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A kind of gel containing antifungal drug and preparation method thereof

A technology for antifungal drugs and gels, applied in the directions of antifungal agents, medical preparations containing active ingredients, drug delivery, etc. and other problems, to achieve a good slow release effect, improve bioavailability, and long retention time.

Inactive Publication Date: 2011-11-30
邹巧根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The dosage forms of fenticonazole nitrate listed abroad include cream, lotion, aerosol and soft gelatin vaginal suppository, wherein the residence time of lotion and aerosol in the lesion is short; the active agents in cream and ointment are mostly in a dispersed state, It is not easy to fully exert the drug effect, and it is difficult to clean after use; suppositories are suitable for oral drug administration, but they cannot fully contact the epidermis or mucous membrane of the lesion, and it is not easy to fully exert the drug effect

Method used

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  • A kind of gel containing antifungal drug and preparation method thereof
  • A kind of gel containing antifungal drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription

[0020] Fenticonazole Nitrate 20g

[0021] Glycerin 200g

[0022] Propylene glycol 300g

[0023] Ethanol 60g

[0024] Purified water 235g

[0025] Poloxamer 407 180g

[0026] Sodium Benzoate 5g

[0027] Edetate Disodium 0.5g

[0028]

[0029] Made into 1000g

[0030] Preparation Process

[0031] Heat fenticonazole nitrate, 1 / 2 amount of poloxamer 407, ethanol and glycerin at 60°C to completely dissolve and mix well; dissolve sodium benzoate and edetate disodium in purified water, add 1 / 2 A certain amount of poloxamer 407 and propylene glycol are completely dissolved at 0-5°C and mixed uniformly; the above two solutions are mixed uniformly to obtain the product.

Embodiment 2

[0033] prescription

[0034] Fenticonazole Nitrate 20g

[0035] Poloxamer 407 170g

[0036] Carbomer 10g

[0037] Glycerin 200g

[0038] Propylene glycol 300g

[0039] Purified water 235g

[0040] Ethanol 60g

[0041] Sodium Benzoate 5g

[0042] Edetate Disodium 0.5g

[0043]

[0044] Made into 1000g

[0045] Preparation Process

[0046] Heat fenticonazole nitrate, poloxamer 407, ethanol and glycerin at 60°C to dissolve completely and mix well; dissolve sodium benzoate and disodium edetate in purified water, add carbomer and propylene glycol to the above Fully dissolve / or swell in the solution and mix uniformly; mix the above two solutions uniformly to obtain.

Embodiment 3

[0048] prescription

[0049] Fenticonazole Nitrate 20g

[0050] Poloxamer 407 170g

[0051] Carbomer 5g

[0052] Glycerin 200g

[0053] Propylene glycol 300g

[0054] Purified water 240g

[0055] Ethanol 60g

[0056] Sodium Benzoate 5g

[0057] Edetate Disodium 0.5g

[0058]

[0059] Made into 1000g

[0060] Preparation Process

[0061] Heat fenticonazole nitrate, poloxamer 407, ethanol and glycerin at 60°C to dissolve completely and mix well; dissolve sodium benzoate and disodium edetate in purified water, add carbomer and propylene glycol to the above Fully dissolve / or swell in the solution and mix uniformly; mix the above two solutions uniformly to obtain.

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PUM

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Abstract

The invention relates to a gel containing antifungal drugs for treating fungal infections in different parts of the body and related skin ringworm and inflammation and a preparation method thereof. The gel is composed of 0.1%-20% by weight of fenticonazole nitrate, 0.1%-30% of polymer, 5%-95% of solvent, and 0%-30% of other pharmaceutically acceptable auxiliary materials . The gel agent of the present invention has the advantages of good visual effect, simple preparation process, convenient application, easy cleaning after use, full contact with the epidermis or mucous membrane of the drug administration site, long retention time, and the advantages of being convenient for fully exerting the drug effect and the like.

Description

technical field [0001] The invention relates to a gel containing antifungal drugs for treating fungal infections in different parts of the body and related skin ringworm and inflammation caused by them, and a preparation method of the gel. Background technique [0002] Imidazole drugs are mainly applicable to skin mildews (alopecia tinea, ringworm, jock itch, athlete's foot) caused by dermatophytes (all types of trichophyton, microphyton and epidermophyton). Ringworm, tinea manuum, tinea face, tinea manuum, onychomycosis), candida infection, candida infection of genital organs (vaginal candida infection and scrotum candida infection), anal intertrigo, candidal angular sores, nail bed inflammation And paronychia etc. [0003] At present, the first-line drugs for the treatment of candidiasis in China are yiconazole and clotrimazole, etc. Fenticonazole nitrate has excellent antibacterial activity against all Gram-positive cocci and bacilli, and is higher than miconazole and tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/08A61K31/4174A61P17/00A61P31/10
Inventor 邹巧根
Owner 邹巧根
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