81 results about "Antihypertensive medication" patented technology

The invention relates to a pharmaceutical composition containing a calcium channel blocker and B vitamins. One or more of B vitamins and a pharmaceutically acceptable carrier are used. The pharmaceutical composition can improve the curative effect of calcium channel blockers and antihypertensive drugs, enhance the protective effect of calcium channel blockers on target organs, and reduce complications such as fundus hemorrhage, angina pectoris, myocardial infarction, cerebral apoplexy, heart failure, and renal failure. incidence of disease. Also provided is the application of the pharmaceutical composition in the preparation of medicines for preventing, treating and delaying hypertension complicated with hyperlipidemia. Through the implementation of the present invention, the pharmaceutical composition provided to patients not only has reliable curative effect, but also improves patient compliance, makes it convenient for patients to take medicine, reduces medical expenses, and has a good market prospect.

The invention provides a traditional Chinese medicine composition for treating hypertension insomnia, which is prepared from 10-20 parts of codonopsis pilosula, 10-20 parts of argehead atractylodes rhizom, 15-25 parts of astragalus membranaceus, 15-25 parts of dogwood, 10-20 parts of schisandra chinensis, 5-15 parts of cimicifugae foetidae, 5-15 parts of rhizoma zingiberis, 5-15 parts of cinnamon,2-10 parts of radix bupleuri and 2-10 parts of honey-fried liquorice root. The traditional Chinese medicine composition can reduce the systolic pressure and diastolic pressure levels of patients suffering from moderate hypertension and mild hypertension, and can effectively improve the sleeping state, improve the sleep quality and improve the quality of life of patients with hypertension. The invention also provides a preparation method of the traditional Chinese medicine composition for treating hypertension insomnia, and according to the preparation method, the traditional Chinese medicinecomposition can be prepared by heating and extracting the materials by taking water or ethanol with concentration of 50-95% as a solvent.

The application provides a new method for micronizing dihydropyridine antihypertensive drug raw materials, which relates to the technical field of biopharmaceutical preparations. A new method for micronizing dihydropyridine antihypertensive drug raw materials, comprising: dissolving the dihydropyridine antihypertensive drug raw materials in a first solvent, dissolving the first dihydropyridine antihypertensive drug raw materials The solvent is added to the second solvent to realize anti-solvent recrystallization of dihydropyridine antihypertensive drugs; the first solvent includes lower aliphatic alcohols or aliphatic ketones; the second solvent includes water, an aqueous solution containing electrolytes, or surfactants aqueous solution. The method can further improve the in vivo bioavailability of the oral preparations of felodipine and other dihydropyridine antihypertensive drugs.