MIRNA expression signature in classification of thyroid tumors

A technology of thyroid and expression profiling, which is applied in the direction of antineoplastic drugs, microbial determination/testing, biochemical equipment and methods, etc.
CN106460053AInactive Publication Date: 2017-02-22ROSETTA GENOMICS
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
ROSETTA GENOMICS
Publication Date
2017-02-22
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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Description

technical field

[0001] The present invention relates to methods for the classification of thyroid tumors. In particular, the present invention relates to microRNA molecules associated with specific thyroid tumors.

[0002] Background of the invention

[0003] Accurate diagnosis of thyroid nodules continues to challenge physicians treating patients with thyroid disease. Diagnostic surgery is usually performed in patients with cytologically indeterminate nodules, although the majority of these nodules turn out to be benign after surgery. This limitation of FNA cytology in preoperative diagnosis leads to the clinical need for reliable preoperative molecular markers to distinguish benign from malignant thyroid nodules. MicroRNAs (miRs) are an important class of regulatory RNAs that have profound effects on a wide range of biological processes. These small (typically 18 to 24 nucleotides in length) noncoding RNA molecules can regulate protein expression patterns by promoting RN...

Claims

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