14 results about "Small intestinal motility" patented technology

The invention discloses bifidobacterium longum subsp. Infantis for regulating intestinal motility and aquaporin and application of the bifidobacterium longum subsp. Infantis, and belongs to the technical field of microorganisms. According to the invention, the bifidobacterium longum subsp. Infantis CCFM1269 is screened, and the bifidobacterium longum subsp. Infantis CCFM1269 has the effects of intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention provides a traditional Chinese medicine composition for improving spleen and stomach health and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 30 parts of rhizoma dioscoreae, 15 to 20 parts of rhizoma atractylodis macrocephalae, 8 to 15 parts of fructus aurantii, 10 to 15 parts of red dates, 8 to 12 parts of liquorice root, 10 to 15 parts of inulin, 6 to 10 parts of fructus amomi and 5 to 8 parts of cassia twig. The lauric acid modified fenugreek gum (LA-FG) is used as an emulsifier and an immobilized enzyme carrier to construct a water-oil two-phase enzymolysis system, so that the content of effective active ingredients in the traditional Chinese medicine composition, the product stability and the bioavailability are remarkably improved. In addition, the traditional Chinese medicine composition can effectively improve the gastric emptying rate and the small intestine propulsion rate, the level of motilin and anti-inflammatory factors IL-10 is improved, and the effect of improving spleen and stomach health is achieved through multi-target-point synergism. The method successfully breaks through double limitations of a traditional process and an existing scheme, effectively considers volatile oil protection, efficient enzymatic conversion and system stability, and provides a new path for promoting technical upgrading of the traditional Chinese medicine industry.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for treating liver depression and spleen deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from codonopsis pilosula, rhizoma atractylodis macrocephalae stir-fried with bran, radix bupleuri, stir-fried radix paeoniae alba, pericarpium citri reticulatae, fructus aurantii stir-fried with bran, ginger processed pinellia, radix salviae miltiorrhizae, medicated leaven, stir-fried endothelium corneum gigeriae galli and fingered citron according to The traditional Chinese medicine composition is based on the theory of inhibiting wood and supporting soil in traditional Chinese medicine, and all the components have a synergistic effect and have the effects of soothing the liver, relieving depression, strengthening the spleen and harmonizing the stomach. Animal experiments prove that the traditional Chinese medicine composition provided by the invention can significantly improve the gastric emptying rate and the small intestine propulsion rate of a chronic gastritis model, and can down-regulate the gene expression of gastric mucosa intestinal metaplasia related markers CDX2 and MUC2.

The application provides application of Lactobacillus paracasei K56 in preparation of products for improving intestinal peristalsis and promoting defecation, and relates to the technical field of biotechnology. The application comprises application of Lactobacillus paracasei K56 in preparation of products containing at least one efficacy of improving small intestinal propulsion rate of a subject, promoting intestinal peristalsis of the subject and promoting defecation of the subject, wherein the products comprise a fermentation product fermented by using a fermenting agent containing Lactobacillus paracasei K56, and the fermentation substrate contains milk; and the application comprises increasing the proportion of the number of dead Lactobacillus paracasei K56 cells in the fermented product relative to the total number of Lactobacillus paracasei K56 cells. The application alleviates the technical problem that inactivation of bacteria in a fermented product causes the probiotic function to be affected.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a preparation method of a probiotic fermented traditional Chinese medicine preparation, which comprises the following steps: carrying out aerobic fermentation on part of traditional Chinese medicine raw materials to obtain aerobic fermentation liquor and aerobic fermentation residues; performing anaerobic fermentation on the other part of the traditional Chinese medicine raw materials to obtain anaerobic fermentation liquid and anaerobic fermentation residues; mixing the aerobic and anaerobic fermentation residues and carrying out solid-state fermentation to prepare functional mycoplasm; and mixing the aerobic and anaerobic fermentation broth with the functional mycoplasm to obtain the microbial inoculum. According to the preparation method, a segmented fermentation process is combined with a fermentation inducer compounded by tea polyphenol and yeast extract, so that the problems of poor taste and low utilization rate of active ingredients of a traditional Chinese medicine preparation are effectively solved. The probiotic fermented traditional Chinese medicine preparation prepared by the preparation method disclosed by the invention is mellow in taste, palatable in sourness and sweetness and high in utilization rate of active ingredients, has the effects of strengthening the spleen and stomach and promoting digestion and removing food stagnation, and can be used for remarkably improving the gastrointestinal function, effectively reducing gastric emptying hysteresis and improving the small intestine propulsion capability and the overall gastrointestinal digestion capability.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The invention discloses an agaro-oligosaccharide oral solution with a constipation relieving function, and belongs to the technical field of food biology. The invention provides a preparation method of agarotriose. Main components which mainly exert anti-inflammatory activity are analyzed through clinical evaluation. According to the invention, agarotriose is extracted by adopting an enzymolysis method to treat LOP-induced constipation mice, and the influence of main components on model mice is investigated from the aspects of excrement water content, small intestine propulsion rate, first-grain black excrement discharge time, colon pathological structure and the like. Experimental results show that compared with an LOP group, the agarotriose high-dose group can significantly improve constipation symptoms, relieve inflammatory response and promote colonic mucosa repair, so that agarotriose can be used as a good functional food for relieving constipation.

The application provides a kind of Huayu Xiaoshi medicinal composition and its preparation method and application, the composition is made of Huangqi 8-12 parts, Danggui 1-3 parts, Juhong 18-22 parts, Doukou 10-20 parts, Gancao 8-12 parts, lemon 8-12 parts, Shanzha 1-3 parts, fine corn powder 46-50 parts, gradient drying, grading ultrafine grinding, constant temperature and humidity mixing process is used to prepare.The application constructs the collaborative system of tonifying qi-blood-activating blood and food digestion, promotes the small intestine propulsion rate of food accumulation and blood stasis model rats, is safe and non-toxic, can be made into various oral preparations, adopts gradient drying, grading ultrafine grinding, constant temperature and humidity three-dimensional mixing process, maximally retains Doukou volatile oil, lemon vitamin C and other heat-sensitive effective components, and is used for the treatment of food accumulation and blood stasis.

The invention discloses bifidobacterium bifidum capable of relieving postpartum constipation of a mother generation and food allergy of a child generation and application of the bifidobacterium bifidum, and belongs to the field of microorganisms. A strain of bifidobacterium bifidum CCFM1523 is screened out, postpartum constipation of female rats is relieved, specifically, the number and weight of black excrement grains in 5 h and the small intestine propulsion rate can be increased, and the first black excrement discharging time is shortened. When young rats take the probiotics bifidobacterium bifidum CCFM1523, the allergic symptom is relieved to a certain degree, and particularly, the apparent score of food allergic rats induced by OVA and the content of OVA-sIgE and mMCP-1 in bodies are reduced. The bifidobacterium bifidum CCFM1523 has the effect of relieving intractable constipation in a purgative colonic animal model constructed by using the folium sennae, specifically, after intervention of the bifidobacterium bifidum CCFM1523, the number of excrement grains of mice within 5 hours and the water content of the excrement are remarkably increased, and meanwhile, the time for discharging first black excrement is shortened.

The invention discloses bifidobacterium breve for regulating intestinal motility and aquaporin and application of the bifidobacterium breve, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium breve CCFM1078 is screened out, and the bifidobacterium breve CCFM1078 has the effect of regulating intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP3, AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention belongs to the technical field of medical application, and particularly relates to a traditional Chinese medicine application for improving gastrointestinal discomfort and a preparation method thereof. The traditional Chinese medicine patch for improving gastrointestinal discomfort comprises the following raw materials in parts by weight: 20-25 parts of clove, 18-22 parts of codonopsis pilosula, 13-18 parts of semen raphani, 10-15 parts of linaria lingua, 5-10 parts of pinellia ternate, 9-13 parts of fingered citron, 6-11 parts of maple and 3-8 parts of liquorice. The traditional Chinese medicine prescription provided by the invention is safe, non-toxic and mild in medicine property, and can tonify without stagnation and warm without dryness. The traditional Chinese medicine patch disclosed by the invention can regulate the gastrointestinal hormone level and promote motilin secretion, so that the gastric emptying rate and the small intestine propulsion rate are improved, the gastrointestinal motility is enhanced, the digestive function is improved, and the traditional Chinese medicine patch shows good potential in the aspect of improving gastrointestinal discomfort.

The present application provides the application of torreya grandis inner seed coat extract in preparing a product for treating constipation, wherein the torreya grandis inner seed coat extract is obtained by stripping the black coat of torreya grandis after roasting, and then extracting the black coat with water or 50% ethanol, and drying the extract obtained by vacuum concentration; and the prepared torreya grandis inner seed coat extract is used in preparing various dosage forms of drugs for treating constipation and products for lubricating intestines and defecating. The prepared torreya grandis inner seed coat extract powder has the effect of promoting intestinal propulsion, can improve the small intestinal propulsion function, and can achieve good lubricating intestines and defecating effect, and can be used for treating constipation. The torreya grandis inner seed coat powder can be used for preparing food with the effect of lubricating intestines and defecating, so that the function of treating and conditioning constipation can be achieved through diet therapy, and the side effects of the commonly used drugs such as magnesium sulfate, castor oil, cisapride, loperamide, domperidone and bisacodyl can be overcome, and the resource utilization rate of torreya grandis is increased, and the economic benefits are increased.

This invention discloses a method for preparing wheat oligopeptides that improve gastrointestinal function and their applications, relating to the technical field of preparing oligopeptides through enzymatic hydrolysis and their applications. The invention comprises wheat oligopeptides, a 5-HT4 receptor agonist, dietary fiber, prebiotics, and probiotics in a specific ratio, which can be formulated into powders, granules, or tablets for oral administration. It enhances propulsive peristalsis and secretion by activating the 5-HT4 pathway, while the oligopeptides provide a nutrient substrate to promote mucosal protein synthesis and barrier repair. The fiber / prebiotic / probiotic combination regulates the gut microbiota and produces short-chain fatty acids, thereby synergistically improving gastric emptying and small intestinal propulsion, improving defecation, and reducing the risk of recurrence.

This invention provides a *Hydroxystoma coagulans* strain and its uses. This *Hydroxystoma coagulans* strain was deposited on November 3, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 36494. The *Hydroxystoma coagulans* strain provided by this invention has multiple functions: it can enhance whole intestinal motility, accelerating small intestinal propulsion and promoting colonic emptying; it can soften stool, significantly increasing stool water content, thus fundamentally improving constipation.