31 results about "Traumatic brain damage" patented technology

Described herein is the use of ultrasound pulses at different frequencies to track the dispersion properties of intracranial tissues which may have been altered due to traumatic or other neurological brain injury. Dispersive ultrasound does not provide imaging, but it can provide data of significant diagnostic value by using decision support systems that can be trained as a medical diagnostic system for traumatic brain injuries applications to detect specific patterns of dispersion that are associated with specific intracranial injuries.

The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and / or eliminating long-term adverse effects in these patients.

The invention belongs to an oral Chinese herbal preparation for treating post-traumatic brain syndrome, and the oral Chinese herbal preparation is a human medicinal product. The preparation is prepared from the following Chinese herbs in parts by weight: 10+ / -2 parts of Astragalus mongholicus, 10+ / -2 parts of American ginseng, 10+ / -2 parts of Angelica sinensis, 10+ / -2 parts of medlar, 10+ / -2 parts of the root of red-rooted salvia, 10+ / -2 parts of ligusticum wallichii, 10+ / -2 parts of root of common peony, 10+ / -2 parts of peach kernel, 10+ / -2 parts of Poria cocos, 10+ / -2 parts of pericarpium citri reticulatae, 10+ / -2 parts of plantain seed, 10+ / -2 parts of tabasheer, 10+ / -2 parts of rhizoma acori graminei, 10+ / -2 parts of gastrodia elata, 10+ / -2 parts of uncaria, 10+ / -2 parts of spina date seed, 10+ / -2 parts of amber powder and 6+ / -1.2 parts of honey-fried licorice root. Clinical effect observation proves that the total effective rate of the oral Chinese herbal preparation to the oral traditional Chinese medicine preparation is 94.07%, and has better treatment effect (P<0.01) compared with Western medicines such as Rotundine, piracetam, oryzanol and nimodipine for treating post-traumatic brain syndrome. Moreover, the Chinese herbal preparation has no obvious toxic or side effect, and can be taken for a long time. The dose of the preparation is small, and effective medicinal components are easy to release, can be absorbed quickly and can fully play the pharmaceutical effect. The preparation is convenient to carry, easy to take and beneficial to large-scale production.

The invention provides methods for treating traumatic brain injury. The invention is generally directed to treating traumatic brain injury by administering cells that have one or more of the following effects in an injured subject: interact with splenocytes, preserve splenic mass, increase proliferation of CD4+ and CD8+ T-cells, increase IL-4 and IL-10, and increase M2:M1 macrophage ratio at the site of injury. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to have these effects. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for achieving these effects.

The present disclosure relates to glycan-based biomarkers for the diagnosis or prognosis of brain damage, such as traumatic brain injury (TBI).

A method of preventing, alleviating or treating traumatic brain injury in an individual comprises administering to the individual a therapeutically effective and physiologically acceptable amount of an agent capable of reducing the amount of one or more aggregated forms of one or more peptides in the brain. An agent capable of reducing the amount of one or more aggregated forms of one or more peptides in the brain is suitable for use in preventing, alleviating or treating traumatic brain injury. A method for predication of the risk of an individual for complications after a traumatic brain injury comprises detecting one or more aggregated forms of one or more peptides prone to aggregate as a result of a traumatic brain injury event, in the brain of the individual, wherein an increased level of such aggregates in the brain indicates an increased risk for complications.

The invention relates to the field of medicine application, in particular to application of a glibenclamide composition in preparation of a medicine for treating or preventing brain water content increase caused by traumatic brain injury, and the glibenclamide composition is a glibenclamide cyclodextrin composition for injection. Preferably, the glibenclamide and cyclodextrin composition for injection is prepared from glibenclamide, cyclodextrin and an additive, experimental results show that each dose of the glibenclamide cyclodextrin composition for injection can significantly reduce the brain water content of rats with traumatic brain injury.

The present invention discloses a brain-targeted exosome which comprises an exosome capable of passing through blood brain barrier and a fluorescent material with an imaging function, wherein the fluorescent material is distributed in the entocoele of the exosome. The invention also discloses a preparation method of the brain-targeted exosome, and the method comprises: enabling brain-targeted neural stem cells to secret an exosome with a brain-targeted peptide; collecting and purifying the exosome; and enabling the fluorescent material to enter the entocoele of the exosome so as to obtain thebrain-targeted exosome. The brain-targeted exosome provided by the present invention is mainly formed by natural materials, has a function of passing through blood brain barrier, can overcome the problem that traditional nano-particles have low efficiency of passing through blood brain barrier and have toxic or side effect, overcomes the difficulty of brain targeting of traditional particles, andprovides a visible and accurate treatment strategy for treating brain-related diseases such as traumatic brain injury and brain tumors.

The invention belongs to the field of medicine and discloses the application of a class of ursolic acid derivatives in the preparation of medicines for treating nervous system diseases. The present invention utilizes microbial transformation technology to successfully modify the structure of ursolic acid, and obtains 4 novel compounds with structural modification of the mother nucleus, which are confirmed by in vitro nerve cell injury protection tests and neuroglial cell inflammation tests. The compound has better nerve cell protection activity and anti-neurinflammation activity, can be used as an active ingredient of drugs for treating neurodegenerative diseases, traumatic brain injury, and stroke, and has wide applications.

Blast Induced Traumatic Brain Injury or bTBI needs objective and subjective testing that can be made quickly in the field. Subjective tests using shapes, textures, tastes and odors as disposable, edible candies on a stick may be carried in a field kit. An objective test that employs a similar candy on a stick bearing antibodies bound to bioluminescent marker reads whether molecules believed to be released into the mouth from an injured brain are present if they bind to the specific antibody which may then be read.

Methods and compounds for treating, inhibiting, and preventing traumatic brain injury are provided. Methods include administering 7,8-dihydroxyflavone and derivatives thereof.