23 results about "Small intestinal motility" patented technology

The invention relates to the technical field of food nutrition and health care and biological medicines, in particular to application of beta-1, 3 / alpha-1, 3-glucan in preparation of medicines for treating and / or preventing obesity and / or body weight super-severe illness and digestion-aiding health food. According to the experimental results, high-glucose and high-fat rats are continuously fed in the stomach for 8 weeks, and the food intake can be effectively reduced and the body weight can be reduced through preventive administration; the conclusion that beta-1, 3 / alpha-1, 3-glucan has the digestion-aiding health-care food function can be obtained according to the requirements of'health-care food function inspection and evaluation method (2023 edition) by combining the research results that beta-1, 3 / alpha-1, 3-glucan has the stimulation effect on small intestine peristalsis, promotes the growth of intestinal beneficial bacteria and regulates intestinal health in the existing research. The invention provides a new direction for preparing the medicine for treating and / or preventing obesity and / or body weight super-severe illness and health-care food beneficial to digestion.

The invention discloses bifidobacterium longum subsp. Infantis for regulating intestinal motility and aquaporin and application of the bifidobacterium longum subsp. Infantis, and belongs to the technical field of microorganisms. According to the invention, the bifidobacterium longum subsp. Infantis CCFM1269 is screened, and the bifidobacterium longum subsp. Infantis CCFM1269 has the effects of intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention provides a traditional Chinese medicine composition for improving spleen and stomach health and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 30 parts of rhizoma dioscoreae, 15 to 20 parts of rhizoma atractylodis macrocephalae, 8 to 15 parts of fructus aurantii, 10 to 15 parts of red dates, 8 to 12 parts of liquorice root, 10 to 15 parts of inulin, 6 to 10 parts of fructus amomi and 5 to 8 parts of cassia twig. The lauric acid modified fenugreek gum (LA-FG) is used as an emulsifier and an immobilized enzyme carrier to construct a water-oil two-phase enzymolysis system, so that the content of effective active ingredients in the traditional Chinese medicine composition, the product stability and the bioavailability are remarkably improved. In addition, the traditional Chinese medicine composition can effectively improve the gastric emptying rate and the small intestine propulsion rate, the level of motilin and anti-inflammatory factors IL-10 is improved, and the effect of improving spleen and stomach health is achieved through multi-target-point synergism. The method successfully breaks through double limitations of a traditional process and an existing scheme, effectively considers volatile oil protection, efficient enzymatic conversion and system stability, and provides a new path for promoting technical upgrading of the traditional Chinese medicine industry.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for treating liver depression and spleen deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from codonopsis pilosula, rhizoma atractylodis macrocephalae stir-fried with bran, radix bupleuri, stir-fried radix paeoniae alba, pericarpium citri reticulatae, fructus aurantii stir-fried with bran, ginger processed pinellia, radix salviae miltiorrhizae, medicated leaven, stir-fried endothelium corneum gigeriae galli and fingered citron according to The traditional Chinese medicine composition is based on the theory of inhibiting wood and supporting soil in traditional Chinese medicine, and all the components have a synergistic effect and have the effects of soothing the liver, relieving depression, strengthening the spleen and harmonizing the stomach. Animal experiments prove that the traditional Chinese medicine composition provided by the invention can significantly improve the gastric emptying rate and the small intestine propulsion rate of a chronic gastritis model, and can down-regulate the gene expression of gastric mucosa intestinal metaplasia related markers CDX2 and MUC2.

The application provides application of Lactobacillus paracasei K56 in preparation of products for improving intestinal peristalsis and promoting defecation, and relates to the technical field of biotechnology. The application comprises application of Lactobacillus paracasei K56 in preparation of products containing at least one efficacy of improving small intestinal propulsion rate of a subject, promoting intestinal peristalsis of the subject and promoting defecation of the subject, wherein the products comprise a fermentation product fermented by using a fermenting agent containing Lactobacillus paracasei K56, and the fermentation substrate contains milk; and the application comprises increasing the proportion of the number of dead Lactobacillus paracasei K56 cells in the fermented product relative to the total number of Lactobacillus paracasei K56 cells. The application alleviates the technical problem that inactivation of bacteria in a fermented product causes the probiotic function to be affected.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a preparation method of a probiotic fermented traditional Chinese medicine preparation, which comprises the following steps: carrying out aerobic fermentation on part of traditional Chinese medicine raw materials to obtain aerobic fermentation liquor and aerobic fermentation residues; performing anaerobic fermentation on the other part of the traditional Chinese medicine raw materials to obtain anaerobic fermentation liquid and anaerobic fermentation residues; mixing the aerobic and anaerobic fermentation residues and carrying out solid-state fermentation to prepare functional mycoplasm; and mixing the aerobic and anaerobic fermentation broth with the functional mycoplasm to obtain the microbial inoculum. According to the preparation method, a segmented fermentation process is combined with a fermentation inducer compounded by tea polyphenol and yeast extract, so that the problems of poor taste and low utilization rate of active ingredients of a traditional Chinese medicine preparation are effectively solved. The probiotic fermented traditional Chinese medicine preparation prepared by the preparation method disclosed by the invention is mellow in taste, palatable in sourness and sweetness and high in utilization rate of active ingredients, has the effects of strengthening the spleen and stomach and promoting digestion and removing food stagnation, and can be used for remarkably improving the gastrointestinal function, effectively reducing gastric emptying hysteresis and improving the small intestine propulsion capability and the overall gastrointestinal digestion capability.

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

The invention provides a digestion-assisting fermented beverage and a preparation method thereof, and relates to the technical field of functional beverages, and the IPC classification number belongs to A23L2. The digestion-assisting fermented beverage disclosed by the invention is prepared from hawthorn, emblic leafflower fruit, bighead atractylodes rhizome, dried orange peel, poria cocos, malt and liquorice through enzymolysis and fermentation. Wherein the hawthorn is used as a monarch drug for eliminating meat accumulation, promoting the circulation of qi and relieving flatulence; the rhizoma atractylodis macrocephalae has the effects of tonifying spleen, eliminating dampness and enhancing small intestine peristalsis, and is a ministerial drug; the dried orange peel and the poria cocos are used for clearing damp and regulating intestinal flora, and the malt is used for eliminating grain accumulation and activating amylase; and liquorice harmonizes and protects stomach. All the medicines are combined to achieve the effects of promoting digestion, eliminating stagnation, tonifying spleen, eliminating dampness, promoting the circulation of qi and regulating the middle warmer. Test results show that the fermented beverage not only has good antioxidant activity, but also has an excellent effect of promoting gastrointestinal digestion.

The invention discloses an agaro-oligosaccharide oral solution with a constipation relieving function, and belongs to the technical field of food biology. The invention provides a preparation method of agarotriose. Main components which mainly exert anti-inflammatory activity are analyzed through clinical evaluation. According to the invention, agarotriose is extracted by adopting an enzymolysis method to treat LOP-induced constipation mice, and the influence of main components on model mice is investigated from the aspects of excrement water content, small intestine propulsion rate, first-grain black excrement discharge time, colon pathological structure and the like. Experimental results show that compared with an LOP group, the agarotriose high-dose group can significantly improve constipation symptoms, relieve inflammatory response and promote colonic mucosa repair, so that agarotriose can be used as a good functional food for relieving constipation.

The application provides a kind of Huayu Xiaoshi medicinal composition and its preparation method and application, the composition is made of Huangqi 8-12 parts, Danggui 1-3 parts, Juhong 18-22 parts, Doukou 10-20 parts, Gancao 8-12 parts, lemon 8-12 parts, Shanzha 1-3 parts, fine corn powder 46-50 parts, gradient drying, grading ultrafine grinding, constant temperature and humidity mixing process is used to prepare.The application constructs the collaborative system of tonifying qi-blood-activating blood and food digestion, promotes the small intestine propulsion rate of food accumulation and blood stasis model rats, is safe and non-toxic, can be made into various oral preparations, adopts gradient drying, grading ultrafine grinding, constant temperature and humidity three-dimensional mixing process, maximally retains Doukou volatile oil, lemon vitamin C and other heat-sensitive effective components, and is used for the treatment of food accumulation and blood stasis.

The invention discloses bifidobacterium bifidum capable of relieving postpartum constipation of a mother generation and food allergy of a child generation and application of the bifidobacterium bifidum, and belongs to the field of microorganisms. A strain of bifidobacterium bifidum CCFM1523 is screened out, postpartum constipation of female rats is relieved, specifically, the number and weight of black excrement grains in 5 h and the small intestine propulsion rate can be increased, and the first black excrement discharging time is shortened. When young rats take the probiotics bifidobacterium bifidum CCFM1523, the allergic symptom is relieved to a certain degree, and particularly, the apparent score of food allergic rats induced by OVA and the content of OVA-sIgE and mMCP-1 in bodies are reduced. The bifidobacterium bifidum CCFM1523 has the effect of relieving intractable constipation in a purgative colonic animal model constructed by using the folium sennae, specifically, after intervention of the bifidobacterium bifidum CCFM1523, the number of excrement grains of mice within 5 hours and the water content of the excrement are remarkably increased, and meanwhile, the time for discharging first black excrement is shortened.

The invention discloses bifidobacterium breve for regulating intestinal motility and aquaporin and application of the bifidobacterium breve, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium breve CCFM1078 is screened out, and the bifidobacterium breve CCFM1078 has the effect of regulating intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP3, AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention belongs to the technical field of medical application, and particularly relates to a traditional Chinese medicine application for improving gastrointestinal discomfort and a preparation method thereof. The traditional Chinese medicine patch for improving gastrointestinal discomfort comprises the following raw materials in parts by weight: 20-25 parts of clove, 18-22 parts of codonopsis pilosula, 13-18 parts of semen raphani, 10-15 parts of linaria lingua, 5-10 parts of pinellia ternate, 9-13 parts of fingered citron, 6-11 parts of maple and 3-8 parts of liquorice. The traditional Chinese medicine prescription provided by the invention is safe, non-toxic and mild in medicine property, and can tonify without stagnation and warm without dryness. The traditional Chinese medicine patch disclosed by the invention can regulate the gastrointestinal hormone level and promote motilin secretion, so that the gastric emptying rate and the small intestine propulsion rate are improved, the gastrointestinal motility is enhanced, the digestive function is improved, and the traditional Chinese medicine patch shows good potential in the aspect of improving gastrointestinal discomfort.

The present application provides the application of torreya grandis inner seed coat extract in preparing a product for treating constipation, wherein the torreya grandis inner seed coat extract is obtained by stripping the black coat of torreya grandis after roasting, and then extracting the black coat with water or 50% ethanol, and drying the extract obtained by vacuum concentration; and the prepared torreya grandis inner seed coat extract is used in preparing various dosage forms of drugs for treating constipation and products for lubricating intestines and defecating. The prepared torreya grandis inner seed coat extract powder has the effect of promoting intestinal propulsion, can improve the small intestinal propulsion function, and can achieve good lubricating intestines and defecating effect, and can be used for treating constipation. The torreya grandis inner seed coat powder can be used for preparing food with the effect of lubricating intestines and defecating, so that the function of treating and conditioning constipation can be achieved through diet therapy, and the side effects of the commonly used drugs such as magnesium sulfate, castor oil, cisapride, loperamide, domperidone and bisacodyl can be overcome, and the resource utilization rate of torreya grandis is increased, and the economic benefits are increased.

The invention relates to an application of a traditional Chinese medicine composition in preparation of medicines for intestinal obstruction, which is characterized in that the traditional Chinese medicine composition is prepared from angelica sinensis, achyranthes bidentata, cistanche, rhizoma alismatis, cimicifugae foetidae and fructus aurantii. The composition disclosed by the invention can be used for relieving inflammatory response in a rat with incomplete intestinal obstruction and has an intestinal barrier protection function; for postoperative intestinal obstruction mice, the reduction of the small intestine propulsion rate of the mice can be obviously reversed, and the expression level of inflammatory factors is reduced. The traditional Chinese medicine composition has a good treatment effect on intestinal obstruction.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a honeysuckle arthralgia clearing preparation in preparation of a medicine for preventing or treating functional dyspepsia. The honeysuckle arthralgia clearing preparation is prepared from 11 raw medicinal materials including honeysuckle, caulis sinomenii, oldenlandia diffusa, radix scrophulariae, radix paeoniae alba, radix rehmanniae recen, pseudobulbus cremastrae seu pleiones, herba pyrolae, angelica sinensis, liquorice and centipede. Pharmacodynamic experiments prove that the honeysuckle arthralgia clearing granules have the effects of remarkably improving the gastric emptying function and the small intestine propelling function of rats, regulating and controlling the oxidative stress level, improving the serum MTL and GAS levels and reducing the serum VIP content, can be used for preventing or treating functional dyspepsia, and can be used for preventing or treating chronic pharyngitis. Especially, the traditional Chinese medicine composition has a remarkable effect on functional dyspepsia caused by stomach cold, spleen deficiency or liver depression. Meanwhile, the honeysuckle arthralgia clearing preparation is high in safety and small in toxic and side effects, and the clinical medication selection of patients is enriched.

This invention discloses a method for preparing wheat oligopeptides that improve gastrointestinal function and their applications, relating to the technical field of preparing oligopeptides through enzymatic hydrolysis and their applications. The invention comprises wheat oligopeptides, a 5-HT4 receptor agonist, dietary fiber, prebiotics, and probiotics in a specific ratio, which can be formulated into powders, granules, or tablets for oral administration. It enhances propulsive peristalsis and secretion by activating the 5-HT4 pathway, while the oligopeptides provide a nutrient substrate to promote mucosal protein synthesis and barrier repair. The fiber / prebiotic / probiotic combination regulates the gut microbiota and produces short-chain fatty acids, thereby synergistically improving gastric emptying and small intestinal propulsion, improving defecation, and reducing the risk of recurrence.

The present invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite, as well as its preparation method and application, belonging to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens, 6-10 parts of Ginseng, 4-6 parts of Licorice and 1-3 parts of Coptis chinensis. The various traditional Chinese medicine raw materials in the traditional Chinese medicine composition cooperate with each other, have good therapeutic effects on the symptoms of poor appetite associated with chronic renal failure, can significantly improve the condition of poor appetite, promote the body's absorption and utilization of nutrients in food, and improve small intestinal motility. The traditional Chinese medicine composition provided by the present invention can improve the symptoms of spleen and stomach deficiency and coldness in patients with chronic renal failure and poor appetite, and has excellent clinical application prospects.

The invention discloses a preparation method of an extract capable of recovering colon histopathologic injury, which comprises the following steps: taking purple dendrobium, adding pure water, carrying out wet crushing, decocting after crushing, cooling, filtering, concentrating to obtain purple dendrobium primary pulp, sterilizing, adding a proper amount of xylitol and purified water, blending, canning, and carrying out secondary sterilization, thereby obtaining the extract capable of recovering colon histopathologic injury. The extract is obtained. The extract disclosed by the invention can be used for effectively recovering weight loss caused by constipation, shortening the time of first black excrement, increasing the defecation frequency and the water content of excrement, improving the propulsion rate of small intestines and recovering pathological injury of colon tissue.

This invention provides a *Hydroxystoma coagulans* strain and its uses. This *Hydroxystoma coagulans* strain was deposited on November 3, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 36494. The *Hydroxystoma coagulans* strain provided by this invention has multiple functions: it can enhance whole intestinal motility, accelerating small intestinal propulsion and promoting colonic emptying; it can soften stool, significantly increasing stool water content, thus fundamentally improving constipation.

The application discloses a traditional Chinese medicine health-care patch with the functions of regulating qi and inducing defecation and a preparation method thereof. The traditional Chinese medicine health-care patch adopts a traditional Chinese medicine paste which comprises the following components in parts by weight: 50-70 parts of radix codonopsis, 50-70 parts of cyperus rotundus, 20-40 parts of amomum villosum, 20-40 parts of syzygium aromaticum, 20-40 parts of cinnamomum cassia, 20-40 parts of angelica sinensis, 35-55 parts of perilla leaf, 20-40 parts of pachystachys johnstonii, 10-20 parts of radix rhei, 10-20 parts of cumin, 20-40 parts of honey-fried licorice, 50-70 parts of honey-roasted foxtail millet, 20-40 parts of saussurea lappa, 35-55 parts of long-jointed knotweed root, 10-20 parts of vinegar, 10-20 parts of yellow rice wine, 5-15 parts of lubricant and 400-500 parts of honey. The traditional Chinese medicine health-care patch can significantly increase the small intestine propulsion rate of constipated mice through a mouse test, and has a significant curative effect on functional constipation through a human efficacy test, with a total effective rate of 93.9%, and the improvement of abdominal distension and abdominal pain symptoms of constipated children is particularly obvious, so that the traditional Chinese medicine health-care patch has a very good effect of regulating qi and inducing defecation.

The invention provides an application of any cell morphology of Witzia ciliaris IOB502 in preparation of a microbial agent for reducing intestinal moisture reabsorption. The nutritional cell morphology and the spore morphology of the strain have good effects on increasing the water content of excrement of normal mice, shortening the total gastrointestinal transport time of the normal mice, improving the small intestine propulsion rate of the normal mice, increasing the expression of colon c-Kit and SCF of the normal mice and reducing the expression of colon AQP8 of the normal mice, and no obvious difference exists. In the process of preparing the microbial agent of the Witzia coagulans IOB502, spores and nutrient cells do not need to be separated, and the effect of the directly prepared microbial agent is equivalent to that of a microbial agent in a pure spore state.

A room temperature fermented dairy product containing inactivated Bifidobacterium longum BBMN68 and inulin, and its manufacturing method and use. The room temperature fermented dairy product can significantly improve pepsin activity, improve food digestibility, promote small intestinal motility, and alleviate the symptoms of functional dyspepsia.