Compositions and methods for treating and preventing neuronal damage from traumatic brain injury
Patent Information
- Authority / Receiving Office
- CN ยท China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ้้ฆ่พ
- Publication Date
- 2018-04-27
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Abstract
Description
[0001] government interest
[0002] This invention was supported by the US National Institutes of Health, Grant No. NS072631. The government has certain rights in this invention. Background technique
[0003] Traumatic brain injury (TBI) is a leading cause of death and disability in children and young adults (Aitken et al., 2009; McCarthy et al., 2006). TBI induces neuronal death in the brain, including hippocampal and cortical regions. TBI can not only cause primary injury through direct tissue loss (Hall et al., 2004; Hall et al., 2005b; Singh et al., 2006), but also secondary injury in surviving cells through this primary event (Faden et al., 1989 ; Fujimoto et al., 2004b; Hall et al., 2005b; Marion et al., 1997). Lesions widely exist in brain tissue, such as the cerebral cortex and hippocampus, and this injury has been observed in humans (Ariza et al., 2006; Bigler et al., 1997; Isoniemi et al., 2006; Tate and Bigler, 2000; Umile et al., 2002; Wilde et al., 2007 ) and ...