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Medicinal composition contaniing angiotensin invertase inhibitor and vitamin B

A technology of B vitamins and angiotensin is applied in the field of chemical pharmaceutical compositions for treating, preventing or delaying hypertension and related diseases, and can solve the problems of insignificant curative effect and the like

Active Publication Date: 2006-08-16
SHENZHEN AUSA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are still some problems in the clinical application of ACEI antihypertensive drugs. First, their antihypertensive efficacy has a certain limit. A large number of literature reports have a total effective rate of only about 60%, and 40% are ineffective or have no significant curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1. preparation of pharmaceutical composition

[0051] prescription

[0052] Enalapril maleate 5.0g (based on enalapril maleate)

[0053] Folic acid 0.2g

[0054] Starch 45.0g

[0055] Microcrystalline Cellulose 45.0g

[0056] Sodium carboxymethyl starch (CMS Na) 5.0g

[0057] 5% povidone k-30 (solvent is absolute ethanol) QS

[0058] Magnesium stearate (MS) QS

[0059] Made into 1000 pieces

[0060] Preparation Process:

[0061] (1) Take the prescribed amount of enalapril maleate and folic acid and pass through a 100-mesh sieve and mix them uniformly by the method of equal increments for subsequent use;

[0062] (2) Other auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0063] (3) Mix the starch, microcrystalline cellulose, and CMS Na according to the prescription amount and then mix them evenly with the raw material medicine that has been mixed;

[0064] (4) Add appropriate a...

Embodiment 2

[0066] Embodiment 2. preparation of pharmaceutical composition

[0067] prescription

[0068] Enalapril maleate 10.0g (based on enalapril maleate)

[0069] Folic acid 0.8g

[0070] Starch 45.0g

[0071] Microcrystalline Cellulose 45.0g

[0072] Sodium carboxymethyl starch (CMS Na) 5.0g

[0073] 5% povidone k-30 (solvent is absolute ethanol) QS

[0074] Magnesium stearate (MS) QS

[0075] Made into 1000 pieces

[0076] Preparation Process:

[0077] (1) Take the prescribed amount of enalapril maleate and folic acid and pass through a 100-mesh sieve and mix them uniformly by the method of equal increments for subsequent use;

[0078] (2) Other auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0079] (3) Mix the starch, microcrystalline cellulose, and CMS Na according to the prescription amount and then mix them evenly with the raw material medicine that has been mixed;

[0080] (4) Add appropria...

Embodiment 3

[0082] Embodiment 3. preparation of pharmaceutical composition

[0083] prescription:

[0084] Benazepril hydrochloride 10.0g (Benazepril hydrochloride meter)

[0085] Folic acid 0.4g

[0086] Starch 45.0g

[0087] Microcrystalline Cellulose 35.0g

[0088] Sodium carboxymethyl starch (CMS Na) 5.0g

[0089] 5% povidone k-30 (solvent is absolute ethanol) QS

[0090] Magnesium stearate (MS) QS

[0091] Made into 1000 pieces

[0092] Preparation Process:

[0093] (1) Take the prescription amount of benazepril hydrochloride and folic acid and pass through a 100 mesh sieve and mix them uniformly by the method of increasing in equal amounts for subsequent use;

[0094] (2) Other auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0095] (3) Mix the starch, microcrystalline cellulose, and CMS Na according to the prescription amount and then mix them evenly with the raw material medicine that has been mixed; ...

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PUM

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Abstract

The medicine composition consists of one of ACE1, its active metabolism product and salt in treating effective amount of 0.5-100 mg, one or several kinds one B family vitamins in treating effective amount of 0.1-50 mg, and pharmaceutically acceptable carrier. The medicine composition of the present invention has the advantages of raising the treating effect of blood pressure lowering ACE1 medicine, strengthening the protecting effect of blood pressure lowering ACE1 medicine on target organ and reducing the incidence rate of hemorrhage of the ocular fundus, angina pectoris, myocardial infarction and other complications.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing an angiotensin-converting enzyme inhibitor and B vitamins, especially a chemical medicine composition for treating, preventing or delaying hypertension and related diseases, and belongs to the field of pharmacy. Background technique [0002] Essential hypertension is one of the most common chronic diseases and is the main cause of serious cardiovascular diseases such as myocardial infarction, stroke, and kidney disease. The prevalence rate of hypertension in my country is 27.2%, and there are more than 130 million patients at present, and the prevalence rate of hypertension is increasing rapidly (compared with the survey in 1991), and the growth rate of the prevalence rate of hypertension among people aged 35 to 44 74% for men and 62% for women (Gu Dongfeng, Jiang He, Wu Xigui, et al. Prevalence, awareness, treatment and control of hypertension in Chinese adults. Chinese Journal of Prevent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/675A61P9/12C07F9/6584
Inventor 陈光亮王琳琳李莉段炎炎徐希平
Owner SHENZHEN AUSA PHARM CO LTD
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