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Anti-infectious medical silicon rubber material and preparation method thereof

A silicone rubber, anti-infection technology, applied in the field of medical materials, can solve problems such as affecting the treatment effect and microbial infection, and achieve the effect of excellent bacteriostatic function, infection prevention, and obvious anti-infection effect.

Inactive Publication Date: 2015-09-23
SUZHOU JONATHAN NEW MATERIALS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because polymer materials inevitably contain substances that can be used as microbial nutrition materials, microorganisms in the surrounding environment are easy to adhere to the surface of polymer medical devices during use, and then colonize and multiply. The human body is likely to cause microbial infection and affect treatment. Effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] An anti-infective medical silicone rubber material is composed of the following components in parts by mass: 56 parts of solid silicone rubber particles, 3 parts of butyl oleate, 11 parts of polyethylene wax, 2 parts of polyvinylpyrrolidone, 5 parts of miconazole nitrate parts, 13 parts of trilaurylamine, 5 parts of diammonium hydrogen phosphate, 3 parts of antioxidant 1010.

[0018] Preparation:

[0019] (1) According to the above mass parts, pulverize the solid silicone rubber particles, add butyl oleate, polyethylene wax, polyvinyl pyrrolidone, diammonium hydrogen phosphate and antioxidant 1010, heat to 100 ° C, stir evenly, and obtain a mixture one;

[0020] (2) The first mixture obtained in step (1) is placed in a cobalt 60 irradiation field for irradiation, and then miconazole nitrate and trilaurylamine are added, and the second mixture is obtained after ultrasonication for 10 minutes;

[0021] (3) The second mixture obtained in step (2) is placed in an internal...

Embodiment 2

[0023] An anti-infective medical silicone rubber material is composed of the following components in parts by mass: 73 parts of solid silicone rubber particles, 14 parts of butyl oleate, 19 parts of polyethylene wax, 8 parts of polyvinylpyrrolidone, and 17 parts of miconazole nitrate. parts, 24 parts of trilaurylamine, 22 parts of diammonium hydrogen phosphate, 17 parts of antioxidant 1010.

[0024] Preparation:

[0025] (1) According to the above mass parts, pulverize the solid silicone rubber particles, add butyl oleate, polyethylene wax, polyvinyl pyrrolidone, diammonium hydrogen phosphate and antioxidant 1010, heat to 130 ° C, stir evenly, and obtain a mixture one;

[0026] (2) placing the first mixture obtained in step (1) in a cobalt 60 irradiation field for irradiation, then adding miconazole nitrate and trilaurylamine, and ultrasonicating for 20 minutes to obtain the second mixture;

[0027] (3) Putting the second mixture obtained in step (2) into a 230°C internal mi...

Embodiment 3

[0029] An anti-infective medical silicone rubber material is composed of the following components in parts by mass: 59 parts of solid silicone rubber particles, 5 parts of butyl oleate, 13 parts of polyethylene wax, 3 parts of polyvinylpyrrolidone, and 9 parts of miconazole nitrate. parts, 16 parts of trilaurylamine, 12 parts of diammonium hydrogen phosphate, 8 parts of antioxidant 1076.

[0030] Preparation:

[0031] (1) According to the above mass parts, pulverize the solid silicone rubber particles, add butyl oleate, polyethylene wax, polyvinyl pyrrolidone, diammonium hydrogen phosphate and antioxidant 1076, heat to 110 ° C, stir evenly, and obtain a mixture one;

[0032] (2) The first mixture obtained in step (1) is placed in a cobalt 60 irradiation field for irradiation, then miconazole nitrate and trilaurylamine are added, and the second mixture is obtained after ultrasonication for 12 minutes;

[0033] (3) The second mixture obtained in step (2) is placed in an intern...

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PUM

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Abstract

The invention discloses an anti-infectious medical silicon rubber material and a preparation method thereof. The anti-infectious medical silicon rubber material comprises the following components by mass: 56-73 parts of solid silicone rubber particles, 3-14 parts of butyl oleate, 11-19 parts of polyethylene wax, 2-8 parts of polyvinylpyrrolidone, 5-17 parts of miconazole nitrate, 13-24 parts of tridodecylamine, 5-22 parts of diammonium hydrogen phosphate, and 3-17 parts of an antioxygen. The silicon rubber material, prepared according to the preparation method, has an excellent antibacterial effect, can prevent infection, and has an important function in clinic treatment.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to an anti-infective medical silicone rubber material and a preparation method thereof. Background technique [0002] Silicone rubber refers to the rubber whose main chain is composed of alternating silicon and oxygen atoms, and two organic groups are usually connected to the silicon atom. Ordinary silicone rubber is mainly composed of silicone chain units containing methyl groups and a small amount of vinyl groups. [0003] Silicone rubber has the following advantages: (1) Good low temperature resistance, generally can still work at -55 °C; (2) Outstanding heat resistance, can work for a long time at 180 °C, and can withstand several weeks at slightly higher than 200 °C It is still elastic for a long time, and can withstand high temperatures above 300 °C in an instant; (3) It has good air permeability, and the oxygen transmission rate is the highest among synthetic polymers; (4) I...

Claims

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Application Information

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IPC IPC(8): C08L83/04C08L23/06C08L39/06C08K5/00C08K5/3445C08K5/17C08K3/32
Inventor 吕少波李卓才李苏杨
Owner SUZHOU JONATHAN NEW MATERIALS TECH
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