39 results about "Enalapril Maleate" patented technology

The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the preparation of stable formulations of ACE inhibitors, especially enalapril maleate.

The invention discloses an enalapril maleate tablet and a preparation method thereof, belonging to the technical field of chemical pharmaceutical industry. The enalapril maleate tablet mainly contains 3 to 9 parts of enalapril maleate, 40 to 60 parts of filling agent, 0 to 35 parts of disintegrating agent, 0 to 2 parts of caking agent, 0.1 to 4 parts of lubricating agent and 0.1 to 3 parts of flow aid. Compared with the conventional merchant enalapril maleate tablet, the enalapril maleate table provided by the invention adopts auxiliary materials which have poorer compatibility with the enalapril maleate technical on the traditional conception and ensures that the enalapril maleate tablet produced by using common auxiliary materials has excellent stability by utilizing the specified proportions among raw and auxiliary materials and the specific preparation process; and after being detected, the material qualities of batches of products are all not more than 3.0 percent, the quality stability thereof is superior to the same product from other enterprises, and the cost is saved to the largest extent at the same time of improving the stability.

The invention relates to a medicinal composition containing Enalapril or Enalapril-acid addition salt and Felodipine, prepared by putting slow-release pellets containing Felodipine and quick-release pellets containing Enalapril or Enalapril-acid addition salt in capsules. Each dosage unit of the medicinal composition contains 2.5-25mg of Enalapril maleate and 2.5-25mg of Felodipine. The medicinal composition can stabilize blood pressure quickly, and keep effective blood concentration for 24 hours, with increasing patient compliance. The medicinal composition is administered only once a day.

The invention relates to stable enalapril maleate capsules and a preparation method thereof, and belongs to the technical field of medicine. Enalapril maleate, lactose monohydrate, microcrystalline cellulose, startch, hydroxypropyl methyl cellulose, sodium alga acid, poloxamer 407, polyethylene glycol 4000 and L-arginine are preferably used as medical components of the stable enalapril maleate capsules, the degradation speed of the enalapril maleate is remarkably decreased through the mutual synergistic effect, the stability of the enalapril maleate capsules is greatly improved, and it is ensured that clinical medicine is safe, effective and capable of being stored for a long time.

The invention provides a new Enalapril maleate and folic acid composite preparation. An acid stabilizer with weight ratio of 1%-5% is added in the preparation to improve the stability of the preparation at high temperature and long-term standing condition; and meanwhile, a mixture of microcrystalline cellulose and lactose monohydrate is selected asfiller, the dissolution of the folic acid in the 0.1M hydrochloric acid medium is improved, and a finally prepared tablet is basically consistent with the market tablet. The composition disclosed by the invention is good in stability, capable of guaranteeing the clinical safe use of the medicine, simple in process operation, and suitable for industrial production.

The invention discloses enalapril maleate granules and aims to provide a granule prescription which can improve the drug stability. The enalapril maleate granules prepared by the method have the advantages that the enalapril maleate granules can be directly swallowed and can be further mixed in water to drink and can be quickly dissolved when coming across water; the enalapril maleate granules are good in taste, convenient to apply and carry, accurate to quantify, quick to take effect and high in availability. Meanwhile, the invention further discloses a preparation method of the enalapril maleate granules. By adopting a cyclodextrin inclusion technique, medicinal raw materials are included by virtue of a saturated aqueous solution method, so that the drug stability is improved. The process is simple to operate and low in cost, and the industrial amplifying application is increased.

The invention provides isomer impurities in bulk pharmaceutical chemicals of enalapril maleate and a preparing method of the isomer impurities. N-t-butyloxycarboryl-D-alanine (a compound I) and D-proline benzyl ester (II) are subjected to a condensation acylation reaction to prepare an intermediate compound III, then Boc deprotection is conducted to obtain an intermediate compound IV, the intermediate IV and ethyl 2-oxo-4-phenylbutyrate (V) are subjected to reductive amination to obtain a compound VI, then the compound VI is subjected to hydrogenation to remove benzyl groups, then a mixture ofenalapril enantiomers (TM1) and diastereoisomers (TM2), and then the enalapril enantiomers (TM1) and diastereoisomers (TM2) are obtained through preparative chromatographic separation.

The invention discloses a stable enalapril maleate tablet and a preparation method thereof, and belongs to the technical field of the pharmaceutic preparation. The enalapril maleate tablet is prepared by the following components by weight: 0.255-1.02 parts of enalapril maleate, 7-9 parts of lactose, 0.6-1.8 parts of corn starch, 0.1-0.3 parts of glycerol distearate, and 0.1-0.2 parts of lake or ferric oxide. The selected accessories and the preparation technology are capable of remarkably reducing the degrading speed of the enalapril maleate through the mutual synergistic effect, greatly improving the stability of the enalapril maleate tablet product, and solving the quality problem existing in the current product all the time. The lake or ferric oxide is added in the tablet for the good shading function, so the enalapril maleate photosensitivity problem can be effectively solved.

The present invention provides storage-stable and bio-stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride, that can be manufactured in a time efficient and cost effective manner. Such formulations can be prepared simply and on a large industrial scale using conventional methods and equipment. The present invention also provides methods for the preparation of highly manufacturable, storage-stable and bio-stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride. Methods for treatment of cardiovascular disorders using storage-stable and bio-stable formulations of ACE inhibitors, especially enalapril maleate and quinapril hydrochloride, are also provided.

The invention provides a pharmaceutical composition for treating hypertension. The invention relates to a pharmaceutical composition comprising therapeutic doses of lercanidipine hydrochloride and enalapril maleate, and a proper amount of oil, a surfactant and an assisted surfactant. Preparative dosage forms particularly hard capsules and soft capsules are provided. The pharmaceutical composition increases solubility of a poorly soluble drug of lercanidipine hydrochloride and stability of enalapril maleate, and is suitable for the treatment of hypertension.

The invention discloses a preparation method of enalapril maleate. The preparation method comprises the following steps of adding L-alanine, alkali and water into a container, cooling, adding a (Boc)2O solution, performing heating, stirring and reacting to obtain an intermediate 1; adding the intermediate 1 into a solvent, cooling, adding a chlorination reagent under the protection of nitrogen, and performing stirring for reaction to obtain an intermediate 2; adding L-proline and alkali into water for reaction, then adding the intermediate 2, and carrying out heat preservation reaction to obtain an intermediate 3; adding 2-oxo-4-phenyl ethyl butyrate, the intermediate 3, a molecular sieve and a reducing agent into a solvent, and reacting under set pressure to obtain an enalapril crude product; and dissolving the enalapril crude product, adding maleic acid, and stirring for reaction to obtain enalapril maleate. The method has the advantages of safe and easily available starting materials, low price, relatively short reaction steps, avoidance of the use of toxic reagents, relatively small generation amount of three wastes, relatively simple operation, high product purity, high yield, and suitableness for industrial production.

The invention relates to a drug composition for treating chronic cardiac failure and application thereof. The drug composition comprises a traditional Chinese medicine composition, Enalapril Maleate-Folate tablets and metoprolol tablets. The traditional Chinese medicine composition is prepared from rehmannia roots, radix aconiti lateralis preparata, cassia twigs, radix ophiopogonis, Chinese yam, dogwood, the fruit of Chinese magnoliavine, Codonopsis pilosula, white poria and rhizoma alismatis. The invention further provides application of the traditional Chinese medicine for preparing medicinefor treating chronic cardiac failure. The drug composition has the advantages that the selected traditional Chinese medicines and the ratio are carefully screened, and the effect is remarkable; the preparation method is simple, and the drug composition is convenient for a patient to use; the drug effect is high, no toxic or side effect is caused, no adverse reaction is caused, the clinical symptoms of the patient suffering from chronic cardiac failure can be obviously improved, the heart rate variability of the patient is regulated, the good clinic effect is achieved, and the good applicationprospect is achieved.

The invention relates to a method for treating diabetes by combining traditional Chinese medicine and western medicine. The method specifically comprises the following steps: (1) general treatment; (2) western medicine treatment, namely, controlling blood glucose and blood pressure, and controlling the blood glucose through gliquidone tablets; treating severe patients by cooperatively using insulin; reducing the blood pressure through enalapril maleate tablets; dosing albumin intravenous drip to patients suffering hypoproteinemia, oliguria and severe edema and treating by utilizing equilibrium liquid; and (3) traditional Chinese medicine treatment method, namely mixing 2-5 parts of ginseng, 3-5 parts of lucid ganoderma, 2-5 parts of astragalus root, 4-8 parts of wine-treated rhubarb, 6-9 parts of yam, 3-5 parts of cornus, 4-8 parts of radix rehmanniae, 1-3 parts of leech, 3-5 parts of safflower, 5-8 parts of salviae miltiorrhizae, 10-20 parts of rhizoma smilacis glabrae, 2-6 parts of rhizoma alismatis and 1-4 parts of licorice to a traditional Chinese medicine decoction, and decocting the traditional Chinese medicine in water when in use. The traditional Chinese medicine formulation has the functions of invigorating qi, tonifying kidney, detoxifying, promoting diuresis, promoting blood circulation to remove meridian obstruction, strengthening body resistance and eliminating evil, and the combined treatment manner has a certain curative effect on diabetics.

The invention provides enalapril maleate capsules and a preparation method thereof. The enalapril maleate capsules comprise the following raw and auxiliary materials in parts by weight: 3-5 parts of enalapril maleate, 60-80 parts of filler, 0.2-3 parts of zinc stearate and 1-3 parts of glycerol distearate. The preparation method comprises the following steps: 1) uniformly mixing enalapril maleate and the filler in an equivalently increasingly adding manner, and screening the mixture through a 100-mesh sieve for later use; and 2) uniformly mixing the powder obtained in the step 1) with zinc stearate and glycerol distearate in prescription amounts in an equivalently increasingly adding manner, screening the mixture through a 100-mesh sieve, and tabletting the dry powder to obtain the enalapril maleate capsules. The capsules prepared from simple raw and auxiliary materials are high in stability and high in dissolving rate.

The invention relates to a method for preparing enalapril maleate tablets, and belongs to the field of pharmaceutical preparations. The method for preparing the stable enalapril maleate tablets is discovered pertinently for the problems of increase of related substances in enalapril maleate tablet long-term storage procedures and instable quality of products. The method for preparing the enalaprilmaleate tablets has the advantages that the method is simple, industrial production can be facilitated, and the quality of products can be guaranteed.