78 results about "Antihypertensive medication" patented technology

The invention provides a pharmaceutical composition which comprises calcium channel blockers of a medicinal dose, angiotensin II receptor antagonists of a medicinal dose, one or more of B vitamins of a medicinal dose and pharmaceutically acceptable carriers, wherein the calcium channel blockers are selected from amlodipine, felodipine, israbipine, nicardipine, nifedipine, nisoldipine, nitrendipine, lacidipine, diltiazem or verapamil; the angiotensin II receptor antagonists are selected from candesartan, telmisartan, losartan, valsartan, irbesartan, eprosartan, tasosartan or olmesartan; and the B vitamins are selected from one or more of vitamin B6, vitamin B12, folic acid and calcium leucovorin. The pharmaceutical composition of the invention can improve the curative effect of the hypotensor, enhance the target organ protecting action of the hypotensor, and reduce the morbidity of complications of angina, myocardial infarction and the like.

The invention relates to a pharmaceutical composition containing one of angiotensin converting enzyme inhibitors (ACEI) and active metabolites or medical salt thereof in medicine dosage, one or more of B vitamins in medicine dosage, ginkgo biloba extracts (GbE) in medicine dosage and a medical carrier, and relates to application of the pharmaceutical composition in preparing medicines for treating, preventing or retarding stroke. The medicines prepared by the pharmaceutical composition provided by the invention are superior to the simple antihypertensive drugs in the aspect of treating, preventing or retarding stroke and facilitate the patients to take. The invention belongs to the pharmaceutical field.

A Chinese medicine for treating hypertension and preventing cerebral infarction is prepared from 17 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, red sage root, peach kernel, etc through proportioning. Its advantages are high curative effect and no by-effect.

The invention relates to a drug composition. The drug composition consists of an effective treating amount of calcium antagonist (CCB), an angiotensin II receptor blocker (ARB), a thiazide diuretic, a folic acid compound and a pharmaceutically acceptable carrier, wherein the content of the CCB is 2-240 mg, the content of the ARB is 4-600 mg, the content of the thiazide diuretic is 0.625-25 mg, and the content of the folic acid compound is 0.4-0.4 mg. The drug composition has the advantages that the drug composition can effectively improve the treatment effect of reducing blood pressure of class-2 and class-3 hypertensive patients, strengthen the effect of protecting target organs of the patients and reduce the occurrence risk of cerebral apoplexy complications caused by high blood pressure. In addition, the drug composition can be conveniently taken by patients, the treatment compliance is greatly improved, and the medical costs can be also reduced.

The present invention relates to an antihypertensive agent including a boysenberry seed extract as an active ingredient. According to the invention, there can be provided an effective and highly safe antihypertensive agent having antihypertensive effect so that the agent can contribute to the prevention and amelioration of hypertension and having very little risk of side effects even in continuous intake, and a method for producing the antihypertensive agent at low cost and efficiently.

A hypoglycemic and antihypertensive medicine is prepared from corn tassel, carrot and white gourd peel. Its advantages are widely available raw materials, high curative effect and no by-effect.

The invention provides a biodegradable subcutaneous implant rod used for long-acting pressure reduction. The biodegradable subcutaneous implant rod is a cylindrical implant rod prepared by mixing an antihypertensive drug with a biodegradable material--modified poly(glycerol-sebacate) which is used as a carrier. The implant rod is implanted into subcutaneous tissue of the human body after cobalt 60 irradiation sterilization; through slow degradation of modified poly(glycerol-sebacate), the drug is released, enters blood circulation and performs the effect of a pharmacological antihypertensive drug, and effective plasma concentration is guaranteed so as to achieve the purposes of long-term blood pressure reduction and blood pressure stabilization. The implant rod is totally degraded in one to two years, the drug is totally released at the same time, the implant rod turns into carbon dioxide, nitrogen, water and a few amount of glycerin which are absorbed by the human body and are then discharged out from the human body, so a treatment course of slow release administration is completed. The biodegradable subcutaneous implant rod can substantially reduce the attack rate of sudden cardio-cerebrovascular emergencies due to a patient misses a dose of a drug; and according to results of clinical verification, the biodegradable subcutaneous implant rod has an effective rate of 100% on primary hypertension adaptation diseases.

The invention is a medicine pillow for reducing one's blood pressure, made by composed of special herbal medicine produced in Guizhou and composed of pillowslip and pillow core. The pillow core consists of pillow cushion and medicine bag, the pillow crushion able to be made by animal pair, or cotton fibre, or synthetic fiber or other plant fiber and the medicine bag packing with: celery root 150-200 shares (quality, same to the following), carpinus turcazninowii 100-150 shares, cogongrass rhizome 100-150 shares, mother chrysanthemum 100-150 shares and gypsum powder 500 shares. It can be widely used in treatment and health cure of the hypertension.

The invention relates to a beta-adrenergic receptor retarder (short for beta receptor retarder) and vitamins B-containing pharmaceutical composition which comprises effective treatment quantity of one of beta receptor retarder and an active metabolite or salt thereof, effective treatment quantity of one or more of vitamins B, and a pharmaceutically acceptable carrier, wherein the content of the beta receptor retarder and the active metabolite or salt thereof is 2.5-200mg, and the content of vitamins B is 0.1-50mg. The beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition has the advantages that with the pharmaceutical composition, the curative effect of the beta receptor retarder on reducing the blood pressure can be enhanced, the target organ protection role of the beta receptor retarder hypotensive drugs can be enhanced, and the occurrence rate of complications such as left ventricular hypertrophy, coronary heart disease, heart failure, cerebral apoplexy, renal lesions, renal insufficiency and the like can be reduced. In addition, the pharmaceutical composition can enable patients to take conveniently, and the medical cost can be lowered.

The invention discloses a method for detecting genes affecting the efficacy of antihypertensive drugs by combining a TaqMan-MGB probe and a real-time fluorescence quantitative PCR technique. The polymorphism of the genes affecting the efficacy of the antihypertensive drugs in samples to be detected is detected, five SNP loci can be detected simultaneously, used primers and the TaqMan-MGB probe have high specificity, the risk of false positive caused by PCR product contamination can be reduced, the operation is simple and the result is accurate and reliable. According to the method, functionalmeaningful mutations such as NEDD4L-326G>A(rs4149601), AGTR1 1186A>C(rs5186), ACE I/D(rs1799752), ADRB1 1165G>C(rs1801253) and CYP3A5*3(rs776746) are detected to assist clinicians to select appropriate drugs and doses or avoid occurring of drug interactions, the best therapeutic effect for patients is achieved, and thus the purpose of real ''individualized medication'' is achieved.

The invention relates to a synergistic antihypertensive lipid-lowering pharmaceutical composition and the use of the pharmaceutical composition. The pharmaceutical composition comprises a pharmaceutical dosage of one of HMG-CoA reductase inhibitors, a pharmaceutical dosage of one of antihypertensive drugs, aspirin, folic acid and 5-methylaretetrahydrofolate, and a pharmaceutically acceptable carrier. The indication is hypertension accompanied with hyperlipidemia. The pharmaceutical composition can also be used as a primary drug for prevention of cardiovascular diseases. By the implementation of the invention, the pharmaceutical composition for the specific use for patients can improve the compliance of the patients, facilitate administration of the patients and reduce medical expenses, so that the pharmaceutical composition has relatively good market prospects.

The invention discloses an ACE inhibitory peptide and a synthesis method and application thereof. The ACE inhibitory peptide is artificially synthesized by means of an Aapptec396 automatic peptide synthesizer and by means of an Fmoc solid-phase synthesis method, the amino acid sequence of the ACE inhibitory peptide is Gly-Pro-Leu-Gly-Val-Pro, and it is found through detection that the IC50 value of the ACE inhibitory peptide is 105.8 mu M (P is smaller than 0.05), so that the ACE inhibitory peptide is a better-activity ACE inhibitor and can be used for preparing antihypertensive drugs.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a compound antihypertensive pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition of allisartan medoxomil and/or salt thereof and indapamide and a preparation method thereof.

The invention provides an antihypertensive drug and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The antihypertensive drug comprises the following components in parts by weight: 10-30 parts of uncaria, 15-30 parts of selfheal, 15-25 parts of ligusticum wallichii, 10-25 parts of saponin, 12-24 parts of folium mori and 18-28 parts of radix puerariae. The preparation method of the antihypertensive medicine comprises the following steps: grinding the raw materials into powder to obtain medicine powder, adding water into the medicine powder, and decocting to obtain liquid medicine. The antihypertensive drug can improve and prevent hypertension, and is safe in action mode and free of side effects. The preparation method of the antihypertensive drug is simple and rapid, convenient to use and suitable for batch production.

The invention belongs to the technical field of medicines, and relates to a compound antihypertensive drug composition. The composition is a compound bilayer tablet containing atenolol and amlodipine, wherein the first layer of tablet contains effective dosage (12.5mg) of atenolol; and the second layer of tablet contains effective dosage (2.5mg) of amlodipine. The preparation can be evenly and effectively dissolved, is good in stability, and has good clinical effect and low adverse effect rate.