Application of glibenclamide composition in preparation of medicine for treating increase of brain water content

A technology of glibenclamide and its composition, which is applied in the field of pharmaceutical use, can solve problems such as complex pathophysiological mechanisms and no treatment plan, and achieve the effects of short operation time, simple operation, and reduction of brain water content

Pending Publication Date: 2022-06-21
JIANGSU AOSAIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although a lot of human and financial resources have been invested in the research of TBI, due to its complex pathophysiological mechanism, there is no effective treatment plan so far. How to improve the survival rate of these patients and reduce the sequelae is of great significance to clinical work

Method used

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  • Application of glibenclamide composition in preparation of medicine for treating increase of brain water content
  • Application of glibenclamide composition in preparation of medicine for treating increase of brain water content
  • Application of glibenclamide composition in preparation of medicine for treating increase of brain water content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Glyburide Injection Composition (lyophilized powder for injection)

[0036] prescription:

[0037]

[0038] The preparation method is as follows: according to the prescription, dissolving anhydrous sodium carbonate and cyclodextrin in 50-70 ml of water, then adding glyburide powder, stirring and dissolving to obtain a first solution. A 2 mol / L hydrochloric acid solution was added to the first solution to adjust the pH to 8.0-8.5, and the volume was adjusted to 100 ml to obtain a second solution. The second solution is divided into vials, each vial of 3 ml, and freeze-drying is performed on the second solution in the vials to obtain freeze-dried powder injection. Freeze dry using the lyophilization procedure described in the table below.

[0039] Freeze drying procedure

[0040]

Embodiment 2

[0041] Example 2: Preparation of Glyburide Injection Composition (lyophilized powder for injection)

[0042] prescription:

[0043]

[0044] Preparation method: first dissolve anhydrous sodium carbonate and sulfobutyl ether-β-cyclodextrin in 80 ml of water, then add glyburide powder, stir and dissolve to obtain a first solution. 2 mol / L hydrochloric acid was added to the first solution to adjust the pH of the solution to 8.0-8.5, and the volume was adjusted to 100 ml to obtain a second solution. The second solution is divided into vials, each vial is 3 ml, and freeze-drying is performed on the second solution in the vials (the freeze-drying procedure is the same as that in Example 1) to obtain freeze-dried powder injection.

Embodiment 3

[0045] Example 3: Preparation of Glyburide Injection Composition (lyophilized powder for injection)

[0046] prescription:

[0047]

[0048] Preparation method: firstly dissolving meglumine and sulfobutyl ether-β-cyclodextrin in 80 ml of water, then adding glyburide powder, stirring and dissolving to obtain a first solution. 0.1M hydrochloric acid was added to the first solution to adjust the pH of the solution to 8.0-8.5, and the volume was adjusted to 100 ml to obtain a second solution. The second solution is divided into vials, each vial is 3 ml, and freeze-drying is performed on the second solution in the vials (the freeze-drying procedure is the same as that in Example 1) to obtain freeze-dried powder injection.

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PUM

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Abstract

The invention relates to the field of medicine application, in particular to application of a glibenclamide composition in preparation of a medicine for treating or preventing brain water content increase caused by traumatic brain injury, and the glibenclamide composition is a glibenclamide cyclodextrin composition for injection. Preferably, the glibenclamide and cyclodextrin composition for injection is prepared from glibenclamide, cyclodextrin and an additive, experimental results show that each dose of the glibenclamide cyclodextrin composition for injection can significantly reduce the brain water content of rats with traumatic brain injury.

Description

technical field [0001] The invention relates to the field of pharmaceutical use, in particular to the application of a glyburide composition in the preparation of a medicine for treating or preventing increased brain water content caused by traumatic brain injury. Background technique [0002] Traumatic brain injury (TBI) is a traumatic structural injury or brain dysfunction in the brain caused by external forces, which causes neurological disorders through a series of changes in neurochemical molecules and signals, resulting in patients' behavioral, cognitive and behavioral disorders. Impairment of knowledge and memory is one of the leading causes of death and disability worldwide. [0003] Although a lot of human and financial resources have been invested in the research of TBI, due to its complex pathophysiological mechanism, there is no effective treatment plan so far. How to improve the survival rate of these patients and reduce the sequelae is of great significance to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/64A61K9/19A61K9/08A61K47/40A61P25/00
CPCA61K31/64A61K9/0019A61K9/08A61K47/40A61K9/19A61P25/00
Inventor 陈虹宇宋婷婷宗在伟陈敏杨奇珍
Owner JIANGSU AOSAIKANG PHARMA CO LTD
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