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Composition of polydextrose and calcium ion antagonist and application thereof

A technology of calcium ion antagonist and polydextrose, which is applied in the field of the composition of polydextrose and calcium ion antagonist, can solve the problems of increased osmotic pressure, does not involve the direct interaction between PDX and intestinal mucosal cells, etc., and achieves good application. Prospects, the effect of solving the side effects of constipation

Inactive Publication Date: 2019-08-30
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, PDX is mostly used as dietary fiber, which is not completely absorbed by the intestine, and the osmotic pressure in the intestine increases to explain the enhanced gastrointestinal motility after taking PDX, or it is believed that PDX can balance the intestinal flora to produce and regulate the gastrointestinal tract. Exercise, but does not convincingly explain diarrhea and constipation after taking PDX
From the above studies, it can be seen that there is no direct interaction between PDX and intestinal mucosal cells, regardless of osmotic pressure or microbial flora balance. Therefore, if the role of dietary fiber on gastrointestinal mucosal cells can be clarified The target of action has theoretical and practical value for guiding the standardized use of PDX

Method used

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  • Composition of polydextrose and calcium ion antagonist and application thereof
  • Composition of polydextrose and calcium ion antagonist and application thereof
  • Composition of polydextrose and calcium ion antagonist and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composition of polydextrose and calcium ion antagonist in this embodiment, the mass ratio of polydextrose to calcium ion antagonist is 20:1-5:1;

[0032] The calcium ion antagonist is any one of nifedipine, amlodipine, and felodipine.

Embodiment 2

[0034] The difference between this example and Example 1 is that the mass ratio of polydextrose to calcium ion antagonist is 10:1.

[0035] The action mechanism of the composition of this embodiment is to activate the calcium ion channel on the mucosa of the small intestine, and promote the influx of calcium ions to generate excitatory effect on the small intestine.

Embodiment 3

[0037] Effects of PDX on small intestinal motility in normal mice

[0038] 3.1 Experimental materials

[0039] PDX (batch number: F2017112053112, Guangzhou Huijian Biotechnology Co., Ltd.)

[0040] 3.2 Experimental animals

[0041] Kunming mice, weighing 18-22g, male or female (Jinan Pengyue Experimental Animal Breeding Co., Ltd.), license number: SCXK (Lu) 20140007.

[0042] 3.3 Experimental method

[0043]The mice were adaptively fed for one week and randomly divided into 8 groups: ① blank group, ② PDX (10 mg / kg), ③ PDX (20 mg / kg), ④ PDX (50 mg / kg), ⑤ PDX (100 mg / kg), ⑥ PDX (150 mg / kg ), ⑦PDX (200mg / kg), ⑧PDX (250mg / kg), wherein mg / kg represents the dose per kilogram of body weight of the animal, 10 in each group, half male and half male. Each mouse was intragastrically administered with a volume of 0.2ml, the blank group was administered with ink, and the other groups were administered with ink containing a corresponding amount of PDX. After 15 minutes, the mice were s...

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Abstract

The invention relates to a composition of polydextrose and a calcium ion antagonist, which can reduce the side effect of constipation caused by taking antihypertensive drugs by using polydextrose which is not absorbed by the intestine while reducing blood pressure by the calcium ion antagonist, and belongs to the technical field of compositions of polydextrose and a calcium ion antagonist and application thereof. According to the composition of polydextrose and a calcium ion antagonist, the mass ratio of the polydextrose to the calcium ion antagonist is from (20:1) to (5:1). The composition ofthe polydextrose and a calcium ion antagonist of the invention can solve the side effect of constipation caused by long-term use of the calcium ion antagonist, the latest action mechanism of the action is revealed, and the optimal combination ratio of the polydextrose and the calcium ion antagonist is provided; good application prospects are obtained.

Description

technical field [0001] The invention relates to a composition of polydextrose and a calcium ion antagonist, which can alleviate the constipation caused by taking antihypertensive drugs while lowering blood pressure, and belongs to the composition of polydextrose and calcium ion antagonist and its application technology field. Background technique [0002] Calcium ion antagonists such as nifedipine, amlodipine, and felodipine are commonly used "dipine" antihypertensive drugs, which belong to one of the five categories of drugs recommended in the "Guidelines for the Prevention and Treatment of Hypertension in China" in 2018 . Calcium ion antagonists such as nifedipine can prevent calcium ions from entering the myocardium or vascular smooth muscle cells, causing a decrease in the tension of blood vessels around the body and coronary arteries, resulting in a decrease in blood pressure and an increase in coronary blood flow. Some patients may experience constipation when taking...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61K31/4422A61P9/12A61P1/10
CPCA61K31/4422A61K31/716A61P1/10A61P9/12A61K2300/00
Inventor 柳全文王晓洁吕晓文肖波
Owner LUDONG UNIVERSITY
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