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Classification method and device of thyroid tumor cytology smear image

A thyroid tumor and classification method technology, applied in the field of thyroid tumor fine needle aspiration cytology smear image classification method and device field, can solve problems such as lack of, inability to analyze benign and malignant thyroid cytology smear, lack of diagnostic experience, etc.

Active Publication Date: 2018-09-21
FUDAN UNIV SHANGHAI CANCER CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of relevant cytopathology professionals and lack of diagnostic experience, many hospitals cannot make accurate benign and malignant analysis of thyroid cytology smears

Method used

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  • Classification method and device of thyroid tumor cytology smear image
  • Classification method and device of thyroid tumor cytology smear image
  • Classification method and device of thyroid tumor cytology smear image

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1 classifies with the neural network constructed by VGG-16

[0090] Obtain a certain size of thyroid tumor cytology smear images marked with benign and malignant

[0091] 1. Obtain photomicrographs of thyroid cytology smears

[0092] The data set in this example was collected from patients with thyroid nodules by the Cancer Hospital Affiliated to Fudan University. The hospital conducts a puncture examination of thyroid tumors on patients suspected of having malignant thyroid nodules, obtains thyroid tumor cell samples, conducts smear tests on them, obtains micrographs, and marks them as benign and malignant.

[0093] The micrographs of these cell smears were all at the same magnification of 400×; the dataset contained 159 malignant micrographs and 120 benign micrographs, each from a different patient.

[0094] 2. Extracting discriminative regions from photomicrographs

[0095] Multiple 224×224 pictures were cut from each photomicrograph of thyroid cytology...

Embodiment 2

[0116] Embodiment 2 classifies with the neural network constructed by Inception V3

[0117] The construction and classification method of this embodiment is the same as that of Embodiment 1, the only difference is that when using Inception V3, the image is enlarged to 299×299 before input.

Embodiment 3V

[0118] Comparison of the neural network constructed by embodiment 3VGG-16 and Inception V3

[0119] Test the accuracy of the two network models with the test set in the above embodiment. The test accuracy can accurately reflect the effect of the two convolutional neural networks on the classification task of thyroid tumor fine-needle aspiration cytology smear images. In addition, this embodiment also counts the sensitivity, specificity, positive predictive value, and negative predictive value of the two methods, and the results are shown in Table 1.

[0120] Table 1 The effect of VGG-16 and Inception V3 on the test set

[0121]

[0122] As can be seen from Table 1, the accuracy of VGG-16 on the test set is very high, reaching 97.66%. The effect of Inceptionv3 is relatively poor, but it also reached 92.75%. This shows that the two kinds of neural networks in the present invention have achieved good results in image analysis of thyroid tumor cytology smears.

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Abstract

The invention discloses a classification method and device of a thyroid tumor cytology smear image. The method comprises a step of obtaining a certain size of a benign and malignant labeled thyroid tumor cytology smear image, a step of using the acquired image to form a training set and carrying out data amplification on the training set, a step of generating a preliminary convolutional neural network, a step of training the preliminary convolutional neural network by using the amplified training set, optimizing parameters such that benign and malignant cells in the thyroid tumor cytology smear image can be judged and a mature convolutional neural network is formed, a step of obtaining a thyroid tumor cytology smear image to be identified and carrying out benign and malignant judgment on the cells in the image by using the mature convolutional neural network, and a step of outputting a benign result if all cells in the image are judged to be benign and outputting a malignant result ifat least one cell in the image is malignant. The method and the device are used to assist a doctor in diagnosing a thyroid tumor, and the accuracy of the diagnosis is improved.

Description

technical field [0001] The present invention relates to the field of image recognition, in particular to a deep learning-based method for classifying thyroid tumor fine-needle aspiration cytological smear images and a device thereof. Background technique [0002] Thyroid cancer is the most common malignant tumor of the endocrine system. Thyroid nodules refer to tumors in the thyroid gland. In view of the high incidence of thyroid nodules, thyroid malignancies only account for a very small part of them. If as many thyroid malignancies as possible can be identified through non-surgical methods, then Significantly reducing the number of unnecessary diagnostic operations can not only reduce the damage to patients caused by the operation, but also make more reasonable use of limited medical resources. Thyroid tumor fine-needle aspiration cytology smear is currently the most accurate and cost-effective preoperative examination method for evaluating thyroid nodules. However, due ...

Claims

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Application Information

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IPC IPC(8): G06K9/62G06N3/04G06N3/08
CPCG06N3/08G06N3/045G06F18/2413
Inventor 向俊卢宏涛官青王蕴珺平波万晓春李端树杜佳俊秦宇
Owner FUDAN UNIV SHANGHAI CANCER CENT
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