Mirna expression signature in the classification of thyroid tumors

a thyroid tumor and expression signature technology, applied in the field of thyroid tumor classification methods, can solve the problems of rapid or irregular heartbeat, nervousness, weight loss, and feeling of being too warm
US20170356055A1Inactive Publication Date: 2017-12-14ROSETTA GENOMICS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ROSETTA GENOMICS
Publication Date
2017-12-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to methods for classification of thyroid tumors. Specifically the invention relates to microRNA molecules associated with specific thyroid tumors.BACKGROUND OF THE INVENTION

[0002] The accurate diagnosis of thyroid nodules continues to challenge physicians managing patients with thyroid disease. Patients with cytologically indeterminate nodules are often referred for diagnostic surgery, though most of these nodules prove post-surgery to be benign. This limitation of FNA cytology in the pre-operative diagnosis leads to a clinical need for reliable pre-operative molecular markers to distinguish benign from malignant thyroid nodules. MicroRNAs (miRs) are an important class of regulatory RNAs, which have a profound impact on a wide array of biological processes. These small (typically 18-24 nucleotides long) non-coding RNA molecules can modulate protein expression pattern by promoting RNA degradation, inhibiting mRNA translation, a...

Claims

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