79 results about "Thyroid tumors" patented technology

The present disclosure provides methods for the treatment of cell proliferative disorders by administration of a RET kinase inhibitor. Cell proliferative disorders treatable by the methods include, thyroid tumors.

The invention discloses a thyroid tumor pathological tissue section image classification method and a thyroid tumor pathological tissue section image classification device. The method comprises the steps of acquiring an original image set of classified thyroid tumor pathological tissue sections; automatically intercepting multiple area images including cells from each original image to serve as asub-image set; using the total or partial sub-image set as a training set; building a preliminary convolutional neural network model; training the preliminary convolutional neural network model by using the training set to acquire a mature convolutional neural network model; and classifying the classified thyroid tumor pathological tissue section images by using the mature convolutional neural network model. Cell nucleuses in the thyroid tumor pathological tissue sections are matched by using Gaussian laplace operator characteristics to find positions of cells, automatic image interception isimplemented in the area with many cells, so that the full-automatic cell image classification and cancer diagnosis are achieved, the workload of a doctor when in checking of the tissue section image can be greatly reduced, and the diagnosis accuracy is improved.

The invention discloses an automatic identification method of a thyroid tumor ultrasound image based on faster r-cnn. The method comprises the following steps: performing data enhancement on a markedthyroid tumor ultrasound image, and increasing the number and scale of training samples; performing feature extraction on an image data set by using a resnet-50 network model; generating a proposal window (proposals) by using a region proposal network RPN, and mapping the proposal window onto a feature map to generate a region proposal box; then causing each RoI to generate a feature map with a fixed size through RoI pooling; and finally performing joint training on a classification probability and border regression by using softmax Loss and softmax L1 Loss. By adoption of the method disclosedby the invention, the tumor ultrasound image does not need to be manually segmented, end-to-end network training can be achieved, and the identification rate is improved by data enhancement.

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

The invention discloses a thyroid tumor ultrasonic image recognition method and device, and the method comprises the steps: selecting a tumor region in a thyroid tumor ultrasonic image, extending a certain boundary scope and then performing cutting, carrying out the benign and malignant marking, and enabling the cut images to form a training set; training a selected CNN (Convolutional Neural Network) through the training set, and forming a thyroid tumor ultrasonic image recognition model; obtaining a to-be-recognized thyroid tumor ultrasonic image, selecting a tumor region and extending a certain boundary scope, and carrying out the benign and malignant recognition through the thyroid tumor ultrasonic image recognition model. The method and device are used for assisting a doctor to diagnose the benign and malignant thyroid tumors, obtain the accuracy of 90% or greater in the detection test of the benign and malignant thyroid tumors through the thyroid tumor ultrasonic image, and is ofgreat reference significance to the actual clinical diagnosis.

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

The invention discloses a network construction method and system for thyroid tumor cytology smear image classification. According to the system, an intensive learning method is used to find an existing convolutional neural network which is most suitable for thyroid tumor cytology smear image classification. The specific process of the intensive learning method comprises a step of generating a convolutional neural network by using a circulating neural network, a step of training the convolutional neural network by using a thyroid tumor cytology smear image training set, a step of verifying theaccuracy of the trained convolutional neural network by using a thyroid tumor cytology smear image verification set, setting an accuracy threshold, and determining whether the accuracy is higher thanthe threshold, and a step of taking a convolutional neural network with highest accuracy as a preliminary convolutional neural network and training the network again. The purposes of constructing theconvolutional neural network with high accuracy to assist a doctor in the diagnosis of thyroid tumors and improving the accuracy of diagnosis are achieved.

The invention concerns a head for imaging and treating a living being's organ or tissue, in particular useful for treating prostate or thyroidal tumors, said head comprising imaging means (2), such as an ultrasound probe, for emitting waves or rays to provide an image representation of a tissue or organ to be treated, treating means (4) for locally treating said tissue or organ, the treating means being capable of emitting waves or rays for treating the tissue or organ. The invention is characterized in that the imaging means (2) are removably mounted on an adapter (3; 3') for positioning the imaging means (2) relative to the treating means (4).

A traditional Chinese medicine for curing thyroid adenoma belongs to a traditional Chinese medicine for curing swollen masses goiter. The components contain: 15g of rhizoma dioscoeae bulbiferae, 15g of rehmannia root, 15g of turmeric root tuber, 12g of figwort root, 12g of thunberg fritillary bulb, 12g of pinellia tuber, 12g of green tangerine peel, 25g of raw oyster and 20g of calcined corrugate; the invention has the auxiliary prescriptions that: for choking sensation in chest, 20g of snakegourd fruit and 20g of nutgrass galingale rhizome are added; for hard mass, 12g of nidus vespae and 12g of zedoray rhizome are added; for irregular menstruation, 15g of Chinese Angelica, 15g of motherwort herb and 15g of szechwan lovage rhizome are added. The substances in the prescription are made from natural traditional Chinese medicine plus traditional preparing methods. The materials are easy to collect, the prescription and the preparation methods are simple, and the cost of medicine preparation is low. The compatibility of the traditional Chinese medicine is simple; the medicine used in the prescription is fully natural herbal medicine, which is easy to collect and use; the preparation method is simple; the effects for taking and curing are good; the cost of the medicine is low, and the medicine is in particular suitable for the people living in remote villages far from towns; the cost is low for curing the people suffering from thyroid adenoma, which solves the problem that the local area lacks medical conditions to cure the disease because of low household income and poor living condition.

The invention discloses a classification method and device of a thyroid tumor cytology smear image. The method comprises a step of obtaining a certain size of a benign and malignant labeled thyroid tumor cytology smear image, a step of using the acquired image to form a training set and carrying out data amplification on the training set, a step of generating a preliminary convolutional neural network, a step of training the preliminary convolutional neural network by using the amplified training set, optimizing parameters such that benign and malignant cells in the thyroid tumor cytology smear image can be judged and a mature convolutional neural network is formed, a step of obtaining a thyroid tumor cytology smear image to be identified and carrying out benign and malignant judgment on the cells in the image by using the mature convolutional neural network, and a step of outputting a benign result if all cells in the image are judged to be benign and outputting a malignant result ifat least one cell in the image is malignant. The method and the device are used to assist a doctor in diagnosing a thyroid tumor, and the accuracy of the diagnosis is improved.

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

The invention relates to a gene relevant to papillary thyroid tumors and an application thereof. According to the base sequence of the gene, real-time and quantitative PCR (Polymerase Chain Reaction) primers are designed and synthesized; the expression level of long-chain non-coding RNA (Ribonucleic Acid) transcribed by the gene is detected in a papillary thyroid carcinoma clinical case specimen; the result shows remarkable reducing of the expression level of the long-chain non-coding RNA in papillary thyroid tumor tissues and the long-chain non-coding RNA of the gene silencing can remarkably promote the growth of thyroid cancer cells. The gene relevant to the papillary thyroid tumors is expected to prepare preparations used in papillary thyroid carcinoma auxiliary diagnosis, gene therapy, curative effect prediction or prognosis.

The present invention relates to a kind of Chinese medicine preparation, named Jiazhuangling, for treating hyperthyroidism, thyroid tumor, thyroid cyst and endemic goiter. The Chinese medicine preparation has obvious curative effect, short treating period and less recurrence.

The invention discloses a cold tip temperature control fissure microwave ablation radiator, which comprises a stainless steel puncture needle, a polytetrafluoroethylene ring, a stainless steel shielding tube, a sealing ring, a closed piece, a hard coaxial cable, a cable connector and a microwave input seat. The front end of the stainless steel puncture needle is in a conical shape and the round bottom face of the rear end has a cylindrical boss; the stainless steel puncture needle is connected with the stainless steel shielding tube through the polytetrafluoroethylene ring; the hard coaxial cable is positioned in the stainless steel shielding tube and is connected with the microwave input seat through a cable connector; an annular inner cavity is formed between the stainless steel shielding tube and the hard coaxial cable; and the sealing ring is positioned in the annular inner cavity of the end port, which is close to the polytetrafluoroethylene ring, of the stainless steel shielding tube; and the closed piece is positioned in the annular inner cavity of the other port of the stainless steel shielding tube. The cold tip temperature control fissure microwave ablation radiator can directly puncture thyroid tumor which is less than 2 centimeters and form a spherical condensing area, thereby radically ablating the thyroid tumor.

The invention provides a tumor eliminating powder, including: Uroctea 1-10 shares, batryticated silkworm 2-8 shares, pod 2-15 shares, vermilion 1-6 shares, Fructus Ziziphi Jujubae 5-20 shares, spider 3-12 shares, and also including: Chinese angelica 3-12 shares, Mamyflower Gueldemstaedtid Herb 3-15 shares, and Commiphora Myrrha 1-10 shares. It can be applied to cure proliferation of mammary gland, mastitis, mastadenoma, poisoned sore, thyroid tumor, lymphoma, etc, and its curative effect is good and it has no toxicity and side effect.

The invention discloses a thyroid pathology image classification method and terminal equipment based on multiple modalities, and the method comprises the steps: carrying out the information feature extraction of thyroid pathology images of three modalities through employing three ResNet18 networks, obtaining three-modal information features, and carrying out the classification of thyroid pathology images of three modalities; the thyroid pathology images in the three modes comprise a thyroid ultrasound image, a thyroid elasticity image and a thyroid blood flow image; adopting a multi-mode multi-head attention module to extract common information features of the thyroid pathology images of the three modes; and fusing the three-mode information features and the common information features, performing thyroid pathology image classification by using a residual network, and outputting a classification result. The designed multi-modal thyroid pathology image classification method is verified on a multi-modal thyroid ultrasound data set provided by a cooperative research unit, and a result proves that the thyroid pathology images can be accurately classified by the method, so that rapid and accurate assistance is provided for diagnosis of thyroid cancer by an ultrasound department doctor.

The invention discloses a kit for predicting thyroid tumors to be benign or malignant. The kit contains primers for detecting the expression quantities of DPP4 genes, SCG5 genes and CA12 genes respectively. The sequences of the primers are shown as SEQ ID NO.1 to SEQ ID NO.6 respectively. According to the kit, the expression of the three kinds of genes (DPP4, SCG5 and CA12) is detected, and the benign thyroid tumors and the malignant thyroid tumors are classified with a Bayesian model averaging method (BMA); a gene combination has the high accuracy (94.3%); compared with a gene chip, the kit has the advantages of being low in cost, easy and convenient to operate, easy to standardize, high in clinic applicability and the like.

The invention discloses a traditional Chinese medicine composition for treating thyroid tumor. The traditional Chinese medicine composition comprises a medicine for external application and a medicine for oral administration, wherein the medicine for oral administration is prepared from the following raw medicinal materials in parts by weight: 10-18 parts of radix bupleuri, 7-15 parts of roasted rhizoma atractylodis macrocephalae, 11-19 parts of dried orange peel, 8-15 parts of ligusticum wallichii, 4-13 parts of Processed Rhizoma Pinelliae, 5-14 parts of fructus forsythia, 5-15 parts of rhizoma bolbostemmae, 2-9 parts of liquorice, 5-11 parts of pericarpium citri reticulatae viride, 7-20 parts of concha meretricis seu cyclinae, 5-13 parts of angelica sinensis, 13-19 parts of caulis trachelospermi, 4-10 parts of air potato and 5-12 parts of solidago; the medicine for external application comprises cuttlebone and honeysuckle stem. The traditional Chinese medicine composition which is used for treating benign thyroid tumor is developed according to a folk prescription and the traditional Chinese medicine theory of reinforcing the vital energy and consolidating the constitution, and promoting blood circulation to remove blood stasis, and has the effects of regulating the flow of qi and resolving depression, and softening hardness and transforming phlegm; the traditional Chinese medicine composition is used for treating the benign thyroid tumor by use of combined internal and external therapy, and is good in effect without toxic and side effects, and low in price.

This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the β sequence and the amount of TERT mRNA in the sample which comprises the β sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the β sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the β sequence indicates that the tumor is not malignant.

The invention relates to the technical field of medical diagnostics. Thyroid tumors can be divided into two types including benign tumors and cancers. The property of a thyroid nodule is difficult to determine clinically; and even if biopsy is carried out, the benign tumors and the cancers are not easy to clearly identify due to thyroid adenomas and focal nodular hyperplasia. The invention provides a blood micro-molecular metabolin specific chromatogram which is used for identifying papillary thyroid carcinomas, benign thyroid tumors and blood of normal people, and a manufacturing method of the blood micro-molecular metabolin specific chromatogram. A micro-molecular metabolin comprises two blood metabolin marks, namely palmityl carnitine and carnitine; the molecular weights of the palmityl carnitine and the carnitine are 400.2634 and 161.20; and corresponding ions detected on a mass spectrum are 404.5532 and 160.7866. A clinical experiment shows that the accuracy of applying a chromatogram formed by a specific value of the two metabolism micro-molecules to judge the thyroid cancer is 74% and the accuracy of judging non-cancer (the benign thyroid tumor and the normal people) is 72.3%. The blood micro-molecular metabolin specific chromatogram disclosed by the invention has the advantage of high sensitivity and can be prepared into a diagnosis kit for screening and auxiliary diagnosis of the thyroid cancer.

The invention relates to a methylation marker for identification of benign and malignant thyroid tumors and evaluation of follicular tumors with uncertain malignant potential, and a method for constructing an identification model for benign and malignant thyroid tumors. The method comprises the following steps of: (1) acquiring the methylation levels of candidate sites or fragments in genome DNAsof a tumor sample and a control sample; (2) processing the methylation levels of the sites or fragments by using at least one algorithm selected from a group consisting of mhl, mhl3, umhl and pdr; (3)screening out a site or fragment having significant difference between the processed methylation level of the tumor sample and the processed methylation level of the control sample, and screening outan optional corresponding algorithm, wherein the site or fragment is the methylation marker; and (4) constructing the model for identifying benign and malignant thyroid cancer according to the processed methylation levels of the methylation marker.

The invention discloses a microwave ablation needle for treating thyroid tumors and belongs to microwave ablation needles. The microwave ablation needle comprises a needle body. A handle is mounted at the tail end of the needle body. A puncture head is disposed at the front end of the needle body. A radiator is mounted at the rear end of the puncture head. A radiation window wraps the radiator. A focusing reflecting ring is disposed at the rear end of the radiation window and in contact with the end of the needle body. A coaxial cable is further disposed inside the needle body. The radiator is connected into a radio frequency coaxial connector through the coaxial cable. Due to the fact that the radiation window wraps the radiator and is connected with the focusing reflecting ring, a focusing reflecting structure is formed at the tip of the ablation needle, the microwaves emitted by the radiator gather at the front end of the tip of the ablation needle and do not reflect backwards, effectiveness of the microwaves is increased effectively, and tumor ablation standing wave ratio can be realized with a relative-short needle tip during actual application. In addition, the needle body is lightweight, tumor ablation flexibility is increased, and the ablation needle is suitable for being operated by a single person.

The invention provides a traditional Chinese medicine preparation for treating metaphase thyroid tumor, wherein the traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials by weight: 10 parts of rhizoma dioscoreae bulbiferae, 15 parts of prunella vulgaris, 50 parts of milkvetch root, 25 parts of codonopsis pilosula, 15 parts of atractylodes macrocephala, 25 parts of angelica sinensis, 15 parts of radix paeoniae rubra, 15 parts of seaweed, 15 parts of kelp, 50 parts of oyster, 25 parts of ligusticum chuanxiong hort, 10 parts of pangolin, 50 parts of radix rehmanniae preparata, 12 parts of rhizoma sparganii, 12 parts of curcuma zedoaria, 10 parts of cyperus rotundus, 10 parts of semen persicae, 15 parts of fructus toosendan, 6 parts of safflower, 10 parts of Chinese honeylocust spine, and 10 parts of tripterygium wilfordii. According to the present invention, the is the nature raw material traditional Chinese medicine, does not contain any chemical additives, has effects of liver soothing, qi regulating, lump softening and knot loosening, blood circulation activation, blood stasis removing and the like, has advantages of complete thyroid tumor treatment, good treatment effect, no toxic-side effect, quick recovery, less recurrence, short treatment cycle, low cost, rich sources of selected traditional Chinese medicine bulk drugs, and easy promotion application.

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

The invention discloses a surgical navigation device for ultrasonically guiding thermal ablation of thyroid tumors. The surgical navigation device for ultrasonically guiding thermal ablation of thyroid tumors comprises an optical positioning device (1), a tracked object (2), two-dimensional handheld ultrasonic scanning equipment (3), an ultrasonic probe (4), an image workstation (5) and display equipment (6). Wherein the ultrasonic probe (4) is connected with the two-dimensional handheld ultrasonic scanning equipment (3), the image workstation (5) further comprises an image acquisition card (51), the two-dimensional handheld ultrasonic scanning equipment (3) outputs signals to the image acquisition card (51), and the signals are processed by the image acquisition card (51) and then output to the display equipment (6).

The invention discloses a thyroid tumor radiofrequency ablation device based on recurrent laryngeal nerve detection. The thyroid tumor radiofrequency ablation device comprises a recurrent laryngeal nerve detecting instrument, a thyroid tumor radiofrequency ablation instrument and a detection and ablation integrated needle, wherein the recurrent laryngeal nerve detecting instrument and the thyroidtumor radiofrequency ablation instrument are both connected to the detection and ablation integrated needle, the detection and ablation integrated needle is used for recurrent laryngeal nerve detection when being independently connected with the recurrent laryngeal nerve detecting instrument and is used for ablating pathological tissues of the thyroid tumor when being independently connected withthe thyroid tumor radiofrequency ablation instrument. The thyroid tumor radiofrequency ablation device integrates recurrent laryngeal nerve detection and ablation of the pathological tissues of the thyroid tumor, enables the detection and ablation integrated needle to have a recurrent laryngeal nerve detecting function, firstly performs early warning of recurrent laryngeal nerve detection before ablation of a dangerous zone, avoids the possibility of thermal ablation injury of recurrent laryngeal nerve, accordingly improves the safety of thyroid tumor radiofrequency ablation, meanwhile can achieve two purposes through one needle, decreased puncture times and decreases traumas of patients.

The invention discloses a medicine for treating thyroid tumor and a preparation method thereof. The medicine is mainly prepared from oyster, coptis chinensis, edible tulip, radix ranunculi ternati, kelp, fructus arctii, angelica sinensis, fructus trichosanthis, honeysuckle stem, seaweed, radix scrophulariae, sargentgloryvine stem, artemisia anomala, radix gentianae, prunella vulgaris, spina gleditsiae, dandelion, rhizoma sparganii, dried orange peel, bulbus fritillariae cirrhosae and curcuma zedoary according to certain weight ratios. The medicine disclosed by the invention has the functions of drying dampness and resolving phlegm, replenishing and activating blood, moving qi and alleviating depression and purging excess liver fire, and realizes fast and good effects without relapse when used for treating thyroid tumor.

The invention relates to medicine for treating thyroid tumor. The medicine comprises, by weight, 15 parts of radix isatidis, 15 parts of oldenlandia diffusa, 10 parts of red flower, 20 parts of honeysuckle, 15 parts of tangerine peel, 20 parts of rabdosia yuennanensis (graminaceous), 10 parts of snake slough, 10 parts of seaweed, 10 parts of kelp, 10 parts of mung bean, 15 parts of dried radix rehmanniae, 20 parts of spina gleditsiae, 15 parts of fructus forsythia, 20 parts of wax gourd peel and 20 parts of radix achyranthis bidentatae. The medicine has the advantages that thyroid tumor analysis by the traditional Chinese medicine dialectic theory shows that the thyroid tumor belongs to liver damage caused by depression and anger, liver smoothness loss, qi depression transforming into fire, meridian blocking, phlegm carrying and stagnation and phlegm accumulation at the neck, the thyroid tumor can be treated by taking the traditional Chinese medicine with effects of regulating qi-flowing for eliminating phlegm, dissipating depression and softening hard mass, promoting blood circulation to remove blood stasis and clearing away heat and phlegm, and the medicine is evident and stable in curative effect.

A thyroid puncture outfit disclosed in the invention comprises a puncture needle, a cavity penetrating through the two ends of the puncture needle is formed in the puncture needle, a puncture sharp part is arranged at one end of the puncture needle, and a negative pressure extraction part is arranged at the other end of the puncture needle. A scraping and rotating device used for scraping the inner wall tissue of the thyroid tumor in the rotating process is rotationally installed in the cavity. The cavity is formed in the puncture needle, then the scraping and rotating device is arranged in the cavity, the inner wall tissue of a thyroid tumor can be effectively scraped through low-speed rotation of the scraping and rotating device, and thyroid epithelial cells falling off from the thyroid tumor can be sucked out, so the detection rate is greatly increased; and the thyroid puncture outfit is of a mechanical structure, so implementation is easy, and fine needle aspiration biopsy under the guidance of color ultrasound can be easily popularized to primary hospitals.