4 results about "Blood pressure increase" patented technology

The invention discloses application of 9 '''-salvianolic acid B monomethyl ester in preparation of a medicine for preventing and / or treating atrial fibrillation, and belongs to the technical field of biological medicine. Experiments prove that the 9 ''-MSB disclosed by the invention can be used for remarkably improving the blood pressure rise and the atrial inner diameter increase of a mouse after Ang II perfusion; the increase of the occurrence rate and the duration time of atrial fibrillation is inhibited; macrophage infiltration, collagen deposition and oxidative stress injury of atrial tissues are reduced, and the protective effect of 9 ''-MSB is obviously superior to that of SalB. Therefore, the 9 ''-MSB can be used for preparing the medicine for preventing and / or treating the atrial fibrillation, and the invention proves that the 9''-MSB can be used as a new medicine for adjuvant treatment of the atrial fibrillation and has important clinical guiding significance.

The present Invention relates to a newly designed product, i.e. substance (B+C) that combines two different mechanisms of action that allow the control of aldosterone synthesis and secretion without compromising the metabolism of cortisol (corticosterone In rats) in the.tone glomerulosa of the adrenal gland. The innovative design of the described molecule enables ths individual use of substance (B+C) in the treatment of diseases such as hyper and hypo aldosteronism, Conn's syndrome and cytokine storm caused by Covid infection or as co-therapy with corticosteroids in the treatment of a whole range of immunological diseases. The innovative design of Substance (8+C) has an additional practical and economic advantage because the patient receives both components of substance (B+C) simultaneously with just one application, regardless of the medicine formulation. This not only simplifies the medicine synthesis, dosing and clinical research, but also the application of the medicine in clinical practice. For successful and selective control of aldosterone synthesis, which in nature also means selective control of blood pressure, it was necessary to combine the two substances described in order to ensure action in patients with elevated and / or towered blood pressure with one application of Substance (B+C). This feature of Substance (B+C) is important, especially in the treatment of patients with permanently impaired aldosterone synthesis, such as Conn's disease and similar autoimmune diseases, or in combmatton with corticosteroids where prolonged or repeated corticosteroid therapy is indicated. Finally, this invention is extremely important because It enables the safe treatment of a large group of patients with hypertension who also have secondary diseases of the immune system, various inflammations or viral Infections such as Covid where corticosteroid therapy is indicated, but difficult to implement in practice due to the negative effect of corticosteroids on blood pressure.

To provide a useful blood pressure elevation suppressant. [Solution] A blood pressure elevation inhibitor containing as an active ingredient one or more compounds selected from the group consisting of saclipin A (a compound represented by the following formula (2)), saclipin B, and derivatives thereof, isolated from an extract of Suizenji Nori. TIFF2026115124000007.tif68169

The invention discloses an application of Irisin autocrine probiotics in preparation of a medicine for preventing / treating salt-sensitive hypertension. According to the application disclosed by the invention, it is found for the first time that the probiotic B.Subtills-WB600-Irisin capable of automatically secreting Irisin protein simultaneously has the effects of preventing and treating salt-sensitive hypertension, can effectively inhibit the increase of systolic pressure and diastolic pressure induced by rats fed with high-salt diet, and can maintain the systolic pressure and diastolic pressure at a basic blood pressure level; in a Dahl-S rat model, the autotaxis Irisin probiotic treatment can improve the urine sodium excretion, so that the blood pressure rise induced by high-salt diet reverses 26 + / -8 mmHg (plt; 0.001). Compared with the traditional probiotics, the invention solves the key problems of protein stability, targeting and multi-mechanism synergy through a synthetic biological strategy, and can be used as a medicine for preventing and treating hypertension and related diseases thereof.