound vaginal effervescent tablet of miconazole nitrate. The components and parts by weight of the effervescent tablet include: 2 parts of miconazole nitrate, 22 parts of Corydalis nicotine, 18 parts of mountain cucumber, 43 parts of Sophora flavescens, and 37 parts of catechu , 65 parts of half leaves, 35 parts of nine grasses, 38 parts of white fresh skin, 36 parts of Polygonum multiflorum, 57 parts of mugwort leaves, 8 parts of tartaric acid, 4 parts of sodium carbonate, 9 parts of sodium bicarbonate, 1.6 parts of sodium lauryl sulfate, 8 parts of dextrin, 0.7 parts of polysorbate.

[0051] A preparation method of miconazole nitrate compound vaginal effervescent tablet, comprising the following steps:

[0052] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, tartaric acid, sodium carbonate, sodium bicarbonate, sodium lauryl sulfate, dextrin, and polysorba...

Embodiment 3

[0062] A compound vaginal effervescent tablet of miconazole nitrate, the components and parts by weight of the effervescent tablet include: 3 parts of miconazole nitrate, 25 parts of Corydalis Corydalis, 20 parts of mountain cucumber, 45 parts of Sophora flavescens, and 40 parts of catechu , 70 parts of half leaves, 40 parts of Hydra, 40 parts of white fresh skin, 40 parts of Polygonum multiflorum, 60 parts of mugwort leaves, 10 parts of tartaric acid, 5 parts of sodium carbonate, 10 parts of sodium bicarbonate, 2 parts of sodium lauryl sulfate, 10 parts of dextrin, 1 part of polysorbate.

[0063] A preparation method of miconazole nitrate compound vaginal effervescent tablet, comprising the following steps:

[0064] 1) Prepare materials, prepare materials according to the described components and parts by weight, miconazole nitrate is pulverized through a 120 mesh sieve, tartaric acid, sodium carbonate, sodium bicarbonate, sodium lauryl sulfate, dextrin, and polysorbate are p...

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Abstract

The invention discloses miconazole nitrate compound vaginal effervescent tablets and a preparation method thereof. The effervescent tablets comprise miconazole nitrate, Corydalis tuber, Tricyrtis root, lightyellow Sophora root, cutch, herb of Wilson Passionflower, radix Silene tenuis, root-bark of shaggy-fruited dittany, fleeceflower root, Chinese mugwort leaf, tartaric acid, sodium carbonate, sodium bicarbonate, lauryl sodium sulfate, dextrin, and polysorbate. The preparation method includes: preparing materials, extracting effective ingredients of herbal materials, and performing granulating and tableting. The miconazole nitrate compound vaginal effervescent tablets are a Chinese and western medicine mixture, the defect that miconazole nitrate is only capable of killing germs and diminishing inflammation is effectively overcome, and the herbs are good in synergistic effect. The tablets directly act on an affected part, take effect fast, are good in effect and are convenient to use; after the effervescent tablets effervesce, a larger contact area between medicine and the human body is provided; drug effect is improved. The tablets are capable of treating both symptoms and root causes of vaginitis, quickly relieving pain and pruritus symptoms of a patient, restoring vaginal secretion and improving patient compliance.

Description

technical field [0001] The invention belongs to the field of topical medication, and specifically relates to a miconazole nitrate compound vaginal effervescent tablet and a preparation method thereof. Background technique [0002] Vaginitis is the most common infectious disease in women. Its common symptoms are increased vaginal discharge, genital itching and burning pain, which may be accompanied by frequent urination, dysuria and dyspareunia. Gynecological examination showed increased vaginal discharge, vaginal mucosa hyperemia or scattered bleeding spots, a large amount of leucorrhea in the posterior fornix of the vagina, gray-yellow or yellow-green purulent discharge, sometimes foamy or white thick curd or bean dregs. Edema, scratches, and geographic erythema were seen on the vulva. [0003] Vaginal mucosal administration has a history of nearly a hundred years, and it has many advantages compared with traditional oral administration. It can be used not only locally, bu...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/46A61P15/02A61P31/02A61P29/00A61P17/04A61K31/194A61K31/4174A61K33/00
Inventor 袁国防周丽萍王小雅孙彦龙
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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