External traditional Chinese medicine composition for treating cold-heat mixed type diseases

Abstract

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical Chinese medicine composition for treating diseases with mixed cold and heat patterns. Background Technology

[0002] The mixed cold and heat syndrome is a common complex syndrome in TCM clinical practice. It is based on yang deficiency, with cold, dampness, heat and toxicity as the manifestations. The cold and heat are mixed, and phlegm and blood stasis are intertwined, manifesting as problems such as pain, swelling, limited mobility, and functional impairment. It is commonly seen in diseases such as rheumatoid bone disease, traumatic injuries, burns, and prostatitis.

[0003] Currently, traditional Chinese medicine (TCM) external preparations for these diseases have several problems: imbalanced cold and heat properties, leading to strong side effects. For example, while Musk Wind-Dispelling and Pain-Relieving Plaster can warm and unblock meridians, its pungent and hot nature can easily cause dryness and damage to Yin, potentially causing adverse reactions such as dry mouth, dry skin, etc. Furthermore, its efficacy is limited, and its application is narrow. For instance, Yunnan Baiyao aerosol is mainly used for traumatic injuries, possessing the effects of promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain, but its effect on cold-dampness arthralgia in rheumatoid arthritis is limited. Therefore, it is essential to develop a balanced, safe, multi-target, broad-spectrum TCM external preparation. Summary of the Invention

[0004] The purpose of this invention is to overcome the problems of large side effects and single efficacy of existing external Chinese medicine preparations for treating diseases with mixed cold and heat patterns, and to provide an external Chinese medicine composition that balances cold and heat, has high safety, and has multi-target and broad-spectrum therapeutic effects.

[0005] The technical solution adopted by the present invention to solve its technical problem is: a topical Chinese medicine composition for treating diseases with mixed cold and heat patterns, characterized in that it is composed of the following Chinese medicine raw materials in the following weight ratios: Aconitum carmichaelii 4-5 parts, Clematis chinensis 4-5 parts, Rheum palmatum 4-5 parts, Clematis armandii 2-3 parts, Boswellia carterii 2-3 parts, Commiphora myrrha 2-3 parts, Asarum heterotropoides 2-3 parts, Arisaema heterophyllum 2-3 parts, Zingiber officinale 2-3 parts, Taraxacum mongolicum 2-3 parts, and Luffa cylindrica 2-3 parts.

[0006] Optionally, the traditional Chinese medicine composition consists of the following traditional Chinese medicine raw materials in the indicated weight ratios: 4.5 parts Aconitum carmichaelii, 4.5 parts Clematis chinensis, 4.5 parts Rheum palmatum, 2.5 parts Clematis chinensis, 2.5 parts Boswellia carterii, 2.5 parts Commiphora myrrha, 2.5 parts Asarum heterotropoides, 2.5 parts Arisaema heterophyllum, 2.5 parts Zingiber officinale, 2.5 parts Taraxacum mongolicum, and 2.5 parts Luffa cylindrica.

[0007] Optionally, the traditional Chinese medicine composition consists of the following traditional Chinese medicine raw materials in the indicated weight ratios: 5 parts Aconitum carmichaelii, 5 parts Clematis chinensis, 4 parts Rheum palmatum, 3 parts Clematis chinensis, 2 parts Boswellia carterii, 2 parts Commiphora myrrha, 3 parts Asarum heterotropoides, 3 parts Arisaema heterophyllum, 3 parts Zingiber officinale, 3 parts Taraxacum mongolicum, and 3 parts Luffa cylindrica.

[0008] Optionally, the traditional Chinese medicine composition is composed of traditional Chinese medicine raw materials in the following weight ratios: 4 parts of aconite root, 4 parts of speranskia tuberculata, 5 parts of rhubarb, 2 parts of clematis chinensis, 3 parts of frankincense, 3 parts of myrrh, 2 parts of asarum, 2 parts of raw arisaema consanguineum, 2 parts of ginger, 2 parts of dandelion, and 2 parts of luffa cylindrica.

[0009] Optionally, the dosage form of the traditional Chinese medicine composition is an external liquid preparation, an external ointment, an external gel, an external spray or an external patch.

[0010] Optionally, the preparation method of the liniment of the traditional Chinese medicine composition is: weighing the traditional Chinese medicine raw materials according to the weight ratio, mixing them and placing them in a sealed container, adding 50%-70% ethanol, and the dosage of ethanol is 5-10 times the total weight of the medicinal materials, soaking at room temperature or in a cool place for 15-30 days, filtering to remove the medicinal residues, collecting the filtrate, and preparing it into a liniment.

[0011] The properties and flavors of each traditional Chinese medicine raw material in this traditional Chinese medicine composition are as follows: Aconite root is extremely hot in nature, pungent and sweet in flavor, and belongs to the heart, kidney, and spleen meridians, with the effects of rescuing yang from collapse, tonifying fire and assisting yang, and dispelling cold and relieving pain; Speranskia tuberculata is warm in nature, pungent in flavor, and belongs to the liver and kidney meridians, with the effects of dispelling wind and dampness, relaxing tendons and activating collaterals, and dissipating stasis and relieving swelling; Rhubarb is cold in nature, bitter in flavor, and belongs to the spleen, stomach, and large intestine meridians, with the effects of purging accumulation and stagnation, clearing damp-heat, purging fire and detoxifying, cooling blood and dissipating stasis, and removing blood stasis and dredging menstruation; Clematis chinensis is warm in nature, pungent and bitter in flavor, and belongs to the bladder meridian, with the effects of dispelling wind and dampness and dredging collaterals and relieving pain; Frankincense is neutral in nature, pungent and bitter in flavor, and belongs to the liver, heart, and spleen meridians, with the effects of promoting blood circulation and regulating qi to relieve pain and promoting tissue regeneration and relieving swelling; Myrrh is neutral in nature, pungent and bitter in flavor, and belongs to the liver, spleen, heart, and kidney meridians, with the effects of dispersing blood stasis and relieving swelling and alleviating pain; Asarum is warm in nature, pungent in flavor, and belongs to the heart, lung, and kidney meridians, with the effects of dispelling wind and cold, dispelling wind and relieving pain, opening the nasal passage, and warming the lung and resolving fluid-retention; Raw arisaema consanguineum is warm in nature, pungent and bitter in flavor, and belongs to the lung, liver, and spleen meridians, with the effect of dissipating stasis and relieving swelling; Ginger is warm in nature, pungent in flavor, and belongs to the lung, spleen, and stomach meridians, with the effects of inducing sweating to dispel cold, warming the middle-jiao to arrest vomiting, and resolving phlegm and relieving cough; Dandelion is cold in nature, sweet and bitter in flavor, and belongs to the liver and stomach meridians, with the effects of clearing heat and detoxifying, dissipating stasis and relieving swelling, and inducing diuresis for treating stranguria; Luffa cylindrica is neutral in nature, sweet in flavor, and belongs to the lung, liver, and stomach meridians, with the effects of dispelling wind and dredging collaterals, promoting blood circulation, and promoting lactation.

[0012] The compatibility structure of this traditional Chinese medicine composition: Aconite root, speranskia tuberculata, and rhubarb are all monarch drugs. The three drugs are compatible, warm without being dry and cold without being stagnant, forming a comprehensive compatibility of "warming yang + promoting blood circulation + clearing heat"; Clematis chinensis, frankincense, myrrh, asarum, and raw arisaema consanguineum are the ministerial drugs, assisting the monarch drugs to enhance the efficacy, forming a synergistic compatibility of "dredging collaterals + promoting blood circulation + dissipating stasis"; Ginger and dandelion are the adjuvant drugs, with multiple functions, forming an auxiliary compatibility of "detoxifying + harmonizing"; Luffa cylindrica is the envoy drug, harmonizing all the drugs and guiding the medicinal properties to reach the affected area directly.

[0013] The compatibility theory of this traditional Chinese medicine composition: 1. Preserving the efficacy while eliminating the properties: Rhubarb is bitter and cold. When it is compatible with warm drugs such as aconite root and asarum, its cold nature is restricted, and the effects of promoting blood circulation to remove blood stasis and clearing heat and detoxifying are retained. 2. Synergistic Relationship: Frankincense and myrrh enhance the effects of promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain; Aconitum carmichaelii and Clematis chinensis enhance the effects of warming yang, dispelling cold, unblocking meridians, and relieving pain; Rhubarb and dandelion enhance the effects of clearing heat, detoxifying, cooling blood, and removing blood stasis. 3. Mutual Enhancement Relationship: Aconite and ginger: ginger counteracts the toxicity of aconite while enhancing its warming effect; rhubarb and asarum: ginger enhances the blood-activating and meridian-clearing effect of rhubarb while counteracting its cold nature; raw arisaema and ginger: ginger counteracts the toxicity of raw arisaema while enhancing its effects of dispersing nodules and reducing swelling. 4. Mutual restraint and antagonism: Raw Arisaema and ginger can restrain and neutralize the toxicity of raw Arisaema, ensuring the safety of medication.

[0014] Compared with the prior art, the present invention has at least the following beneficial effects: The present invention uses both cold and hot methods to harmonize yin and yang. It treats superficial symptoms by tonifying yang to regulate the root cause, softening and dispersing nodules, promoting blood circulation and removing blood stasis, and dispelling wind and relieving pain. It also uses methods to remove necrotic tissue and promote tissue regeneration to regulate and restore the body. This results in a multi-target, broad-spectrum therapeutic effect, which is mainly used to treat diseases with mixed cold and heat patterns. It can effectively treat or alleviate diseases such as rheumatoid bone disease, traumatic injuries, burns, and prostatitis. Detailed Implementation

[0015] Example 1: A topical Chinese medicine composition for treating a mixed cold and heat syndrome, comprising the following Chinese medicinal materials in the indicated weight ratios: Aconitum carmichaelii 4.5 parts, Clematis chinensis 4.5 parts, Rheum palmatum 4.5 parts, Clematis armandii 2.5 parts, Boswellia carterii 2.5 parts, Commiphora myrrha 2.5 parts, Asarum heterotropoides 2.5 parts, Arisaema heterophyllum 2.5 parts, Zingiber officinale 2.5 parts, Taraxacum mongolicum 2.5 parts, Luffa cylindrica 2.5 parts; Preparation method of liniment: Prepare Aconitum carmichaelii (select salted Aconitum carmichaelii, soak in water until the salt is removed, and boil with licorice and black beans until there is no numbness on the tongue), Clematis chinensis (dried whole herb), rhubarb (raw rhubarb), Clematis armandii (dried root and rhizome), frankincense (dried resin), myrrh (dried resin), Asarum heterotropoides (dried root and rhizome), raw Arisaema heterophyllum (dried tuber), ginger (fresh rhizome), dandelion (dried whole herb), and loofah sponge (vascular bundles of dried mature fruit). Weigh the Chinese herbal raw materials according to the weight ratio, mix them and place them in a sealed container. Add 50%-70% ethanol, the volume of ethanol is 5-10 times the total weight of the herbs, ensuring that the herbs are completely covered. Soak at room temperature or in a cool place (below 20°C) for 15-30 days, stirring for 10-20 minutes daily. Filter to remove the dregs, collect the filtrate, and make the liniment. Efficacy focus and indications: Focuses on balancing cold and heat and comprehensive conditioning, suitable for diseases with mixed cold and heat (rheumatoid bone disease, sprains and bruises, burns, prostatitis, etc.). Instructions for use: Before use, wash the affected skin with warm water and dry it. Take the lotion in the palm of your hand or on a cotton swab, apply it evenly to the affected area, and gently massage for 3-5 minutes to promote drug absorption. Use it twice a day, morning and evening, for 7-14 days as one course of treatment.

[0016] Example 2: A topical Chinese medicine composition for treating a mixed cold and heat syndrome, consisting of the following Chinese medicine raw materials in the indicated weight ratios: 5 parts Aconitum carmichaelii, 5 parts Clematis chinensis, 4 parts Rheum palmatum, 3 parts Clematis armandii, 2 parts Boswellia carterii, 2 parts Commiphora myrrha, 3 parts Asarum heterotropoides, 3 parts Arisaema heterophyllum, 3 parts Zingiber officinale, 3 parts Taraxacum mongolicum, and 3 parts Luffa cylindrica. Preparation method of the liniment: Same as in Example 1; Efficacy focus and indications: It focuses on warming yang and dispelling cold, unblocking meridians and relieving pain, and is suitable for cold-dampness arthralgia (joint pain due to cold, aggravated by cold, rheumatoid arthritis, etc.). Instructions for use: Before use, apply a hot towel to the affected area for 5 minutes to open the pores. Take the lotion in your palm and apply it evenly to the affected area. Massage vigorously for 5-8 minutes until the area feels warm. After application, wrap the affected area with a towel and keep it warm for 30 minutes. Use 2-3 times a day for 10-15 days as one course of treatment.

[0017] Example 3: A topical Chinese medicine composition for treating a mixed cold and heat syndrome, consisting of the following Chinese medicine raw materials in the indicated weight ratios: 4 parts Aconitum carmichaelii, 4 parts Clematis chinensis, 5 parts Rheum palmatum, 2 parts Clematis armandii, 3 parts Boswellia carterii, 3 parts Commiphora myrrha, 2 parts Asarum heterotropoides, 2 parts Arisaema heterophyllum, 2 parts Zingiber officinale, 2 parts Taraxacum mongolicum, and 2 parts Luffa cylindrica. Preparation method of the liniment: Same as in Example 1; Efficacy focus and indications: It focuses on clearing heat and detoxifying, cooling blood and dispersing blood stasis, and is suitable for diseases with severe heat and toxicity (acute sprains, redness and swelling, burns, inflammatory pain, etc.). Instructions for use: During the acute phase, apply a cold compress to reduce redness and swelling. Apply the ointment to a cotton swab or gauze and gently apply it to the affected area. Avoid vigorous massage. Allow the ointment to dry naturally after application. No need to wrap it. Apply 3-4 times daily for 5-10 days as one course of treatment.

[0018] The following specific clinical cases demonstrate the beneficial effects of this invention. Clinical Case 1: 1. Patient Basic Information Name: Zhang, female, 52 years old; Chief complaint: Pain and swelling in the joints of both fingers for 1 year, which has worsened in the past 3 months; Medical History: One year ago, the patient developed pain in both finger joints without any obvious cause, with significant stiffness upon waking, which was slightly relieved after activity. The symptoms have worsened over the past three months, with increased pain upon exposure to cold or changes in weather, occasional localized burning sensation, accompanied by joint swelling and limited range of motion. The patient had previously taken Western painkillers with poor results and experienced stomach discomfort. Physical examination: Swelling of the joints of both fingers, slightly elevated skin temperature, obvious tenderness upon palpation, morning stiffness lasting about 45 minutes, pale red tongue, thin yellow and greasy coating, and wiry and thready pulse; 2. Treatment Plan Diagnosis: The root cause is Yang deficiency, the symptoms are cold-dampness-heat toxicity, and the condition is a mixed cold-heat type of arthralgia, specifically rheumatoid arthritis; Medication application: The herbal composition liniment from Example 1 was used. The liniment was applied to the joints of both hands and massaged for 5 minutes, once in the morning and once in the evening, for 14 consecutive days. 3. Treatment Results Recovery status: On the 3rd day, the pain was significantly reduced, and the morning stiffness time was shortened to 30 minutes; on the 7th day, the joint swelling subsided by about 50%, and the range of motion improved; on the 14th day, the pain basically disappeared, the morning stiffness time was shortened to 10 minutes, and the joint movement was basically normal. Follow-up results: One month after discontinuation of medication, there was no significant recurrence of symptoms, and the patient's satisfaction was high.

[0019] Clinical Case 2: 1. Patient Basic Information Name: Li, male, 28 years old; Chief complaint: Pain and swelling of the right ankle joint for 2 days after a sprain; Medical history: Two days ago, the patient sprained his right ankle while exercising. He experienced severe pain immediately, followed by significant swelling, redness and heat in the affected area, and limited mobility. Applying ice reduced the swelling slightly, but the pain remained significant. Physical examination: There was significant swelling on the lateral side of the right ankle joint, with elevated skin temperature, positive tenderness, and limited range of motion. The tongue was red with a thin yellow coating, and the pulse was wiry and rapid. 2. Treatment Plan Diagnosis: Blood stasis with heat toxicity, a mixed cold and heat type of traumatic injury, specifically an acute ankle sprain; Medication application: The herbal composition liniment from Example 1 was used. The liniment was applied to the affected area and gently massaged for 3 minutes, 3 times a day, for 7 consecutive days. 3. Treatment Results Recovery status: On the 2nd day, the swelling began to subside and the pain lessened; on the 4th day, the swelling subsided by about 70%, and the patient could walk slowly; on the 7th day, the swelling had basically subsided, the pain had disappeared, and the patient's activity level returned to normal. Follow-up results: Two weeks after discontinuation of medication, no sequelae were observed, and joint function fully recovered.

[0020] Clinical Case 3: 1. Patient Basic Information Name: Wang, male, 35 years old; Chief complaint: Pain and swelling on the back of the right hand for 3 days after a burn; Medical History: Three days ago, the patient accidentally scalded the back of his right hand with hot water while at work. He immediately experienced severe pain, redness, and swelling of the affected skin, followed by the appearance of small blisters. Applying toothpaste did not relieve the symptoms, and the pain persisted, affecting his sleep at night. He also experienced a burning sensation in the area, but the pain worsened upon exposure to cold wind. Physical signs: The skin on the back of the right hand is obviously red and swollen, with scattered small blisters. Some of the blisters have ruptured, and there is a small amount of exudate from the wound. The skin temperature is elevated, and the tenderness is positive. The tongue is red with a thin yellow coating, and the pulse is wiry and rapid. 2. Treatment Plan Diagnosis: The burn is a mixed type of heat and cold scald, specifically a second-degree burn (superficial second-degree burn). Medication application: The herbal composition liniment from Example 1 was used. First, the wound was cleaned with saline solution. The liniment was then applied to the affected area and surrounding skin with a cotton swab, avoiding vigorous massage. It was applied once in the morning and once in the evening for 10 consecutive days. 3. Treatment Results Recovery status: On the 2nd day, the pain was significantly reduced and the redness and swelling began to subside; on the 5th day, the blisters gradually dried up, the exudate from the wound decreased, and the pain was basically relieved; on the 10th day, the wound healed well, new epithelium formed, and there were no obvious scars. Follow-up results: One month after discontinuation of medication, the wound was completely healed, the skin color was close to normal, there was no functional impairment, and the patient's satisfaction was high.

[0021] Clinical Case 4: 1. Patient Basic Information Name: Zhao, male, 42 years old; Chief complaint: Perineal distending pain, frequent and urgent urination for 6 months, worsening in the past 2 weeks; Medical history: Six months ago, the patient developed perineal distending pain and discomfort without any obvious cause, accompanied by urinary frequency, urgency, and a burning sensation during urination. In the past two weeks, the symptoms worsened due to fatigue and alcohol consumption; the perineal distension became significant, and the pain intensified after prolonged sitting. The area felt cold, but there was a burning sensation during urination. Antibiotic treatment was previously administered, but the effect was poor. Physical examination: positive perineal tenderness, digital rectal examination revealed mild prostate enlargement with significant tenderness, dark red tongue with yellow and greasy coating, and wiry and slippery pulse; 2. Treatment Plan Diagnosis: Damp-heat accumulation with cold stagnation, a mixed cold-heat type of chronic prostatitis, specifically chronic nonbacterial prostatitis; Medication usage: The herbal composition liniment from Example 1 was used. The liniment was applied to the perineum and lower abdomen, and gently massaged for 5 minutes to promote drug absorption. It was used once in the morning and once in the evening, and a course of treatment lasted for 14 consecutive days. 3. Treatment Results Recovery status: On the 3rd day, the perineal distending pain was reduced and the urinary frequency symptoms improved; on the 7th day, the burning sensation during urination was significantly relieved and the pain was reduced after sitting for a long time; on the 14th day, the perineal distending pain basically disappeared, urination returned to normal, and the prostate tenderness was significantly reduced. Follow-up: One month after discontinuation of medication, there was no significant recurrence of symptoms, the patient's quality of life improved significantly, and the patient was satisfied with the treatment effect.

[0022] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of this embodiment in any way. Any person skilled in the art can make many possible variations and modifications to the present invention using the methods and techniques disclosed above, or modify it into equivalent embodiments with equivalent changes, without departing from the scope of the present invention; all such modifications shall still fall within the protection scope of the present invention.

Claims

1. A topical traditional Chinese medicine composition for treating diseases with mixed cold and heat patterns, characterized in that, It is composed of the following Chinese herbal raw materials in the following weight ratios: Aconitum carmichaelii 4-5 parts, Clematis chinensis 4-5 parts, Rheum palmatum 4-5 parts, Clematis chinensis 2-3 parts, Boswellia carterii 2-3 parts, Commiphora myrrha 2-3 parts, Asarum heterotropoides 2-3 parts, Arisaema heterophyllum 2-3 parts, Zingiber officinale 2-3 parts, Taraxacum mongolicum 2-3 parts, and Luffa cylindrica 2-3 parts.

2. The topical traditional Chinese medicine composition for treating mixed cold and heat syndromes according to claim 1, characterized in that: The traditional Chinese medicine composition consists of the following raw materials in the indicated weight ratios: Aconitum carmichaelii 4.5 parts, Clematis chinensis 4.5 parts, Rheum palmatum 4.5 parts, Clematis armandii 2.5 parts, Boswellia carterii 2.5 parts, Commiphora myrrha 2.5 parts, Asarum heterotropoides 2.5 parts, Arisaema heterophyllum 2.5 parts, Zingiber officinale 2.5 parts, Taraxacum mongolicum 2.5 parts, and Luffa cylindrica 2.5 parts.

3. The topical traditional Chinese medicine composition for treating mixed cold and heat syndromes according to claim 1, characterized in that: The traditional Chinese medicine composition consists of the following raw materials in the indicated weight ratios: 5 parts Aconitum carmichaelii, 5 parts Clematis chinensis, 4 parts Rheum palmatum, 3 parts Clematis armandii, 2 parts Boswellia carterii, 2 parts Commiphora myrrha, 3 parts Asarum heterotropoides, 3 parts Arisaema heterophyllum, 3 parts Zingiber officinale, 3 parts Taraxacum mongolicum, and 3 parts Luffa cylindrica.

4. The topical traditional Chinese medicine composition for treating mixed cold and heat syndromes according to claim 1, characterized in that: The traditional Chinese medicine composition consists of the following raw materials in the indicated weight ratios: 4 parts Aconitum carmichaelii, 4 parts Clematis chinensis, 5 parts Rheum palmatum, 2 parts Clematis armandii, 3 parts Boswellia carterii, 3 parts Commiphora myrrha, 2 parts Asarum heterotropoides, 2 parts Arisaema heterophyllum, 2 parts Zingiber officinale, 2 parts Taraxacum mongolicum, and 2 parts Luffa cylindrica.

5. The external Chinese medicine composition for treating mixed cold and heat syndromes according to claim 1, characterized in that, The dosage form of the traditional Chinese medicine composition is a topical liquid preparation, topical ointment, topical gel, topical spray, or topical patch.

6. The external Chinese medicine composition for treating mixed cold and heat syndromes according to claim 1, characterized in that, The dosage form of the traditional Chinese medicine composition is a liniment. The preparation method is as follows: weigh the traditional Chinese medicine raw materials according to the weight ratio, mix them and place them in a sealed container, add 50%-70% ethanol, the amount of ethanol is 5-10 times the total weight of the medicinal materials, soak in room temperature or in a cool place for 15-30 days, filter to remove the dregs, collect the filtrate, and make the liniment.