Composition of isomaltooligosaccharide and calcium ion antagonist as well as application thereof

A calcium ion antagonist and isomalt oligosaccharide technology, which is applied in the field of the composition of isomalt oligosaccharide and calcium ion antagonist, can solve the problem of increased osmotic pressure, does not involve the direct interaction between IMO and intestinal mucosal cells, etc. problem, to achieve a good application prospect, to solve the effect of constipation side effects

Inactive Publication Date: 2019-08-23
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, IMO is mostly used as dietary fiber, which is not completely absorbed by the intestine, and the osmotic pressure in the intestine increases to explain the enhanced gastrointestinal motility after taking IMO, or that IMO can balance the intestinal flora to produce and regulate gastrointestinal Exercise, but doesn't convincingly explain the diarrhea and constipation IMO
From the above studies, it can be seen that no matter from the osmotic pressure or the balance of microbial flora, there is no direct interaction between IMO and intestinal mucosal cells. Therefore, if the role of dietary fiber on gastrointestinal mucosal cells can be clarified The target of action has theoretical and practical value for guiding the normative use of IMO

Method used

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  • Composition of isomaltooligosaccharide and calcium ion antagonist as well as application thereof
  • Composition of isomaltooligosaccharide and calcium ion antagonist as well as application thereof
  • Composition of isomaltooligosaccharide and calcium ion antagonist as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A composition of isomalto-oligosaccharide and calcium ion antagonist in this embodiment, the mass ratio of isomalto-oligosaccharide and calcium ion antagonist is 10:1-1:1;

[0029] The calcium ion antagonist is any one of nifedipine, amlodipine, and felodipine.

Embodiment 2

[0031] The difference between this example and Example 1 is that the mass ratio of isomaltooligosaccharide to calcium ion antagonist is 10:1.

[0032] The action mechanism of the composition of this embodiment is to activate the calcium ion channel on the mucosa of the small intestine, and promote the influx of calcium ions to generate excitatory effect on the small intestine.

Embodiment 3

[0034] Effects of IMO on small intestinal motility in normal mice

[0035] 3.1 Experimental materials

[0036] IMO (batch number: 2018101113425, Guangzhou Huijian Biotechnology Co., Ltd.)

[0037] 3.2 Experimental animals

[0038] Kunming mice, weighing 18-22g, male or female (Jinan Pengyue Experimental Animal Breeding Co., Ltd.), license number: SCXK (Lu) 20140007.

[0039] 3.3 Experimental method

[0040] The mice were adaptively fed for one week and randomly divided into 8 groups: ① blank group, ② IMO (10 mg / kg), ③ IMO (20 mg / kg), ④ IMO (50 mg / kg), ⑤ IMO (100 mg / kg), ⑥ IMO (200 mg / kg ), ⑦IMO (250mg / kg), ⑧IMO (300mg / kg), wherein mg / kg represents the dosage per kilogram of body weight of the animal, 10 in every group, half male and half male. Each mouse was intragastrically administered with a volume of 0.2ml, the blank group was administered with ink, and the other groups were administered with ink containing a corresponding amount of IMO. After 15 minutes, the mice wer...

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Abstract

The invention relates to a composition of isomaltooligosaccharide and a calcium ion antagonist. According to the composition, the isomaltooligosaccharide which is not absorbed by an intestinal tract can be used for relieving the constipation side effect generated by use of hypotensive medicines while the calcium ion antagonist reduces pressure. The invention belongs to the fields of the composition of the isomaltooligosaccharide and the calcium ion antagonist as well as application thereof. In the composition of the isomaltooligosaccharide and the calcium ion antagonist, the mass ratio of theisomaltooligosaccharide to the calcium ion antagonist is 10:1 to 1:1. The composition of the isomaltooligosaccharide and the calcium ion antagonist can solve the problem of the constipation side effect generated by long-time use of the calcium ion antagonist, can discloses the newest action mechanism of the action, can provide the optimal combined proportion of the isomaltooligosaccharide and thecalcium ion antagonist, and has good application prospect.

Description

technical field [0001] The invention relates to a composition of isomaltose oligosaccharide and calcium ion antagonist, which can alleviate the constipation caused by taking antihypertensive drugs while lowering blood pressure, and belongs to the composition of isomaltooligosaccharide and calcium ion antagonist and its technical fields of application. Background technique [0002] Calcium ion antagonists such as nifedipine, amlodipine, and felodipine are commonly used "dipine" antihypertensive drugs, which belong to one of the five categories of drugs recommended in the "Guidelines for the Prevention and Treatment of Hypertension in China" in 2018 . Calcium ion antagonists such as nifedipine can prevent calcium ions from entering the myocardium or vascular smooth muscle cells, causing a decrease in the tension of blood vessels around the body and coronary arteries, resulting in a decrease in blood pressure and an increase in coronary blood flow. Some patients may experienc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/702A61K31/7016A61K31/4422A61P1/10
CPCA61K31/4422A61K31/7016A61K31/702A61K45/06A61P1/10A61K2300/00
Inventor 柳全文王晓洁吕晓文肖波
Owner LUDONG UNIVERSITY
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