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Anti-inflammatory and antibacterial onychomycosis treating gel agent and preparation method thereof

An anti-inflammatory, anti-bacterial, onychomycosis technology, applied in the direction of antifungal agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of high recurrence rate, affecting patients' daily work and life, etc.

Active Publication Date: 2017-12-22
WANNAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The probability of recurrence after treatment is high, and during the treatment period, the nails need to be scraped continuously, applied with medicine and then bandaged, which seriously affects the daily work and life of the patient.

Method used

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  • Anti-inflammatory and antibacterial onychomycosis treating gel agent and preparation method thereof
  • Anti-inflammatory and antibacterial onychomycosis treating gel agent and preparation method thereof
  • Anti-inflammatory and antibacterial onychomycosis treating gel agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A gel for anti-inflammatory and antibacterial treatment of onychomycosis, comprising the following raw material components:

[0057]

[0058]

[0059] 1.1 Preparation of garlic extract

[0060] Weigh 50g of garlic, mash it, soak for 0.4h, heat and reflux for extraction 3 times: add 18 times the amount of water for the first time, extract for 1.0h; add 12 times the amount of water for the second time, extract for 1.0h; add 8 times for the third time Measure water, extract for 0.5h, and filter each time to obtain the filtrate, combine the filtrates, concentrate the volume of the filtrate to 3 times the mass of garlic g / mL, and filter to obtain.

[0061] 1.2 Preparation of Sophora flavescens extract

[0062] Weigh 45g of Sophora flavescens coarse powder, soak for 0.5h, heat and reflux extraction for 3 times: add 16 times the amount of 75% ethanol for the first time, extract for 1.5h; add 12 times the amount of 75% ethanol for the second time, extract for 1.0h; Add ...

Embodiment 2

[0085] A gel for anti-inflammatory and antibacterial treatment of onychomycosis, comprising the following raw material components:

[0086]

[0087]

[0088] 2.1 Preparation of garlic extract

[0089] Weigh 40g of garlic, mash it, soak it for 0.6h, heat and reflux for extraction 3 times: add 18 times the amount of water for the first time, extract for 1.5 hours; add 16 times the amount of water for the second time, extract for 1.5 hours; add 10 times the amount for the third time Measure water, extract for 1.0h, and filter each time to obtain the filtrate, combine the filtrates, concentrate the volume of the filtrate to 4 times the mass of garlic g / mL, and filter to obtain.

[0090] 2.2 Preparation of Sophora flavescens extract

[0091]Weigh 35g of Sophora flavescens coarse powder, soak for 0.8h, heat and reflux for extraction 3 times: add 16 times the amount of 75% ethanol for the first time, extract for 1.5 hours; add 12 times the amount of 75% ethanol for the second ...

Embodiment 3

[0114] A gel for anti-inflammatory and antibacterial treatment of onychomycosis, comprising the following raw material components:

[0115]

[0116]

[0117] 3.1 Preparation of garlic extract

[0118] Weigh 40g of garlic, mash it, soak for 0.8h, heat and reflux for extraction 3 times: add 20 times the amount of water for the first time, extract for 2.0 hours; add 18 times the amount of water for the second time, extract for 2.0 hours; add 12 times for the third time Measure the water, extract for 1.0h, and filter each time to obtain the filtrate, combine the filtrates, concentrate the volume of the filtrate to 5 times the mass of garlic g / mL, and filter to obtain.

[0119] 3.2 Preparation of Sophora flavescens extract

[0120] Weigh 30g of Sophora flavescens coarse powder, soak for 1.0h, heat and reflux for extraction 3 times: add 18 times the amount of 75% ethanol for the first time, extract for 2.0 hours; add 14 times the amount of 75% ethanol for the second time, ext...

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Abstract

The invention provides an anti-inflammatory and antibacterial onychomycosis treating gel agent and a preparation method thereof. The gel agent contains the following substances: hydroxypropylmethyl cellulose, sodium carboxymethyl cellulose, glycerin, azone, miconazole nitrate, aloe oil, sea buckthorn fruit oil, white vinegar, a garlic extract, a sophora flavescens extract, a phryma leptostachya extract, a pepper extract, a stemona japonica extract, a folium artemisiae argyi extract, a kochia scoparia fruit extract, an impatiens balsamina extract, distilled water, ethanol with the concentration of 75%, urea, methylparaben and ethylparaben. Compared with the prior art, the gel agent provided by the invention has the advantages of quick absorption, good compliance, an exact effect of preventing and treating onychomycosis, efficacies of eliminating inflammation, resisting bacteria, improving the textures and colors of nails, treating beriberi and the like, and capabilities of significantly improving the onychomycosis of a patient and effectively improving the immunity.

Description

technical field [0001] The invention relates to a gel, in particular to an anti-inflammatory and antibacterial gel for treating onychomycosis and a preparation method thereof. Background technique [0002] Onychomycosis is nail or toenail infection caused by pathogenic fungi such as dermatophytes, yeasts and non-dermatophytes. Fungal infection caused by scratching is the most common cause of onychomycosis. For example, patients with athlete's foot or jock itch often scratch their fingernails due to unbearable itching, so that many pathogenic fungi will be stained on the fingernails, and the fungi will Taking advantage of the situation, it invades the skin around the nail or toenail, and gradually enters the deck through the growth and evolution of the nail or toenail, and further grows and reproduces until the entire deck is destroyed, forming onychomycosis. The nails of onychomycosis patients are characterized by abnormal nail color and shape. The nail plate loses luster a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/06A61K47/38A61K47/22A61K47/10A61P17/00A61P31/10A61K31/4174A61K31/19A61K31/17
CPCA61K9/0014A61K9/06A61K31/17A61K31/19A61K31/4174A61K36/185A61K36/282A61K36/47A61K36/489A61K36/758A61K36/886A61K36/896A61K36/8962A61K36/904A61K47/10A61K47/22A61K47/38A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 孙淑萍李苹苹居世杰殷传刘谢东余配全孔孟美
Owner WANNAN MEDICAL COLLEGE
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