Preparation method of N-carboxyalkyl dipeptide type angiotensin converting enzyme inhibitor
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI INST OF PHARMA IND CO LTD
- Publication Date
- 2003-07-16
- Estimated Expiration
- Not applicable · inactive patent
Abstract
Description
technical field
[0001] The invention relates to a preparation method of an angiotensin-converting enzyme (ACE) inhibitor of N-carboxyalkyl dipeptide structure type. Background technique
[0002] N-carboxyalkyl dipeptide structure type Angiotensin-converting enzyme (ACE) inhibitors are a class of safe and effective drugs for the treatment of hypertension and congestive heart failure, including enalapril maleate and lisinopril, which are best-selling in the world Drugs play an important role in cardiovascular drugs. Its structural general formula is as follows: where: R 1 =C 3 h 7 -; R 2 =CH 3 -; CF 3 CONH(CH 2 ) 3 CH 2 -; NH 2 (CH 2 ) 3 CH 2 -R 3 = H, C 2 h 5
[0003] Existing many patent literatures have reported the preparation method of this type of medicine at present, as: reports such as Jerry WSkiles (Organic Preparations and Procedures International, 1988,20 (2): 109-115) by first preparing N-carboxylic anhydride (N-CarboxyAnhydride, NCA), the...