Preparation method for enalapril maleate orally disintegrating tablets

A technology of enalapril maleate and orally disintegrating tablets is applied in the field of preparation of enalapril maleate orally disintegrating tablets, which can solve problems such as slow onset of action, achieve fast onset of action, improve absorption and Bioavailability, energy saving effect

Active Publication Date: 2013-11-20
青岛国海生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the enalapril maleate preparations on the domestic market are ordinary tablets and hard capsules, and the onset of action is slow

Method used

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  • Preparation method for enalapril maleate orally disintegrating tablets
  • Preparation method for enalapril maleate orally disintegrating tablets
  • Preparation method for enalapril maleate orally disintegrating tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation of Enalapril Maleate Orally Disintegrating Tablets

[0022] Prescription 1:

[0023]

[0024] Preparation method: Enalapril maleate is pulverized with a micronizer, and about 90% of the particles have a particle size of less than 80 μm. Then add diluent, part of disintegrant, corrective agent and mix evenly, carry out dry granulation, then add part of disintegrant and lubricant for total mixing, tablet compression, the specification is 10mg / tablet.

Embodiment 2

[0025] Embodiment 2: Preparation of enalapril maleate orally disintegrating tablets

[0026] Prescription 2:

[0027]

[0028] Preparation method: same as Example 1, the specification is 10mg / tablet.

Embodiment 3

[0029] Example 3: Preparation of Enalapril Maleate Orally Disintegrating Tablets

[0030] Prescription 3:

[0031]

[0032]

[0033] Preparation method: same as Example 1, the specification is 10mg / tablet.

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Abstract

The invention relates to a preparation method for enalapril maleate orally disintegrating tablets. The formula comprises the following ingredients, by weight, enalapril maleate, diluents, disintegrating agents, lubricants and corrective agents with a ratio of 1:(5-6):(3.5-4.5):(0.1-0.3):(0.05-0.15). The diluents, the disintegrating agents, the lubricants and the corrective agents can be substances generally used in pharmaceutical field. Enalapril maleate is crushed by a micropowder machine, and the particle sizes of 90% of the particles are less than 80 microns. Then the diluents, part of the disintegrating agents, the corrective agents are added, mixed uniformly and subjected to dry granulation. Then part of the disintegrating agents, the lubricants are added, mixed totally, and subjected to tabletting, and enalapril maleate orally disintegrating tablets are obtained. The enalapril maleate orally disintegrating tablets are advantaged by rapid disintegration, rapid onset, high absorption and high bioavailability. The enalapril maleate orally disintegrating tablets can reduce irritation effects of medicines on oesophaguses and gastrointestinal tracts and are well suitable for some critical patients to take.

Description

Technical field: [0001] The invention relates to a preparation method of rapidly disintegrating enalapril maleate orally disintegrating tablets, belonging to the field of pharmaceutical preparations. Background technique: [0002] Hypertension is a clinical syndrome mainly manifested by elevated systemic arterial pressure and peripheral arteriolar resistance accompanied by varying degrees of increased cardiac output and blood volume. Clinically, it can be divided into two categories: primary and secondary. The cause of the disease is unknown, called essential hypertension, also known as hypertension. It is a common cardiovascular disease related to genetics and environment that can lead to pathological damage and dysfunction of target organs such as the heart, brain, kidney, peripheral blood vessels, and fundus. It accounts for more than 90% of all hypertensive patients. [0003] Antihypertensive drugs are divided into 6 categories according to the Chinese guidelines for h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/40A61K47/38A61P9/12A61P13/12A61P9/04
Inventor 顾春艳孙雪燕朱燕玲
Owner 青岛国海生物制药有限公司
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