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Fructooligosaccharide and calcium ion antagonist composition and application thereof

A technology of calcium ion antagonists and fructooligosaccharides, which is applied in the field of compositions of fructooligosaccharides and calcium ion antagonists, can solve problems that do not involve direct interaction between FOS and intestinal mucosal cells, osmotic pressure increase, etc., and achieve a solution Constipation side effect, good application prospect effect

Inactive Publication Date: 2019-09-10
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, FOS is mostly used as dietary fiber, which is not completely absorbed by the intestine, and the osmotic pressure in the intestine is increased to explain the enhanced gastrointestinal motility after taking FOS, or that FOS can balance the intestinal flora to produce and regulate gastrointestinal Exercise, but does not convincingly explain diarrhea and constipation after taking FOS
From the above studies, it can be seen that no matter from the osmotic pressure or the balance of microbial flora, there is no direct interaction between FOS and intestinal mucosal cells. Therefore, if the role of dietary fiber on gastrointestinal mucosal cells can be clarified The target of action has theoretical and practical value for guiding the standardized use of FOS

Method used

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  • Fructooligosaccharide and calcium ion antagonist composition and application thereof
  • Fructooligosaccharide and calcium ion antagonist composition and application thereof
  • Fructooligosaccharide and calcium ion antagonist composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composition of fructooligosaccharide and calcium ion antagonist of this embodiment, the mass ratio of fructooligosaccharide and calcium ion antagonist is 20:1 to 5:1;

[0029] The calcium ion antagonist is any one of nifedipine, amlodipine, and felodipine.

Embodiment 2

[0031] The difference between this embodiment and embodiment 1 is that the mass ratio of fructooligosaccharide and calcium ion antagonist is 10:1.

[0032] The mechanism of action of the composition of this embodiment is to activate calcium ion channels on the mucosa of the small intestine and promote the influx of calcium ions to produce small intestine excitatory effects.

Embodiment 3

[0034] The effect of FOS on the motility of the small intestine of normal mice

[0035] 3.1 Experimental materials

[0036] FOS (batch number: 2018100362203, Guangzhou Huijian Biological Technology Co., Ltd.)

[0037] 3.2 Experimental animals

[0038] Kunming mice, weighing 18-22g, male or female (Jinan Pengyue Experimental Animal Breeding Co., Ltd.), license number: SCXK (鲁)20140007.

[0039] 3.3 Experimental method

[0040] Mice were adaptively raised for one week and randomly divided into 8 groups: ① blank group, ② FOS (10 mg / kg), ③ FOS (20 mg / kg), ④ FOS (50 mg / kg), ⑤ FOS (100 mg / kg), ⑥ FOS (200 mg / kg) ), ⑦FOS (250mg / kg), ⑧FOS (300mg / kg), where mg / kg represents the dosage per kilogram of the animal's body weight. There are 10 animals in each group, half male and female. Each mouse was given an intragastric administration volume of 0.2ml, the blank group was given an ink gavage, and the other groups were given an ink containing a corresponding amount of FOS. After 15 minutes, the mi...

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Abstract

The invention relates to a fructooligosaccharide and calcium ion antagonist composition, and belongs to the technical field of fructooligosaccharide and calcium ion antagonist compositions and application thereof. The composition can relieve the constipation side effect caused by taking an antihypertensive drug by using fructooligosaccharide which is not absorbed by the intestine while the calciumion antagonist reduces blood pressure. In the fructooligosaccharide and calcium ion antagonist composition, the mass ratio of the fructooligosaccharide to the calcium ion antagonist is 20:1-5:1. Thefructooligosaccharide and calcium ion antagonist composition can relieve the constipation side effect caused by taking the calcium ion antagonist for a long time, the latest action mechanism of the effect is revealed, the optimal mixing ratio of the fructooligosaccharide to the calcium ion antagonist is provided, and the fructooligosaccharide and calcium ion antagonist composition has good application prospects.

Description

Technical field [0001] The present invention relates to a composition of fructooligosaccharide and calcium ion antagonist, which can relieve constipation caused by taking antihypertensive drugs while lowering blood pressure, and belongs to the composition of fructooligosaccharide and calcium ion antagonist and the composition thereof Application technology field. Background technique [0002] Calcium antagonists, such as nifedipine, amlodipine, and felodipine, are commonly used "dipine" antihypertensive drugs and belong to one of the five recommended drugs in the "Guidelines for Prevention and Treatment of Hypertension in China in 2018" . Calcium antagonists such as nifedipine can prevent calcium ions from entering the myocardium or vascular smooth muscle cells, causing a decrease in the tone of blood vessels in the body and coronary vessels, resulting in a decrease in blood pressure and an increase in coronary blood flow. Some patients will experience constipation when taking ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/702A61K31/4422A61P9/12A61P1/10
CPCA61K31/4422A61K31/702A61K45/06A61P1/10A61P9/12A61K2300/00
Inventor 柳全文王晓洁吕晓文肖波
Owner LUDONG UNIVERSITY
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