A kind of brain targeting exosome, its preparation method and application

A technology of exosomes and brain, which is applied in the field of brain-targeted exosomes and its application in the treatment of brain diseases, can solve the problems of incomplete and single detection after traumatic brain injury, and achieve the goal of overcoming Difficulties in brain targeting, overcoming toxic side effects, overcoming ineffective effects
CN109701038BActive Publication Date: 2021-02-23SHANGHAI UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI UNIV
Publication Date
2021-02-23

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Abstract

The present invention discloses a brain-targeted exosome which comprises an exosome capable of passing through blood brain barrier and a fluorescent material with an imaging function, wherein the fluorescent material is distributed in the entocoele of the exosome. The invention also discloses a preparation method of the brain-targeted exosome, and the method comprises: enabling brain-targeted neural stem cells to secret an exosome with a brain-targeted peptide; collecting and purifying the exosome; and enabling the fluorescent material to enter the entocoele of the exosome so as to obtain thebrain-targeted exosome. The brain-targeted exosome provided by the present invention is mainly formed by natural materials, has a function of passing through blood brain barrier, can overcome the problem that traditional nano-particles have low efficiency of passing through blood brain barrier and have toxic or side effect, overcomes the difficulty of brain targeting of traditional particles, andprovides a visible and accurate treatment strategy for treating brain-related diseases such as traumatic brain injury and brain tumors.
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Description

technical field

[0001] The invention relates to the field of nanobiological materials, in particular to a brain-targeted exosome and its application in the treatment of brain diseases. Background technique

[0002] In recent years, Traumatic Brain Injury (Traumatic Brain Injury, TBI) has become the neurological disease second only to stroke, and has become one of the causes of death and disability worldwide. TBI is initially a primary trauma, and then over time Over time, TBI becomes a secondary brain injury, which leads to a cascade of pathophysiological responses leading to circulatory disturbance, blood-brain barrier disruption, neuronal death and subsequent neurological dysfunction after the primary injury.

[0003] Studies have shown that in addition to the traditional liposome drug-loaded treatment, exosomes are now a kind of cell vesicles with a size of 30-100nm formed by the invagination of the cell membrane, which has attracted everyone's attention. Exosomes contain...

Claims

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