Composition containing biguanide antidiabetic medicament and ACEI (Angiotensin-Converting Enzyme Inhibitors) medicament and applications thereof

A biguanide hypoglycemic and composition technology, applied in the field of preparation of drugs for the prevention or treatment of diabetes combined with hypertension, can solve the problems of no prevention or treatment of diabetes combined with hypertension, etc.

Inactive Publication Date: 2010-10-27
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the existing patents and scientific literature, we have not found any reports on the combination of biguanide hypoglycemic drugs a

Method used

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  • Composition containing biguanide antidiabetic medicament and ACEI (Angiotensin-Converting Enzyme Inhibitors) medicament and applications thereof
  • Composition containing biguanide antidiabetic medicament and ACEI (Angiotensin-Converting Enzyme Inhibitors) medicament and applications thereof
  • Composition containing biguanide antidiabetic medicament and ACEI (Angiotensin-Converting Enzyme Inhibitors) medicament and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～8

[0070] Embodiments 1 to 8: Preparation of compound benazepril biguanide tablets with different content ratios (1000 tablets)

[0071] Table 1 embodiment 1~8 tablet prescription composition

[0072]

[0073] Preparation Process:

[0074] (1) According to Table 1, take the benazepril and biguanide hypoglycemic drugs of the prescription amount, and mix them uniformly by the method of equal increment after passing through a 100-mesh sieve;

[0075] (2) Other auxiliary materials are used after passing through a 100-mesh sieve respectively;

[0076] (3) Take pregelatinized starch, microcrystalline cellulose, carboxymethyl starch sodium and mix evenly with the raw material drug that mixes again by weighing the recipe quantity and mix evenly;

[0077] (4) Add appropriate amount of binder to make soft material, granulate with 24 mesh sieve, granulate with 20 mesh sieve, and dry at 40-45°C;

[0078] (5) Add an appropriate amount of magnesium stearate to the dry granules, mix them ...

Embodiment 9～30

[0079] Embodiments 9-30: Preparation of Compound Metformin Prily Tablets (1000 Tablets Quantity)

[0080] Table 2 embodiment 9~30 tablet prescription composition

[0081]

[0082] Continuation of Table 2 Embodiment 9~30 Tablet Prescription Composition

[0083]

[0084] Preparation Process:

[0085] (1) According to Table 2, take metformin hydrochloride and pril class antihypertensive drugs of the prescribed amount according to Table 2, pass through a 100-mesh sieve and mix uniformly by the method of equal increments for subsequent use;

[0086] (2) Other auxiliary materials are used after passing through a 100-mesh sieve respectively;

[0087] (3) Take pregelatinized starch, microcrystalline cellulose, carboxymethyl starch sodium and mix evenly with the raw material drug that mixes again by weighing the recipe quantity and mix evenly;

[0088] (4) Add appropriate amount of binder to make soft material, granulate with 24 mesh sieve, granulate with 20 mesh sieve, and dr...

Embodiment 31-42

[0090] Example 31-42: Preparation of Compound Phenformin Capsules (1000 Tablets)

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PUM

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Abstract

The invention relates to a medicament composition containing biguanide antidiabetic medicament, ACEI (Angiotensin-Converting Enzyme Inhibitors) medicament and a pharmaceutically acceptable carrier. The invention also relates to the applications of the medicament composition in the preparation of medicaments for preventing or treating diabetes mellitus with hypertension. The implementation of the invention provides the medicament composition with specific applications, and the medicament composition not only has a precise curative effect, but also can improve the compliance of patients. The patients can take the medicament conveniently, and the medical expense is reduced. The invention has a better market prospect, and belongs to the field of pharmacy.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing a biguanide hypoglycemic drug and a pril antihypertensive drug, and the use of the pharmaceutical composition in preparing a drug for preventing or treating diabetes combined with hypertension. The present invention belongs to the field of pharmacy. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by elevated blood sugar caused by defects in insulin secretion and (or) action. Diabetic patients with long-term poor blood sugar control may be accompanied by various organs, especially eye, heart, blood vessel, kidney, nerve damage or organ insufficiency or failure, resulting in disability or premature death. In recent years, with the development of social economy and the improvement of residents' living standards in various countries in the world, the incidence and prevalence of diabetes have increased year by year, becoming a major social problem that thr...

Claims

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Application Information

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IPC IPC(8): A61K31/675A61K31/55A61K31/40A61K31/404A61K31/403A61K31/401A61K31/4015A61K31/472A61K31/155A61P9/10A61P3/10
Inventor 邵德龙王文艳田敏卿陈光亮徐希平
Owner 北京奥萨医药研究中心有限公司
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