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Metronidazole and miconazole nitrate compound vaginal effervescent tablet and method for preparing same

A metronidazole and miconazole nitrate compound and miconazole nitrate technology, which is applied in the field of metronidazole and miconazole nitrate compound vaginal effervescent tablets and its preparation, can solve the problems of slow effective effect, achieve rapid onset of effect, and relieve redness and swelling , Improve the effect of bactericidal / antibacterial spectrum

Inactive Publication Date: 2015-12-02
QINGDAO HAIZHIYUAN INTELLIGENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when metronidazole and miconazole nitrate are used alone to treat vaginitis, the symptoms of vaginitis caused by fungi are slow to take effect.

Method used

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  • Metronidazole and miconazole nitrate compound vaginal effervescent tablet and method for preparing same
  • Metronidazole and miconazole nitrate compound vaginal effervescent tablet and method for preparing same
  • Metronidazole and miconazole nitrate compound vaginal effervescent tablet and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound vaginal effervescent tablet of metronidazole and miconazole nitrate. The components and parts by weight of the effervescent tablet include: 5 parts of metronidazole, 8 parts of miconazole nitrate, 25 parts of Corydalis Corydalis, 45 parts of catechu, 35 parts of white fish tail, 35 parts of Hydrangea, 50 parts of Polygonum multiflorum, 25 parts of purslane, 50 parts of dog ant grass, 35 parts of roasted licorice, 15 parts of Angelica dahurica, 8 parts of cicada slough, 10 parts of citric acid, 5 parts of sodium bicarbonate 5 parts, potassium carbonate 5 parts, polyethylene glycol 60001 parts, dextrin 10 parts, Tween-800.5 parts, low-substituted hydroxypropyl cellulose 10 parts.

[0039] A kind of preparation method of metronidazole nitrate miconazole compound vaginal effervescent tablet, comprises the following steps:

[0040] 1) prepare raw materials, prepare raw materials according to the component and parts by weight of a kind of metronidazole and miconazo...

Embodiment 2

[0046] A compound vaginal effervescent tablet of metronidazole and miconazole nitrate. The components and parts by weight of the effervescent tablet include: 10 parts of metronidazole, 12 parts of miconazole nitrate, 30 parts of Corydalis Corydalis, 50 parts of catechu, 40 parts of white fish tail, 40 parts of nine heads of grass, 55 parts of Polygonum multiflorum, 30 parts of purslane, 55 parts of dog ant grass, 40 parts of roasted licorice, 20 parts of Angelica dahurica, 12 parts of cicada slough, 15 parts of citric acid, 8 parts of sodium bicarbonate 8 parts, potassium carbonate 8 parts, polyethylene glycol 60002 parts, dextrin 15 parts, Tween-800.8 parts, low-substituted hydroxypropyl cellulose 15 parts.

[0047] A kind of preparation method of metronidazole nitrate miconazole compound vaginal effervescent tablet, comprises the following steps:

[0048] 1) prepare raw materials, prepare raw materials according to the component and parts by weight of a kind of metronidazole...

Embodiment 3

[0054] A compound vaginal effervescent tablet of metronidazole and miconazole nitrate. The components and parts by weight of the effervescent tablet include: 7 parts of metronidazole, 11 parts of miconazole nitrate, 28 parts of Corydalis Corydalis, 47 parts of catechu, 39 parts of white fish tail, 36 parts of Hydrangea, 53 parts of Polygonum multiflorum, 27 parts of purslane, 51 parts of dog ant grass, 37 parts of roasted licorice, 18 parts of Angelica dahurica, 11 parts of cicada slough, 12 parts of citric acid, 7 parts of sodium bicarbonate 6 parts, 6 parts of potassium carbonate, 1.3 parts of polyethylene glycol 60000, 11 parts of dextrin, 0.7 parts of Tween-800, 14 parts of low-substituted hydroxypropyl cellulose.

[0055] A kind of preparation method of metronidazole nitrate miconazole compound vaginal effervescent tablet, comprises the following steps:

[0056] 1) prepare raw materials, prepare raw materials according to the component and parts by weight of a kind of met...

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Abstract

The invention discloses a metronidazole and miconazole nitrate compound vaginal effervescent tablet and a method for preparing the same. The effervescent tablet comprises metronidazole, miconazole nitrate, rhizoma corydalis, acacia catechu, Asian butteflybush roots and leaves, dicliptera chinensis, polygonum multiflorum, herba portulacae, alysicarpus vaginalis, prepared licorice, angelica dahurica, cicada slough, citric acid, sodium bicarbonate, potassium carbonate, polypropylene glycol 6000, dextrin, tween-80 and low-substituted hydroxypropyl cellulose. The method includes preparing materials; extracting effective components of crude traditional Chinese medicines; granulating the effective components; compressing the effective components to obtain the tablet. The metronidazole and miconazole nitrate compound vaginal effervescent tablet and the method have the advantages that the effervescent tablet is a Chinese-western medicine mixture, antibacterial / inhibition spectra can be broadened, shortcomings of pure western medicine and the shortcoming of inconvenience in carrying and storing washing liquor can be overcome, the metronidazole and miconazole nitrate compound vaginal effervescent tablet can directly act on affected parts of patients by the aid of a process for locally treating vaginitis in an external application manner, obvious synergistic effects can be realized by the medicines, the metronidazole and miconazole nitrate compound vaginal effervescent tablet can become effective fast, and good curative effects can be realized.

Description

technical field [0001] The invention belongs to the field of topical external medicine, and specifically relates to a compound vaginal effervescent tablet of metronidazole nitrate and miconazole and a preparation method thereof. Background technique [0002] Vaginitis is the most common infectious disease in women. Its common symptoms are increased vaginal discharge, genital itching and burning pain, which may be accompanied by frequent urination, dysuria and dyspareunia. Gynecological examination showed increased vaginal discharge, vaginal mucosa hyperemia or scattered bleeding spots, a large amount of leucorrhea in the posterior fornix of the vagina, gray-yellow or yellow-green purulent discharge, sometimes foamy or white thick curd or bean dregs. Edema, scratches, and geographic erythema were seen on the vulva. [0003] Vaginal mucosal administration has a history of nearly a hundred years, and it has many advantages compared with traditional oral administration. It can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/46A61P15/02A61P31/10A61K31/4164A61K31/4174A61K35/64A61K33/00
Inventor 袁国防周丽萍王小雅孙彦龙
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
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